PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20671266-7 2010 Knockdown of Notch3 resulted in sensitization to carboplatin in OVCAR3 that expresses abundant Notch3. Carboplatin 49-60 notch receptor 3 Homo sapiens 13-19 20671266-0 2010 Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Carboplatin 95-106 notch receptor 3 Homo sapiens 0-6 20671266-5 2010 Ectopic expression of the Notch3 intracellular domain led to an increase in IC(50) for carboplatin in an ovarian surface epithelial cell line and in a low-grade serous carcinoma cell line that expressed undetectable levels of Notch3. Carboplatin 87-98 notch receptor 3 Homo sapiens 26-32 20671266-7 2010 Knockdown of Notch3 resulted in sensitization to carboplatin in OVCAR3 that expresses abundant Notch3. Carboplatin 49-60 notch receptor 3 Homo sapiens 95-101 30723507-2 2019 Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carboplatin, contributing to chemoresistance and poor survival of OC-bearing patients. Carboplatin 90-101 notch receptor 3 Homo sapiens 33-39 25010594-0 2014 Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin. Carboplatin 81-92 notch receptor 3 Homo sapiens 32-38 25010594-4 2014 Overexpression of NICD3 (the constitutively active form of Notch3) in OVCA429 ovarian cancer cells (OVCA429/NICD3) renders them resistance to carboplatin treatment compared to OVCA429/pCEG cells expressing an empty vector. Carboplatin 142-153 notch receptor 3 Homo sapiens 59-65 23542683-0 2013 Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells. Carboplatin 64-75 notch receptor 3 Homo sapiens 0-6 23542683-2 2013 Here, we investigated the role of Notch3 in carboplatin-induced apoptosis in ovarian cancer cells. Carboplatin 44-55 notch receptor 3 Homo sapiens 34-40 23542683-9 2013 Furthermore, Notch3 activation renders OVCA429 cells more resistant to carboplatin-induced cytotoxicity and attenuates carboplatin-induced apoptosis in these cells. Carboplatin 71-82 notch receptor 3 Homo sapiens 13-19 23542683-9 2013 Furthermore, Notch3 activation renders OVCA429 cells more resistant to carboplatin-induced cytotoxicity and attenuates carboplatin-induced apoptosis in these cells. Carboplatin 119-130 notch receptor 3 Homo sapiens 13-19 23542683-11 2013 Interestingly, carboplatin-induced ERK phosphorylation is inhibited by Notch3 activation. Carboplatin 15-26 notch receptor 3 Homo sapiens 71-77 23542683-12 2013 CONCLUSIONS: Notch3 activation induces EMT and attenuates carboplatin-induced apoptosis in OVCA429 cells. Carboplatin 58-69 notch receptor 3 Homo sapiens 13-19 23542683-14 2013 Interestingly, Notch3 activation attenuates carboplatin-induced ERK phosphorylation in these cells. Carboplatin 44-55 notch receptor 3 Homo sapiens 15-21