PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1832154-7 1991 Furthermore, phorbol ester and forskolin treatment of cells before CD3 stimulation reduces the level of tyrosine phosphorylation of PLC gamma 1 and the PLC activity associated with APTyr Ab. Phorbol Esters 13-26 phospholipase C gamma 1 Homo sapiens 132-143 11094067-9 2000 These studies demonstrate that the PLC-gamma1 SH2(N) and SH2(C) domains play functionally distinct roles during TCR-mediated signaling and identify a non-Ca(2+)-related signaling function linked to the SH2(C) domain, which couples TCR plus phorbol ester-CD28 costimulation to the activation of the IL-2 promoter in T lymphocytes. Phorbol Esters 240-253 phospholipase C gamma 1 Homo sapiens 35-45 1370476-0 1992 Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1. Phorbol Esters 44-57 phospholipase C gamma 1 Homo sapiens 155-166