PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17826765-6 2007 Fos-immunoreactivity induced by acute apomorphine administration (barrel cortex, paraventricular hypothalamic nucleus, central amygdala and locus coeruleus) was strongly reduced after chronic administration. Apomorphine 38-49 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 21365203-2 2011 In rats, the dopamine agonist, apomorphine (APO), reduces PPI and expression of the early gene, c-fos, within the nucleus accumbens (NAC) core. Apomorphine 31-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 96-101 19094973-9 2009 Additionally, when comparing Fos IR in selected brain regions, these animals displayed altered basal neuronal activity and responded differently to acute application of haloperidol or apomorphine. Apomorphine 184-195 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-32 32200030-7 2020 Early flupenthixol treatment was associated with more apomorphine-induced c-Fos labeling in the nucleus accumbens shell than the early saline-apomorphine group, indicating a sensitized response. Apomorphine 54-65 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 74-79 17826765-8 2007 Apomorphine, however, reduced mating-induced Fos-immunoreactivity in the nucleus accumbens shell and prevented its occurrence in its core area. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 45-48 11070194-7 2000 Repeated administration of methyl levodopa resulted in diminished apomorphine sensitivity of Fos expression in the dopamine depleted caudate-putamen and in enhanced sensitivity in the globus pallidus of the same side. Apomorphine 66-77 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 93-96 15978010-4 2005 The mixed dopamine agonist apomorphine increased Fos expression in orexin cells, with a greater effect on orexin neurons located medial to the fornix. Apomorphine 27-38 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 49-52 12812860-7 2003 Intravascular administration of apomorphine had no effect on basal ACTH levels but did substantially increase the number of Fos-positive amygdala and nucleus tractus solitarius catecholamine cells. Apomorphine 32-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 124-127 12812860-8 2003 Administration of apomorphine prior to immune challenge augmented the normal ACTH response to this stressor at 90 min and there was a corresponding increase in the number of Fos-positive paraventricular nucleus corticotropin-releasing factor cells, paraventricular nucleus oxytocin cells and nucleus tractus solitarius catecholamine cells. Apomorphine 18-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 174-177 11282380-1 2001 Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Apomorphine 57-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 185-188 11682155-0 2001 Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior. Apomorphine 107-118 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 14-19 11682155-1 2001 Apomorphine-evoked expression of transcription factor proteins: c-Fos, Fos B, Jun B, and Zif268 (also named Krox-24, NGFI-A, Egr-1), was investigated in rat somatosensory (barrel) cortex. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-69 11682155-6 2001 In contrast, apomorphine (5.0 mg/kg) evoked marked c-Fos elevation, less pronounced changes in Jun B and Zif268 and no change in Fos B. Apomorphine 13-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 51-56 11682155-6 2001 In contrast, apomorphine (5.0 mg/kg) evoked marked c-Fos elevation, less pronounced changes in Jun B and Zif268 and no change in Fos B. Apomorphine 13-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-56 11682155-7 2001 The greatest apomorphine-evoked c-Fos accumulation was observed in layers IV and V/VI of non-deprived barrel cortex and was not significantly influenced by MK-801 injection at 0.1 mg/kg. Apomorphine 13-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 15700284-3 2005 Priming induction using three injections with D1/D2 agonist apomorphine (0.5 mg/kg) or D1 agonist SKF38393 (10 mg/kg) allows priming expression, robust contralateral rotational behavior and striatal Fos expression, following a challenge with the D2 agonist quinpirole (0.25 mg/kg). Apomorphine 60-71 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 199-202 10579212-3 1999 Our prior work has shown that three pretreatment injections of the mixed D1/D2 agonist apomorphine (0.5 mg/kg) into 6-hydroxydopamine-lesioned rats permits a previously inactive dose of the D2 agonist quinpirole (0.25 mg/kg) to induce robust contralateral rotation and striatal Fos expression in striatoentopeduncular "direct" pathway neurons. Apomorphine 87-98 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 278-281 10320705-2 1999 Previously, we have shown that 6-OHDA rats primed with three injections of the D1/D2 dopamine agonist apomorphine (0.5 mg/kg) permitted a challenge with an otherwise inactive dose of the D2 agonist quinpirole (0.25 mg/kg) to elicit robust rotational behavior and to induce Fos expression in striatoentopeduncular neurons. Apomorphine 102-113 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 273-276 10408602-5 1999 Apomorphine and quinpirole increased the discharge rate and induced a strong expression of c-Fos-like immunoreactive proteins, whereas SKF 82958 induced a decrease of the discharge rate and a slight expression of c-Fos in 6-hydroxydopamine-lesioned rats. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 91-96 10408602-5 1999 Apomorphine and quinpirole increased the discharge rate and induced a strong expression of c-Fos-like immunoreactive proteins, whereas SKF 82958 induced a decrease of the discharge rate and a slight expression of c-Fos in 6-hydroxydopamine-lesioned rats. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 213-218 10904129-2 2000 In the current study we extended these observations by using a quantitative technique to demonstrate that while amphetamine and apomorphine produce patchy striatal Fos expression, the selective dopamine uptake inhibitors amfonelic acid, nomifensine and GBR-12909 all, like cocaine, produce near random patterns of gene expression. Apomorphine 128-139 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 164-167 10216178-0 1999 Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment. Apomorphine 118-129 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 39-44 10216178-2 1999 In order to understand striatal mechanisms behind this long-term behavioral change we examined striatal c-Fos and FosB immunoreactivity induced by apomorphine challenge (5 mg/kg, s.c.) after 3 days of withdrawal following a 2-week administration (5 mg/kg, b.i.d., s.c.) both in intact and 6-OHDA-lesioned animals. Apomorphine 147-158 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 104-109 10216178-3 1999 In intact rats, c-Fos induction by acute apomorphine exposure showed a striosomal pattern, whereas FosB immunopositivity was diffusely distributed. Apomorphine 41-52 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 16-21 7915411-10 1994 However, apomorphine induced a considerable number of Fos-positive nuclei in striatal grafts at three and four weeks after grafting. Apomorphine 9-20 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 54-57 9465005-4 1998 It was also examined in lesioned rats whether the grafts may regulate the expression of c-Fos after systemic administration of apomorphine in the basal ganglia nuclei as well as their target structures, including the ventromedial thalamic nucleus (VM), superior colliculus (SC), and pedunculopontine nucleus (PPN). Apomorphine 127-138 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 88-93 9465005-7 1998 Apomorphine induced an increased expression of c-Fos in the GP, STN, VM, SC, and PPN on the lesioned side. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 47-52 8723713-5 1996 All DA agonists significantly increased c-fos levels after apomorphine injection. Apomorphine 59-70 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 40-45 8710170-5 1996 Both in animals with intrathalamic and in animals with intracortical grafts, systemic administration of a low dose of apomorphine (0.25 mg/kg) induced intense fos expression in striatum-like patches not innervated by dopaminergic fibres. Apomorphine 118-129 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 159-162 8721156-2 1996 Apomorphine at a low dosage (0.25 mg/kg) induced contraversive rotation and supersensitive striatal Fos expression that were detected 24-48 h post-lesion and gradually increased in magnitude. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 100-103 8721156-6 1996 Seven and 14 days after lesion the loss of TH immunoreactivity and apomorphine-induced supersensitive Fos expression were more evenly distributed, and amphetamine induced only ipsiversive rotation and a low density of Fos-positive nuclei in the denervated striatum. Apomorphine 67-78 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 102-105 9324226-0 1997 Differential effect of sensitizing regimen on induction of Fos-protein and locomotor activity elicited by apomorphine in rats. Apomorphine 106-117 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 59-62 9324226-2 1997 The purpose of this study was to determine whether apomorphine induces Fos-protein in animals sensitized by repeated treatment with apomorphine and whether the magnitude of such induction parallels the magnitude of behavioral response observed after different sensitizing paradigms. Apomorphine 51-62 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 71-74 9324226-3 1997 Apomorphine did induce Fos-protein expression in animals pretreated with apomorphine; however, the rats showing highest levels of induction were not those showing the largest behavioral responses. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-26 9324226-3 1997 Apomorphine did induce Fos-protein expression in animals pretreated with apomorphine; however, the rats showing highest levels of induction were not those showing the largest behavioral responses. Apomorphine 73-84 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-26 9178866-6 1997 Administration of apomorphine (0.5 mg/kg; three injections at three to six day intervals) permitted an otherwise inactive dose of quinpirole (0.25 mg/kg) to produce robust contralateral rotation and to induce the expression of Fos in striatal neurons belonging to the striato-nigro-entopeduncular ("direct") pathway. Apomorphine 18-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 227-230 9178866-8 1997 Apomorphine priming also enhanced the ability of quinpirole to induce Fos expression in the globus pallidus, a target of the striatopallidal ("indirect") pathway. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 70-73 8883820-4 1996 Thus, MK 801 reduced in the expression phase of priming the stimulation of Fos expression by apomorphine in the dorsolateral caudate-putamen, but did not affect that by SKF 38393. Apomorphine 93-104 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-78 8883820-6 1996 MK 801, given with apomorphine in the induction phase, reduced the stimulation of Fos expression in the dorsolateral caudate-putamen by SKF 38393. Apomorphine 19-30 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 82-85 8577370-13 1995 The intrathalamic grafts of rats which had received a low dose of apomorphine (0.25 mg/kg) 2 h before perfusion showed clusters of intensely Fos-immunoreactive nuclei throughout the transplant, indicating that these cells had developed dopamine receptors and supersensitivity to dopamine agonists. Apomorphine 66-77 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 141-144 7482290-3 1995 Fos immunoreactivity induced by d-amphetamine (5 mg/kg) or apomorphine (5 mg/kg) was quantified in dorsolateral and ventrolateral regions of caudate-putamen (CPu) in rats still demonstrating sensory neglect (5 days postsurgery) and in rats recovered from sensory neglect produced by AGm ablation (29+ days postsurgery). Apomorphine 59-70 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 7482290-5 1995 In rats demonstrating sensory neglect, d-amphetamine or apomorphine induction of Fos in the ipsilateral CPu was reduced by about 40% compared to the contralateral CPu or to comparable readings in unlesioned controls. Apomorphine 56-67 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 81-84 7538563-9 1995 Amphetamine-induced striatal Fos expression was normalized in the caudate-putamen ipsilateral to the intranigral VM grafts, showing hyperexpression in some areas of the striatum, and the apomorphine-induced Fos expression seen in the 6-OHDA-lesioned animals was completely reversed on the grafted side. Apomorphine 187-198 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-32 7477877-6 1995 It was demonstrated that in drug-naive rats bearing unilateral 6-hydroxydopamine lesions of the dopaminergic nigrostriatal pathway, the mixed D1/D2 agonist apomorphine produced a dramatic increase in the expression of Fos-like immunoreactivity in the ipsilateral caudoputamen, nucleus accumbens and globus pallidus, and was a potent primer of SKF-38393-mediated rotational behaviour. Apomorphine 156-167 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 218-221 7477877-8 1995 Preadministration of MK-801 at 0.5 mg/kg significantly reduced apomorphine"s effect on Fos expression and prevented apomorphine priming of SKF-38393-induced rotation. Apomorphine 63-74 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 87-90 7477877-14 1995 Northern blot analysis demonstrated that a priming dose of apomorphine significantly increased the messenger RNA signals for c-fos, c-jun, ngfi-A and jun-B in denervated striatum. Apomorphine 59-70 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 125-130 8077463-5 1994 Injection of apomorphine (5 mg/kg) resulted in increased expression of both c-fos and zif268 immediate-early genes in cortex and striatum. Apomorphine 13-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 76-81 8298093-0 1993 c-fos antisense generates apomorphine and amphetamine-induced rotation. Apomorphine 26-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 8137158-1 1994 In rats treated systemically with either amphetamine, amfonelic acid or apomorphine, large numbers of cells displaying Fos-like immunoreactivity (FLI) could be seen in the lateral zone of the lateral habenula. Apomorphine 72-83 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 119-122 8298093-5 1993 These results suggest that antisense to c-fos produces a biochemical change in the injected striatum that then, 10 h later, blocks amphetamine- and apomorphine-induced behavioural and biochemical effects. Apomorphine 148-159 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 40-45 12106364-5 1992 Cocaine induced a proportionally higher c-fos expression in striato-nigral compared to striato-pallidal neurons, whereas apomorphine activated Fos almost exclusively in striato-nigral neurons. Apomorphine 121-132 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 143-146 8281310-0 1993 Transection of corticostriatal afferents reduces amphetamine- and apomorphine-induced striatal Fos expression and turning behaviour in unilaterally 6-hydroxydopamine-lesioned rats. Apomorphine 66-77 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 95-98 8281310-8 1993 The frontocortical transection reduced both apomorphine- and amphetamine-induced Fos expression by 33-66% within the ipsilateral caudate-putamen. Apomorphine 44-55 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 81-84 1504828-6 1992 Two to 3 weeks after a 6-OHDA lesion of the host DA pathway (i.e. a time sufficient for DA receptor supersensitivity to develop), apomorphine-induced extensive Fos-activation selectively within the DARPP-32-positive areas of the graft. Apomorphine 130-141 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 160-163 1504828-9 1992 In intrastriatal grafts of fetal neocortical tissue, which were studied for comparison, the amphetamine- and apomorphine-induced effects on Fos expression were much smaller and similar to that seen in the DARPP-32-negative, non-striatal compartment within the striatal grafts. Apomorphine 109-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 140-143 1347413-0 1992 Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum. Apomorphine 52-63 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-75 1347413-2 1992 The pattern of striatal Fos expression after systemic administration of either the dopamine receptor agonist, apomorphine, or the dopamine-releasing agent, amphetamine, was studied in rats which had received cell suspension grafts of fetal ventral mesencephalic neurons into the striatum after a complete 6-hydroxydopamine lesion of mesostriatal dopaminergic projection. Apomorphine 110-121 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 24-27 1347413-10 1992 Apomorphine led to high Fos activation throughout the dopamine-depleted caudate-putamen, whereas only very few immunopositive cells were observed in the intact caudate-putamen. Apomorphine 0-11 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 24-27 1347413-12 1992 In the grafted rats, apomorphine-induced Fos activation was similar to normal in all striatal areas sampled, as well as in the globus pallidus. Apomorphine 21-32 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 41-44