PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9891065-3 1999 The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Phorbol Esters 157-170 FBJ osteosarcoma oncogene Mus musculus 40-45 9891065-3 1999 The serum response element (SRE) in the c-fos promoter is necessary and sufficient for induction of transcription of c-fos by serum, growth factors, and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Phorbol Esters 157-170 FBJ osteosarcoma oncogene Mus musculus 117-122 9694514-12 1998 These included the recognition sequence for the nuclear transcription factor SP1 and the phorbol ester response sequence which binds the Fos/Jun heteromeric transcription factor AP1. Phorbol Esters 89-102 FBJ osteosarcoma oncogene Mus musculus 137-140 9315102-0 1997 Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters. Phorbol Esters 145-159 FBJ osteosarcoma oncogene Mus musculus 23-28 8548747-7 1996 c-fos mRNA expression induced by EGF, fibroblast growth factor, or phorbol ester was also insensitive to inhibition by CGP 57148. Phorbol Esters 67-80 FBJ osteosarcoma oncogene Mus musculus 0-5 8564068-8 1995 The phorbol ester induced a time-dependent accumulation of c-fos mRNA and protein was measured by solution hybridization and immunocytochemistry, respectively. Phorbol Esters 4-17 FBJ osteosarcoma oncogene Mus musculus 59-64 8562703-3 1995 We confirmed that c-fos behaves as an immediate-early response gene in spermatogenic cells after stimulation of protein kinase C with phorbol ester or after intercellular calcium levels are raised with calcium ionophore. Phorbol Esters 134-147 FBJ osteosarcoma oncogene Mus musculus 18-23 7806548-6 1994 The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) could in itself induce c-fos expression, but pretreatment with TPA did not abolish the ability of norepinephrine to induce c-fos expression, indicating that TPA-sensitive protein kinase C was not a primary mediator in this pathway. Phorbol Esters 4-17 FBJ osteosarcoma oncogene Mus musculus 84-89 7553596-0 1995 A labile hyperphosphorylated c-Fos protein is induced in mouse fibroblast cells treated with a combination of phorbol ester and anti-tumor promoter curcumin. Phorbol Esters 110-123 FBJ osteosarcoma oncogene Mus musculus 29-34 7806548-6 1994 The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) could in itself induce c-fos expression, but pretreatment with TPA did not abolish the ability of norepinephrine to induce c-fos expression, indicating that TPA-sensitive protein kinase C was not a primary mediator in this pathway. Phorbol Esters 4-17 FBJ osteosarcoma oncogene Mus musculus 184-189 8034726-12 1994 Finally, the Thr642 mutant PKC beta 1 lacks enzymatic activity and, when expressed in NIH 3T3 cells, reduces phorbol ester-induced c-fos promoter activity. Phorbol Esters 109-122 FBJ osteosarcoma oncogene Mus musculus 131-136 8198544-2 1994 This gene construct contains the entire upstream regulatory sequence of c-fos, and expression of the endogenous and fusion gene was shown by Northern analysis to correlate upon induction with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA). Phorbol Esters 196-209 FBJ osteosarcoma oncogene Mus musculus 72-77 8397429-11 1993 Phorbol ester (TPA) and calcium ionophore A23187 also caused a rapid but transient c-fos expression. Phorbol Esters 0-13 FBJ osteosarcoma oncogene Mus musculus 83-88 8118885-13 1994 We observed that phorbol ester stimulation of PR30-3 induces the expression of the early response gene c-fos, previously shown to be PKC dependent in this cell line. Phorbol Esters 17-30 FBJ osteosarcoma oncogene Mus musculus 103-108 1394140-5 1992 Both drugs blocked the phorbol ester-induced expression of the c-fos proto-oncogene. Phorbol Esters 23-36 FBJ osteosarcoma oncogene Mus musculus 63-68 8319766-9 1993 The c-jun gene is expressed constitutively and both IL2 and phorbol esters induce the expression of c-fos to generate a functional AP1 capable of repressing cell death. Phorbol Esters 60-74 FBJ osteosarcoma oncogene Mus musculus 100-105 1594242-4 1992 This overexpression of c-fos was not modified in response to protein kinase C agonists such as phorbol esters, but increased in response to the adenylate cyclase activator forskolin. Phorbol Esters 95-109 FBJ osteosarcoma oncogene Mus musculus 23-28 1417179-8 1992 The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours. Phorbol Esters 20-33 FBJ osteosarcoma oncogene Mus musculus 99-102 1417179-8 1992 The tumor-promoting phorbol ester (phorbol 12-myristate 13-acetate [PMA]), known to induce jun and fos gene expression, caused increases in jun-B and fos-B that preceded the decrease in albumin mRNA levels at 24 hours. Phorbol Esters 20-33 FBJ osteosarcoma oncogene Mus musculus 150-153 1617671-1 1992 We have compared the mechanisms of the transcriptional induction of c-fos in mouse epidermal cells JB6 (clone 30) by an extracellular burst of active oxygen of the type produced by inflammatory phagocytes to induction by serum and phorbol ester. Phorbol Esters 231-244 FBJ osteosarcoma oncogene Mus musculus 68-73 1713662-0 1991 Defective induction of Jun and Fos-related proteins in phorbol ester-resistant EL4 mouse thymoma cells. Phorbol Esters 55-68 FBJ osteosarcoma oncogene Mus musculus 31-34 1554749-1 1992 Phorbol esters, epidermal growth factor (EGF) and serum induce the transient expression of the c-jun and c-fos proto-oncogenes in quiescent fibroblasts. Phorbol Esters 0-14 FBJ osteosarcoma oncogene Mus musculus 105-110 1379817-4 1992 Exposure of quiescent Mel-ab cells to the PKC-activating phorbol esters TPA or sapintoxin A at 81 nM for 2 h increased levels of mRNA for six of seven TIS genes examined (twofold to 80-fold increase in steady-state RNA levels for TIS 1, 7, 8, 11, 21, and 28 (c-fos); TIS 10 expression was not affected). Phorbol Esters 57-71 FBJ osteosarcoma oncogene Mus musculus 259-264 1718584-0 1991 Inhibition of cell proliferation, protein kinase C, and phorbol ester-induced fos expression by the dihydropyridine derivative B859-35. Phorbol Esters 56-69 FBJ osteosarcoma oncogene Mus musculus 78-81 1545825-4 1992 In this paper, we report that overexpression of GAP blocks the phorbol ester (tetradecanoyl phorbol acetate [TPA])-induced activation of p42 mitogen-activated protein kinase (p42mapk), c-fos expression, and DNA synthesis. Phorbol Esters 63-76 FBJ osteosarcoma oncogene Mus musculus 185-190 1832543-1 1991 The c-fos proto-oncogene is inducible by cAMP, phorbol esters, serum, and growth factors. Phorbol Esters 47-61 FBJ osteosarcoma oncogene Mus musculus 4-9 1906604-5 1991 Both in NIH 3T3 cells and in F9 cells a mutated c-fos promoter that binds SRF but fails to form a ternary complex, was inducible by serum and phorbol esters to the same extent as the wild-type promoter. Phorbol Esters 142-156 FBJ osteosarcoma oncogene Mus musculus 48-53 1713662-4 1991 Phorbol ester induced c-fos, jun-B, and jun-D RNAs within 20 min in both cell lines. Phorbol Esters 0-13 FBJ osteosarcoma oncogene Mus musculus 22-27 1713662-9 1991 These results suggest that defective induction of c-Jun and/or Fos-related proteins may contribute to the absence of phorbol ester-induced lymphokine production in resistant EL4 cells. Phorbol Esters 117-130 FBJ osteosarcoma oncogene Mus musculus 63-66 2538793-2 1989 In order to induce both phagocytosis and a rise in c-fos mRNA, binding to receptors must be followed by mobilization of Ca++ from intracellular Induction of c-fos transcription in macrophages by other agents acting through different intracellular "messengers", i.e. phorbol esters (protein kinase C), cholera toxin (cAMP) and dexamethasone (glucocorticoid receptor) also depends on intracellular Ca++. Phorbol Esters 266-280 FBJ osteosarcoma oncogene Mus musculus 51-56 2119054-3 1990 This sequence, denoted a "composite" glucocorticoid response element (GRE), was bound selectively in vitro both by the glucocorticoid receptor and by c-Jun and c-Fos, components of the phorbol ester-activated AP-1 transcription factor. Phorbol Esters 185-198 FBJ osteosarcoma oncogene Mus musculus 160-165 2167455-2 1990 This gene and the related cellular genes c-jun, jun B and jun D, encode transactivating (or repressing) DNA-binding proteins that form homo- or heterodimeric (Jun-Jun and Jun-Fos) complexes which recognize the AP-1 consensus sequence TGACTCA, a response element that confers sensitivity to the tumour-promoting phorbol ester TPA. Phorbol Esters 311-324 FBJ osteosarcoma oncogene Mus musculus 175-178 2138707-1 1990 Proto-oncogene products c-Fos and c-Jun form a complex which binds with high affinity to the 12-O-tetradecanoylphorbol-13-acetate (TPA) response DNA element and which stimulates transcription of phorbol ester- inducible genes. Phorbol Esters 195-208 FBJ osteosarcoma oncogene Mus musculus 24-29 2138707-9 1990 These results suggest that changes in the expression of mXBP/CRE-BP2, c-Fos, and c-Jun, which alter the ratio of mXBP-c-Jun to c-Fos-c-Jun complexes, would affect the relative expression of cyclic AMP and phorbol ester-responsive genes. Phorbol Esters 205-218 FBJ osteosarcoma oncogene Mus musculus 70-75 2138707-9 1990 These results suggest that changes in the expression of mXBP/CRE-BP2, c-Fos, and c-Jun, which alter the ratio of mXBP-c-Jun to c-Fos-c-Jun complexes, would affect the relative expression of cyclic AMP and phorbol ester-responsive genes. Phorbol Esters 205-218 FBJ osteosarcoma oncogene Mus musculus 127-132 1645446-9 1991 Activation of protein kinase C by phorbol esters did induce c-fos, c-myc, and JE in IRB cells, indicating that signalling pathways distal to this enzyme remained intact. Phorbol Esters 34-48 FBJ osteosarcoma oncogene Mus musculus 60-65 2123448-7 1990 Chronic preincubation with the phorbol ester phorbol 12-myristate 13-acetate interfered with the induction of c-fos by GH, suggesting that diacylglycerol and protein kinase C are involved in this effect of GH. Phorbol Esters 31-44 FBJ osteosarcoma oncogene Mus musculus 110-115 2538793-2 1989 In order to induce both phagocytosis and a rise in c-fos mRNA, binding to receptors must be followed by mobilization of Ca++ from intracellular Induction of c-fos transcription in macrophages by other agents acting through different intracellular "messengers", i.e. phorbol esters (protein kinase C), cholera toxin (cAMP) and dexamethasone (glucocorticoid receptor) also depends on intracellular Ca++. Phorbol Esters 266-280 FBJ osteosarcoma oncogene Mus musculus 157-162 3365842-1 1988 Hyperplasiogenic and tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate or 12-O-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo. Phorbol Esters 37-51 FBJ osteosarcoma oncogene Mus musculus 198-203 3365842-0 1988 Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo. Phorbol Esters 24-38 FBJ osteosarcoma oncogene Mus musculus 42-47 3108267-6 1987 Down-regulation of protein kinase C by long-term exposure to phorbol esters prevented c-fos and c-myc induction by bombesin. Phorbol Esters 61-75 FBJ osteosarcoma oncogene Mus musculus 86-91 2840568-5 1988 In cells made protein-kinase C deficient, c-fos induction by phorbol ester was abolished; by contrast, c-fos was still induced by cAMP-elevating agents in protein kinase C-depleted cells. Phorbol Esters 61-74 FBJ osteosarcoma oncogene Mus musculus 42-47 2430281-1 1986 Phorbol esters activate protein kinase C and induce expression of the c-fos and c-myc protooncogenes in density-arrested BALB/c 3T3 (A31) cells; in contrast, epidermal growth factor (EGF) does not activate protein kinase C and is a poor inducer of c-fos and c-myc in these confluent cells. Phorbol Esters 0-14 FBJ osteosarcoma oncogene Mus musculus 70-75 2430281-1 1986 Phorbol esters activate protein kinase C and induce expression of the c-fos and c-myc protooncogenes in density-arrested BALB/c 3T3 (A31) cells; in contrast, epidermal growth factor (EGF) does not activate protein kinase C and is a poor inducer of c-fos and c-myc in these confluent cells. Phorbol Esters 0-14 FBJ osteosarcoma oncogene Mus musculus 248-253 2430281-2 1986 We show that, when A31 cells were subconfluent and made quiescent by serum deprivation, the phorbol ester phorbol 12-myristate 13-acetate induced c-fos and c-myc mRNA poorly, whereas EGF was a better inducer. Phorbol Esters 92-105 FBJ osteosarcoma oncogene Mus musculus 146-151 3087969-3 1986 We show that the plant lectin concanavalin A (ConA), the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA) and the Ca2+-ionophore A23187 each causes a rapid increase in both c-fos and c-myc mRNAs. Phorbol Esters 57-70 FBJ osteosarcoma oncogene Mus musculus 182-187 18719353-0 2008 Induction of the nuclear proto-oncogene c-fos by the phorbol ester TPA and v-H-Ras. Phorbol Esters 53-66 FBJ osteosarcoma oncogene Mus musculus 25-45