PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21562974-5 2011 LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor (Rp-cAMPS) or Akt-inhibitor (AKT 1/2 kinase inhibitor). Milrinone 37-46 AKT serine/threonine kinase 1 Rattus norvegicus 128-131 21562974-5 2011 LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor (Rp-cAMPS) or Akt-inhibitor (AKT 1/2 kinase inhibitor). Milrinone 37-46 AKT serine/threonine kinase 1 Rattus norvegicus 143-146 21562974-7 2011 This cell protective effect by esmolol + milrinone was abrogated in the presence of PKA-inhibitor or Akt-inhibitor. Milrinone 41-50 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 21562974-14 2011 CONCLUSIONS: Late-ischemia/early reperfusion therapy with esmolol + milrinone additively reduces LV-IS associated with robust activation of myocardial PKA and subsequent Akt-antiapoptotic pathway. Milrinone 68-77 AKT serine/threonine kinase 1 Rattus norvegicus 170-173