PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34821101-8 2021 In U2OS/DOX cells treated with ropivacaine hydrochloride, the expressions of P21, Cleaved Caspase-3, and E-cadherin were increased significantly, the expression of MMP-2 was decreased significantly, the cell proliferation inhibition rate was increased significantly, the number of colony formation was decreased significantly, and the cells apoptosis rate was increased significantly, the number of cell migration and invasion was decreased significantly, and the expression of Livin was significantly reduced, in a concentration-dependent manner (P<0.05). Ropivacaine 31-56 matrix metallopeptidase 2 Homo sapiens 164-169 35280249-7 2021 Expression of VEGF, MMP-1, MMP-2, MMP-9, and HIF-1alpha in both cell lines was also inhibited by ropivacaine in a concentration-related manner. Ropivacaine 97-108 matrix metallopeptidase 2 Homo sapiens 27-32