PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2494657-6 1989 These findings suggest the existence of a phorbol ester-sensitive factor, inducible in MOLT-4 and constitutively expressed or modified in YHHH, which operates in the pathway of induction of class I HLA by IFN-alpha but not in the pathway used by IFN-gamma. Phorbol Esters 42-55 interferon gamma Homo sapiens 246-255 2542091-2 1989 Significant enhancement of IFN gamma production by poly(I):poly(C) is observed in the presence of the phorbol ester, 12-O-tetradecanoylphorbol 13-acetate (TPA, a protein kinase C (PKC) activator). Phorbol Esters 102-115 interferon gamma Homo sapiens 27-36 2501656-5 1989 In addition, phorbol ester-induced differentiation of promyelocytic HL-60 cells and promonocytic THP-1 cells rendered the gamma.1 gene inducible by IFN-gamma. Phorbol Esters 13-26 interferon gamma Homo sapiens 148-157 3115598-4 1987 However, activation by the phorbol ester PMA in conjunction with either PHA or the calcium ionophore A23187 induces large amounts of IFN-gamma and IL-2. Phorbol Esters 27-40 interferon gamma Homo sapiens 133-142 3052858-1 1988 Previous studies in this laboratory have demonstrated that the adhesion of T lymphocytes to endothelial cell (EC) monolayers in vitro can be increased by preincubation of the EC with interferon-gamma, interleukin 1 (IL-1), tumor necrosis factor-alpha (TNF), or lipopolysaccharide (LPS), or by stimulation of the T cells with phorbol esters. Phorbol Esters 325-339 interferon gamma Homo sapiens 183-199 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. Phorbol Esters 26-40 interferon gamma Homo sapiens 177-186 2452208-2 1988 The activation of PBML by phorbol esters (5 to 100 ng/ml) for brief periods of time (5 min to 1 h) at 37 degrees C led to an increase in the relative percentage of adherence to IFN-gamma-treated keratinocytes from 15% for non-activated PBML to 30% for phorbol ester-treated PBML. Phorbol Esters 26-39 interferon gamma Homo sapiens 177-186 2452208-5 1988 Both reduction in temperature to 4 degrees C and preincubation of the phorbol ester-treated PBML with anti-LFA-1 monoclonal antibody, led to complete inhibition of this adherence reaction indicating a role for the LFA-1 molecule in phorbol ester-activated PBML/IFN-gamma-treated keratinocyte reactions. Phorbol Esters 70-83 interferon gamma Homo sapiens 261-270 2452208-7 1988 These results suggest that phorbol ester-activated PBML binds twice greater than resting PBML to IFN-gamma-treated keratinocytes, and this increased adherence may further contribute to homing of activated lymphocytes to the epidermis and mononuclear cell trafficking in the skin of inflammatory dermatoses. Phorbol Esters 27-40 interferon gamma Homo sapiens 97-106 6094340-2 1984 The amount of IFN gamma produced was enhanced in the presence of mezerein, a phorbol ester derivative. Phorbol Esters 77-90 interferon gamma Homo sapiens 14-23 3011901-4 1986 We now report that, on stable transfection of the genomic human IFN-gamma 8.6 Kb BamH DNA fragment into a mouse T lymphoblast cell line, both mRNA expression and synthesis of human IFN-gamma were stimulated by both the physiologic ligand IL 2 and phorbol ester. Phorbol Esters 247-260 interferon gamma Homo sapiens 64-73 3011901-4 1986 We now report that, on stable transfection of the genomic human IFN-gamma 8.6 Kb BamH DNA fragment into a mouse T lymphoblast cell line, both mRNA expression and synthesis of human IFN-gamma were stimulated by both the physiologic ligand IL 2 and phorbol ester. Phorbol Esters 247-260 interferon gamma Homo sapiens 181-190 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Phorbol Esters 83-97 interferon gamma Homo sapiens 17-26 3113436-0 1987 The induction of IFN-gamma production and m-RNAs of interleukin 2 and IFN-gamma by phorbol esters and a calcium ionophore. Phorbol Esters 83-97 interferon gamma Homo sapiens 70-79 3093810-0 1986 Induction of human interferon gamma with phorbol esters and phytohemagglutinin. Phorbol Esters 41-55 interferon gamma Homo sapiens 19-35 6165014-1 1981 Human gamma (immune) interferon (IFN-gamma) was produced in lymphocyte cultures stimulated with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate) and purified phytohemagglutinin. Phorbol Esters 98-111 interferon gamma Homo sapiens 33-42 6432902-3 1984 Although gamma-interferon (IFN gamma) is produced by T cells treated with phorbol esters, IFN gamma is probably not the mediator of enhancement of natural killer cell activity, because anti-IFN gamma antibodies failed to block this enhancement. Phorbol Esters 74-88 interferon gamma Homo sapiens 27-36 6409425-1 1983 Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). Phorbol Esters 49-62 interferon gamma Homo sapiens 217-226 6417283-5 1983 In addition to TPA and MZN, four other related phorbol esters caused a stimulation of IFN-gamma and IL-2, with the production of IL-2 paralleling the production of IFN-gamma. Phorbol Esters 47-61 interferon gamma Homo sapiens 86-95 6417283-5 1983 In addition to TPA and MZN, four other related phorbol esters caused a stimulation of IFN-gamma and IL-2, with the production of IL-2 paralleling the production of IFN-gamma. Phorbol Esters 47-61 interferon gamma Homo sapiens 164-173 6167986-1 1981 gamma (immune) interferon (IFN-gamma) was induced in cultures of fresh human lymphocytes by combined treatment with a phorbol ester (12-O-tetradecanoylphorbol 13-acetate, TPA) and the T cell mitogen phytohemagglutinin (PHA). Phorbol Esters 118-131 interferon gamma Homo sapiens 27-36 20045653-6 2010 Following stimulation with phorbol ester and ionomycin, PBMCs taken from MS patients in relapse developed a more inflammatory profile than those taken from controls or non-relapse patients, with greater expression of CD154, IL-17 and dual expression of IL-17/IFN-gamma. Phorbol Esters 27-40 interferon gamma Homo sapiens 259-268 18372499-7 2008 Greater frequencies of CD56(bright) NK cells from chronic HCV patients produced interferon-gamma compared with HCV responders (p = 0.05) and controls (p = 0.0001) after phorbol ester stimulation in vitro. Phorbol Esters 169-182 interferon gamma Homo sapiens 80-96 11236937-2 2001 We have previously shown that IFN-gamma restores phorbol ester-induced differentiation and cell cycle arrest in v-myc transformed human U-937 monoblasts. Phorbol Esters 49-62 interferon gamma Homo sapiens 30-39 11668484-0 2001 Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. Phorbol Esters 51-64 interferon gamma Homo sapiens 0-16 16186161-1 2005 Using intracellular cytokine staining we show herein that T cells will respond to short-term (6 h) activation with phorbol ester plus ionomycin by production of tumor necrosis factor (TNF), IFN-gamma or both. Phorbol Esters 115-128 interferon gamma Homo sapiens 190-199 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Phorbol Esters 199-212 interferon gamma Homo sapiens 111-127 12729920-1 2003 In this report, we demonstrate that NADPH oxidase is activated by tumor necrosis factor-alpha (TNF-alpha) plus interferon-gamma (IFN-gamma) in human monocytic cells (THP-1 cells) differentiated with phorbol ester (PMA) and that physiological concentration of 17beta-estradiol inhibits NADPH oxidase activity in THP-1 cells stimulated with TNF-alpha plus IFN-gamma. Phorbol Esters 199-212 interferon gamma Homo sapiens 129-138 12475762-7 2003 The combined application of the Ca(2+) ionophore ionomycin (1 microg/ml) and the phorbol ester phorbol 12-myristate 13-acetate (PMA; 5 microg/ml) stimulated IFN-gamma production, an effect again reversed by hyperosmolarity. Phorbol Esters 81-94 interferon gamma Homo sapiens 157-166 11302872-3 2001 After stimulation with phorbol ester/ionomycin, expression of the intracellular cytokines IFNgamma, IL2, IL4, and IL10 was determined in CD3+, CD3+CD8+ and CD3+CD8- T cells by flow cytometry. Phorbol Esters 23-36 interferon gamma Homo sapiens 90-98 10843764-8 2000 The synergy between HGF inducers and IFN-gamma is not common to all HGF inducers, because HGF production stimulated by epidermal growth factor and protein-kinase-C-activating phorbol esters was significantly inhibited by IFN-gamma. Phorbol Esters 175-189 interferon gamma Homo sapiens 221-230 10843764-8 2000 The synergy between HGF inducers and IFN-gamma is not common to all HGF inducers, because HGF production stimulated by epidermal growth factor and protein-kinase-C-activating phorbol esters was significantly inhibited by IFN-gamma. Phorbol Esters 175-189 interferon gamma Homo sapiens 37-46 10388538-4 1999 Stimulation of B cells with the phorbol ester PMA, however, induced strong HA recognition, which was inhibited by IFN-gamma and to some extent by IL-4. Phorbol Esters 32-45 interferon gamma Homo sapiens 114-123 10789681-4 2000 The combination of ionomycin and phorbol ester was able to mimic TCR stimulation to induce IFN-gamma production, although the same treatment triggered granule exocytosis inefficiently. Phorbol Esters 33-46 interferon gamma Homo sapiens 91-100 10608863-2 1999 When phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) are topically applied, prominent epidermal thickening occurs, and exposure to interferon (IFN)-gamma promotes increased epidermal thickness producing psoriatic lesions. Phorbol Esters 5-19 interferon gamma Homo sapiens 149-171 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 216-229 interferon gamma Homo sapiens 118-127 10201972-0 1999 Cutting edge: phorbol ester induction of IFN-gamma receptors leads to enhanced DR alpha gene expression. Phorbol Esters 14-27 interferon gamma Homo sapiens 41-50 10201972-1 1999 We observed that IFN-gamma-inducible expression of the DR alpha gene was enhanced when THP-1 cells are differentiated into macrophage-like cells by phorbol ester treatment. Phorbol Esters 148-161 interferon gamma Homo sapiens 17-26 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 216-229 interferon gamma Homo sapiens 191-200 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 295-308 interferon gamma Homo sapiens 118-127 10201972-2 1999 Here, we observed that class II MHC trans-activator and STAT1 alpha mRNA, mediators of the signaling cascade from the IFN-gamma receptor to the DR alpha induction, were markedly increased by IFN-gamma stimulation in phorbol ester-activated THP-1 cells; however, both mRNAs were not increased by phorbol ester treatment alone. Phorbol Esters 295-308 interferon gamma Homo sapiens 191-200 10201972-3 1999 Then, we demonstrated that the mRNA and proteins of the IFN-gamma receptor alpha- and beta-chains were amplified by phorbol ester treatment in THP-1 cells. Phorbol Esters 116-129 interferon gamma Homo sapiens 56-65 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 112-125 interferon gamma Homo sapiens 89-98 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 112-125 interferon gamma Homo sapiens 201-210 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 162-175 interferon gamma Homo sapiens 89-98 10201972-4 1999 Consequently, these results indicate that the enhancement of DR alpha gene expression by IFN-gamma treatment in phorbol ester-activated THP-1 cells is due to the phorbol ester-induced up-regulation of IFN-gamma receptor alpha- and beta-chains. Phorbol Esters 162-175 interferon gamma Homo sapiens 201-210 9119982-3 1997 Dose and time dependent increases in intracellular CB were seen when cells primed with phorbol ester (PMA) were cultured with IFN-gamma. Phorbol Esters 87-100 interferon gamma Homo sapiens 126-135 9858061-4 1998 THC decreased constitutive production of IL-8, MIP-1alpha, MIP-1beta, and RANTES and phorbol ester stimulated production of TNF-alpha, GM-CSF and IFN-gamma by NK cells. Phorbol Esters 85-98 interferon gamma Homo sapiens 146-155 9359732-6 1997 Phorbol ester and ionomycin activation also resulted in a CNI-1493 -induced inhibition of TNF-alpha in monocytes but resistant production of TNF-alpha, IL-2, and IFN-gamma by T cells. Phorbol Esters 0-13 interferon gamma Homo sapiens 162-171 8666806-6 1996 Monocytes differentiated from the IFN-gamma-transduced PBHP cells demonstrated 1) up-regulation of MHC class I and II Ag expression, 2) increased Fc(gamma)RI expression, and 3) enhanced superoxide production in response to both opsonized zymosan (25-fold) and phorbol ester (3-fold). Phorbol Esters 260-273 interferon gamma Homo sapiens 34-43 8886999-9 1996 In PBMC stimulated with phytohemagglutinin and phorbol ester, there was a decrease (72-87%) in interferon-gamma (IFN gamma) production 6 hr after IL-10 with a return to pre-IL-10 levels after 24 hr. Phorbol Esters 47-60 interferon gamma Homo sapiens 95-111 8886999-9 1996 In PBMC stimulated with phytohemagglutinin and phorbol ester, there was a decrease (72-87%) in interferon-gamma (IFN gamma) production 6 hr after IL-10 with a return to pre-IL-10 levels after 24 hr. Phorbol Esters 47-60 interferon gamma Homo sapiens 113-122 8825401-8 1996 In contrast, upon phorbol ester and ionomycin treatment, adult BMC produced more IFN-gamma mRNA than cord BMC. Phorbol Esters 18-31 interferon gamma Homo sapiens 81-90 8657115-4 1996 Phorbol ester treatment of monocytes inhibited IFN alpha-stimulated tyrosine phosphorylation of the transcription factors Stat1alpha, Stat2, and Stat3 and of the tyrosine kinase Tyk2 but had no effect on IFN-gamma activation of Stat1alpha. Phorbol Esters 0-13 interferon gamma Homo sapiens 204-213 8585942-2 1996 A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Phorbol Esters 279-292 interferon gamma Homo sapiens 144-160 8585942-2 1996 A transcription factor designated differentiation-induced factor (DIF), activated by treatment of myeloid cells with the differentiating agents interferon-gamma (IFN-gamma), granulocyte-macrophage colony-stimulating factor (GM-CSF), colony-stimulating factor-1 (CSF-1) or during phorbol ester-induced differentiation, was characterized as a 112kDa protein related to, but not identical with known isoforms of STAT 5. Phorbol Esters 279-292 interferon gamma Homo sapiens 162-171 8523577-7 1996 This IFN-gamma response element in the CAEV LTR differs from the element required for the response to phorbol esters. Phorbol Esters 102-116 interferon gamma Homo sapiens 5-14 7594575-6 1995 However, they mobilized intracellular calcium following stimulation with Ca(2+)-ionophore and produced all of the above cytokines, including IFN-gamma, when stimulated with phorbol ester and Ca2+ ionophore. Phorbol Esters 173-186 interferon gamma Homo sapiens 141-150 8120376-9 1994 Stimulation of IL2-activated NK cells with the mAb triggered TNF-alpha and IFN-gamma production, which was enhanced by using the mAb attached to plastic or in the presence of suboptimal concentrations of phorbol esters. Phorbol Esters 204-218 interferon gamma Homo sapiens 75-84 7545471-6 1995 Our results show that antiproliferative effect of IFN-gamma overrode mitogenic effect of CSF-1 and phorbol ester, as measured by early gene expression, DNA synthesis and cell proliferation. Phorbol Esters 99-112 interferon gamma Homo sapiens 50-59 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Phorbol Esters 83-96 interferon gamma Homo sapiens 167-183 7622767-2 1995 To examine the pattern of cytokine production associated with elevated IgE levels, phorbol ester plus ionomycin-stimulated production of interleukin (IL)-4, IL-5, and interferon-gamma (IFN-gamma) by blood mononuclear cells from 16 patients with atopic dermatitis was compared with that of 18 healthy subjects. Phorbol Esters 83-96 interferon gamma Homo sapiens 185-194 7622767-5 1995 Furthermore, ionomycin plus phorbol ester-stimulated mononuclear cells from patients with atopic dermatitis produced less IL-4 and more IFN-gamma than did cells from healthy subjects. Phorbol Esters 28-41 interferon gamma Homo sapiens 136-145 7947460-2 1994 We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation by phorbol ester (TPA) and calcium ionophore, indicating that these cells still have the ability to produce IFN-gamma. Phorbol Esters 117-130 interferon gamma Homo sapiens 82-91 1431124-3 1992 Phorbol esters previously have been demonstrated to increase human IFN-gamma gene expression after treatment of a murine T cell line (Cl 9) that has been transfected with human IFN-gamma genomic DNA. Phorbol Esters 0-14 interferon gamma Homo sapiens 67-76 1431124-3 1992 Phorbol esters previously have been demonstrated to increase human IFN-gamma gene expression after treatment of a murine T cell line (Cl 9) that has been transfected with human IFN-gamma genomic DNA. Phorbol Esters 0-14 interferon gamma Homo sapiens 177-186 1721013-9 1991 Io in combination with phorbol-ester induced the secretion of larger amounts of IL-4, GM-CSF, TNF-alpha and low amounts of IFN-gamma. Phorbol Esters 23-36 interferon gamma Homo sapiens 123-132 1386860-5 1992 The CD44+ population includes very immature precursor T cells and produced high titers of IL-2, TNF-alpha, and IFN-gamma upon activation with calcium ionophore and phorbol ester. Phorbol Esters 164-177 interferon gamma Homo sapiens 111-120 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Phorbol Esters 34-47 interferon gamma Homo sapiens 212-221 1292630-2 1992 Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. Phorbol Esters 175-188 interferon gamma Homo sapiens 122-149 1328343-6 1992 By contrast, stimulation with phorbol esters and ionophore, which bypass surface receptor signaling, induced comparable amounts of IL-4 and IFN-gamma in older and young subjects. Phorbol Esters 30-44 interferon gamma Homo sapiens 140-149 1628893-2 1992 When human leukaemia THP-1 and PL-21 cells were pretreated with phorbol ester, IFN-gamma-dependent induction of MHC class II gene was markedly enhanced. Phorbol Esters 64-77 interferon gamma Homo sapiens 79-88 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Phorbol Esters 156-169 interferon gamma Homo sapiens 39-55 1901779-2 1991 We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. Phorbol Esters 156-169 interferon gamma Homo sapiens 57-66 1903142-0 1991 Upregulation of interferon-gamma binding by tumor necrosis factor and lymphotoxin: disparate potencies of the cytokines and modulation of their effects by phorbol ester. Phorbol Esters 155-168 interferon gamma Homo sapiens 16-32 2104904-1 1990 We have previously shown that transfection of a plasmid clone containing full length human IFN-gamma genomic DNA into a murine T-lymphoblastoid line is followed by basal expression of the transfected gene, with increased transcription occurring upon stimulation of the cells with either phorbol ester or IL-2. Phorbol Esters 287-300 interferon gamma Homo sapiens 91-100