PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11111157-11 2000 In future studies, it will be important to determine whether transglutaminases play a role in (1) cross-linking of histone H1 to glutaminyl donors (including polyglutamine domains) in nuclear chromatin, (2) the formation of nuclear aggregates in (CAG)(n)/polyglutamine expansion diseases, (3) DNA laddering and cell death in neurodegenerative diseases and (4) depletion of neuropeptides in vulnerable regions of Huntington"s disease brain. polyglutamine 255-268 H1.0 linker histone Homo sapiens 115-125