PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12069489-4 2002 In 1993, Ito proposed that melanogenic switching is due to the covalent binding of the intermediate DOPAquinone to the enzyme glutathione reductase. dopaquinone 100-111 glutathione-disulfide reductase Homo sapiens 126-147 8433004-8 1993 When tyrosinase activity is high, an excess of dopaquinone is produced, which results in the inactivation of glutathione reductase and gamma-glutamyl transpeptidase, enzymes essential for pheomelanogenesis. dopaquinone 47-58 glutathione-disulfide reductase Homo sapiens 109-130