PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24510561-4 2014 A CAG repeat expansion in the coding region of TBP gene can cause polyglutamine chain extension in the protein. polyglutamine 66-79 TATA-box binding protein Homo sapiens 47-50 19285969-0 2009 A splice variant of the TATA-box binding protein encoding the polyglutamine-containing N-terminal domain that accumulates in Alzheimer"s disease. polyglutamine 62-75 TATA-box binding protein Homo sapiens 24-48 22664922-2 2012 The expansion of a polyglutamine repeat in the TATA binding protein (TBP) causes a neurodegenerative disease, Spinocerebellar Ataxia 17 (SCA17). polyglutamine 19-32 TATA-box binding protein Homo sapiens 47-67 22664922-2 2012 The expansion of a polyglutamine repeat in the TATA binding protein (TBP) causes a neurodegenerative disease, Spinocerebellar Ataxia 17 (SCA17). polyglutamine 19-32 TATA-box binding protein Homo sapiens 69-72 22664922-5 2012 Here, we used a cellular model of SCA17 where we expressed TBP with 16 (normal) or 59 (pathogenic) polyglutamines and found differential expression of several microRNAs. polyglutamine 99-113 TATA-box binding protein Homo sapiens 59-62 21653638-1 2011 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 9-22 TATA-box binding protein Homo sapiens 50-74 21653638-1 2011 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 9-22 TATA-box binding protein Homo sapiens 76-80 21653638-1 2011 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 24-29 TATA-box binding protein Homo sapiens 50-74 21653638-1 2011 Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 24-29 TATA-box binding protein Homo sapiens 76-80 20226542-2 2010 Why should a polyglutamine stretch in the TATA-binding protein (that is important in all cells) particularly disrupt cerebellar coordination? polyglutamine 13-26 TATA-box binding protein Homo sapiens 42-62 12891385-7 2003 The expanded polyglutamine domain in both TBP copies is not correlated with embryonic death indicating that the normal function of the protein is not disrupted by this kind of mutation but may account for the dementia seen in this patient. polyglutamine 13-26 TATA-box binding protein Homo sapiens 42-45 18218637-2 2008 Human TBP contains a polymorphic polyglutamine (polyQ) domain in its N terminus and a DNA-binding domain in its highly conserved C terminus. polyglutamine 33-46 TATA-box binding protein Homo sapiens 6-9 17868456-1 2007 BACKGROUND: Huntington"s disease, spinal and bulbar muscular atrophy, and spinocerebellar ataxia 17 (SCA17) are caused by expansions in the polyglutamine (polyQ) repeats in Huntingtin protein (Htt), androgen receptor protein (AR), and TATA-binding protein (TBP), respectively. polyglutamine 140-153 TATA-box binding protein Homo sapiens 235-255 17868456-1 2007 BACKGROUND: Huntington"s disease, spinal and bulbar muscular atrophy, and spinocerebellar ataxia 17 (SCA17) are caused by expansions in the polyglutamine (polyQ) repeats in Huntingtin protein (Htt), androgen receptor protein (AR), and TATA-binding protein (TBP), respectively. polyglutamine 140-153 TATA-box binding protein Homo sapiens 257-260 17868456-1 2007 BACKGROUND: Huntington"s disease, spinal and bulbar muscular atrophy, and spinocerebellar ataxia 17 (SCA17) are caused by expansions in the polyglutamine (polyQ) repeats in Huntingtin protein (Htt), androgen receptor protein (AR), and TATA-binding protein (TBP), respectively. polyglutamine 155-160 TATA-box binding protein Homo sapiens 235-255 17868456-1 2007 BACKGROUND: Huntington"s disease, spinal and bulbar muscular atrophy, and spinocerebellar ataxia 17 (SCA17) are caused by expansions in the polyglutamine (polyQ) repeats in Huntingtin protein (Htt), androgen receptor protein (AR), and TATA-binding protein (TBP), respectively. polyglutamine 155-160 TATA-box binding protein Homo sapiens 257-260 17868456-8 2007 CONCLUSION: HAP1 can sequester a subset of TBP protein away from the nucleus; extranuclear TBP sequestration is quantitatively influenced by the TBP polyQ repeat. polyglutamine 149-154 TATA-box binding protein Homo sapiens 91-94 17868456-8 2007 CONCLUSION: HAP1 can sequester a subset of TBP protein away from the nucleus; extranuclear TBP sequestration is quantitatively influenced by the TBP polyQ repeat. polyglutamine 149-154 TATA-box binding protein Homo sapiens 91-94 15989694-1 2005 BACKGROUND: Spinocerebellar ataxia type 17 (SCA17), a neurodegenerative disorder in man, is caused by an expanded polymorphic polyglutamine-encoding trinucleotide repeat in the gene for TATA-box binding protein (TBP), a main transcription factor. polyglutamine 126-139 TATA-box binding protein Homo sapiens 186-210 15989694-1 2005 BACKGROUND: Spinocerebellar ataxia type 17 (SCA17), a neurodegenerative disorder in man, is caused by an expanded polymorphic polyglutamine-encoding trinucleotide repeat in the gene for TATA-box binding protein (TBP), a main transcription factor. polyglutamine 126-139 TATA-box binding protein Homo sapiens 212-215 15916858-3 2005 Wild type TBP in humans contains a long polyglutamine stretch ranging in size from 29 to 42. polyglutamine 40-53 TATA-box binding protein Homo sapiens 10-13 15916858-9 2005 The distribution of the polyglutamine coding allele lengths in TBP of the normal population and in SCA17 is reviewed and an outline is given on the reported cases of SCA17. polyglutamine 24-37 TATA-box binding protein Homo sapiens 63-66 18418687-1 2008 Spinocerebellar ataxia 17 (SCA17) or Huntington"s disease-like-4 is a neurodegenerative disease caused by the expansion above 44 units of a CAG/CAA repeat in the coding region of the TATA box binding protein (TBP) gene leading to an abnormal expansion of a polyglutamine stretch in the corresponding protein. polyglutamine 257-270 TATA-box binding protein Homo sapiens 183-207 18418687-1 2008 Spinocerebellar ataxia 17 (SCA17) or Huntington"s disease-like-4 is a neurodegenerative disease caused by the expansion above 44 units of a CAG/CAA repeat in the coding region of the TATA box binding protein (TBP) gene leading to an abnormal expansion of a polyglutamine stretch in the corresponding protein. polyglutamine 257-270 TATA-box binding protein Homo sapiens 209-212 17994014-1 2007 Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 17-30 TATA-box binding protein Homo sapiens 54-78 17994014-1 2007 Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 17-30 TATA-box binding protein Homo sapiens 80-83 17994014-1 2007 Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 32-37 TATA-box binding protein Homo sapiens 54-78 17994014-1 2007 Expansion of the polyglutamine (polyQ) tract in human TATA-box binding protein (TBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). polyglutamine 32-37 TATA-box binding protein Homo sapiens 80-83 15225551-3 2004 We show, in vitro and in cells, that monomers or small soluble oligomers of huntingtin exon1 accumulate in the nucleus and inhibit the function of TBP in a polyQ-dependent manner. polyglutamine 156-161 TATA-box binding protein Homo sapiens 147-150 15225551-5 2004 Interaction of toxic huntingtin with the benign polyQ repeat of TBP structurally destabilizes the transcription factor, independent of the formation of insoluble coaggregates. polyglutamine 48-53 TATA-box binding protein Homo sapiens 64-67 12758065-1 2003 Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). polyglutamine 77-90 TATA-box binding protein Homo sapiens 142-166 12758065-1 2003 Recently, an inherited spinocerebellar ataxia (SCA17) has been attributed to polyglutamine coding expansions within the gene coding for human TATA-box binding protein (TBP). polyglutamine 77-90 TATA-box binding protein Homo sapiens 168-171 12758065-8 2003 As TBP is required for transcription by all RNA polymerases, this may indicate a mechanism for aberrant polyQ gain of function. polyglutamine 104-109 TATA-box binding protein Homo sapiens 3-6 30760647-1 2019 Spinocerebellar ataxia (SCA) type 17 is an autosomal dominant ataxia caused by expanded polyglutamine (polyQ) tract in the TATA-box binding protein (TBP). polyglutamine 88-101 TATA-box binding protein Homo sapiens 123-147 11448935-0 2001 SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. polyglutamine 74-87 TATA-box binding protein Homo sapiens 91-111 12235815-0 2001 [SCA17, a novel polyglutamine disease caused by the expansion of polyglutamine tracts in TATA-binding protein]. polyglutamine 16-29 TATA-box binding protein Homo sapiens 89-109 10484774-0 1999 A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease? polyglutamine 110-123 TATA-box binding protein Homo sapiens 77-97 10484774-2 1999 The mutant TBP with an expanded polyglutamine stretch (63 glutamines) was demonstrated to be expressed in lymphoblastoid cell lines at a level comparable with that of wild-type TBP. polyglutamine 32-45 TATA-box binding protein Homo sapiens 11-14 8886170-0 1996 Analysis of polyglutamine-coding repeats in the TATA-binding protein in different human populations and in patients with schizophrenia and bipolar affective disorder. polyglutamine 12-25 TATA-box binding protein Homo sapiens 48-68 8886170-4 1996 We and others believe that the TATA-binding protein (TBP) is an important candidate to investigate in these diseases as it contains a highly polymorphic stretch of glutamine codons, which are close to the threshold length where the polyglutamine tracts start to be associated with disease. polyglutamine 232-245 TATA-box binding protein Homo sapiens 31-51 8886170-4 1996 We and others believe that the TATA-binding protein (TBP) is an important candidate to investigate in these diseases as it contains a highly polymorphic stretch of glutamine codons, which are close to the threshold length where the polyglutamine tracts start to be associated with disease. polyglutamine 232-245 TATA-box binding protein Homo sapiens 53-56 34906452-0 2022 Digenic inheritance of STUB1 variants and TBP polyglutamine expansions explains the incomplete penetrance of SCA17 and SCA48. polyglutamine 46-59 TATA-box binding protein Homo sapiens 42-45 34906452-1 2022 PURPOSE: This study aimed to unravel the genetic factors underlying missing heritability in spinocerebellar ataxia type 17 (SCA17) caused by polyglutamine-encoding CAG/CAA repeat expansions in the TBP gene. polyglutamine 141-154 TATA-box binding protein Homo sapiens 197-200 31317427-1 2019 Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. polyglutamine 52-65 TATA-box binding protein Homo sapiens 91-115 31317427-1 2019 Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. polyglutamine 52-65 TATA-box binding protein Homo sapiens 117-120 31317427-1 2019 Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. polyglutamine 67-72 TATA-box binding protein Homo sapiens 91-115 31317427-1 2019 Spinocerebellar ataxia type 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP), which functions as a general transcription factor. polyglutamine 67-72 TATA-box binding protein Homo sapiens 117-120 31317427-4 2019 The well-characterized function of TBP and typical neurodegeneration in SCA17 give us opportunities to understand how polyQ expansion causes selective neurodegeneration and to develop effective therapeutics. polyglutamine 118-123 TATA-box binding protein Homo sapiens 35-38 30707359-7 2019 We show its usefulness by performing a comparative study of the interactome of the nine polyglutamine (polyQ) disease proteins, namely androgen receptor (AR), atrophin-1 (ATN1), ataxin 1 (ATXN1), ataxin 2 (ATXN2), ataxin 3 (ATXN3), ataxin 7 (ATXN7), calcium voltage-gated channel subunit alpha1 A (CACNA1A), Huntingtin (HTT), and TATA-binding protein (TBP). polyglutamine 88-101 TATA-box binding protein Homo sapiens 330-350 30707359-7 2019 We show its usefulness by performing a comparative study of the interactome of the nine polyglutamine (polyQ) disease proteins, namely androgen receptor (AR), atrophin-1 (ATN1), ataxin 1 (ATXN1), ataxin 2 (ATXN2), ataxin 3 (ATXN3), ataxin 7 (ATXN7), calcium voltage-gated channel subunit alpha1 A (CACNA1A), Huntingtin (HTT), and TATA-binding protein (TBP). polyglutamine 88-101 TATA-box binding protein Homo sapiens 352-355 30760647-1 2019 Spinocerebellar ataxia (SCA) type 17 is an autosomal dominant ataxia caused by expanded polyglutamine (polyQ) tract in the TATA-box binding protein (TBP). polyglutamine 88-101 TATA-box binding protein Homo sapiens 149-152 29936316-4 2018 We found that both aggregation and polyQ-induced reactive oxygen species can be significantly prohibited by the tested NC009 compounds in Tet-On TBP/Q79 293 cells. polyglutamine 35-40 TATA-box binding protein Homo sapiens 145-148 30473770-3 2018 Polyglutamine (polyQ) expansion diseases ( ATXN1/SCA1, ATXN2/SCA2, ATXN3/SCA3, CACNA1A/SCA6, ATXN7/SCA7, TBP/SCA17, and ATN1/DRPLA) are the most common group of SCAs. polyglutamine 0-13 TATA-box binding protein Homo sapiens 105-108 29427105-1 2018 In 1999, a polyglutamine expansion was identified in the transcription factor TATA-binding protein (TBP) in a patient with ataxia with negative family history. polyglutamine 11-24 TATA-box binding protein Homo sapiens 78-98 29427105-1 2018 In 1999, a polyglutamine expansion was identified in the transcription factor TATA-binding protein (TBP) in a patient with ataxia with negative family history. polyglutamine 11-24 TATA-box binding protein Homo sapiens 100-103 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 145-158 TATA-box binding protein Homo sapiens 91-115 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 145-158 TATA-box binding protein Homo sapiens 117-120 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 145-158 TATA-box binding protein Homo sapiens 180-183 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 145-158 TATA-box binding protein Homo sapiens 180-183 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 160-165 TATA-box binding protein Homo sapiens 91-115 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 160-165 TATA-box binding protein Homo sapiens 117-120 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 160-165 TATA-box binding protein Homo sapiens 180-183 25342886-1 2014 In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. polyglutamine 160-165 TATA-box binding protein Homo sapiens 180-183 25342886-4 2014 We found that indole and NC001-8 up-regulated chaperone expression to reduce polyQ aggregation in neuronal differentiated TBP/Q79 cells. polyglutamine 77-82 TATA-box binding protein Homo sapiens 122-125 28821675-0 2017 Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17. polyglutamine 24-37 TATA-box binding protein Homo sapiens 47-67 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 47-60 TATA-box binding protein Homo sapiens 93-113 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 47-60 TATA-box binding protein Homo sapiens 115-118 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 62-67 TATA-box binding protein Homo sapiens 93-113 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 62-67 TATA-box binding protein Homo sapiens 115-118 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 181-186 TATA-box binding protein Homo sapiens 93-113 28821675-1 2017 Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in the brain. polyglutamine 181-186 TATA-box binding protein Homo sapiens 115-118 28821675-8 2017 Our results indicate that the synergistic toxicity of mutant TBP in neuronal and glial cells plays a critical role in SCA17 pathogenesis and that targeting glial inflammation could be a potential therapeutic approach for SCA17 treatment.SIGNIFICANCE STATEMENT Mutant TBP with polyglutamine expansion preferentially affects neuronal viability in SCA17 patients. polyglutamine 276-289 TATA-box binding protein Homo sapiens 61-64 27520369-2 2016 Using these immunoassays, we now report that polyglutamine expansion influences the conformational properties of other polyglutamine disease proteins, exemplified by the androgen receptor (associated with spinal bulbar muscular atrophy) and TATA binding protein (associated with spinocerebellar ataxia 17). polyglutamine 45-58 TATA-box binding protein Homo sapiens 241-304