PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7832304-0	1995	Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450.	Ropivacaine	38-49	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	79-83	
7832304-3	1995	Because ropivacaine is an amide-type local anesthetic, it is metabolized by cytochrome P450 (P450) in the liver, and its elimination and plasma concentration can be dependent on the level of P450.	Ropivacaine	8-19	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	87-91	
7832304-3	1995	Because ropivacaine is an amide-type local anesthetic, it is metabolized by cytochrome P450 (P450) in the liver, and its elimination and plasma concentration can be dependent on the level of P450.	Ropivacaine	8-19	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97	
7832304-3	1995	Because ropivacaine is an amide-type local anesthetic, it is metabolized by cytochrome P450 (P450) in the liver, and its elimination and plasma concentration can be dependent on the level of P450.	Ropivacaine	8-19	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97	
7832304-4	1995	The purpose of this investigation was to elucidate the metabolism of ropivacaine by human hepatic P450.	Ropivacaine	69-80	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-102	
7832304-5	1995	METHODS: The metabolism of ropivacaine was compared using recombinant human and purified rat hepatic P450 isozymes.	Ropivacaine	27-38	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	101-105	
7832304-6	1995	An inhibition study using antibodies against rat P450 was performed using hepatic microsomes from human and rat to identify which P450s are involved in ropivacaine metabolism.	Ropivacaine	152-163	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	49-53	
7832304-16	1995	CONCLUSIONS: Ropivacaine was metabolized to PPX, 3"-OH Rop, and 4"-OH Rop by hepatic P450.	Ropivacaine	13-24	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	85-89