PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34685689-7 2021 In addition, ADAM15 reinforces the Src-mediated activation of pannexin-1 channels required for the enhanced release of ATP, a mediator of purinergic inflammation, which is increasingly produced upon sirtuin-1 induction. Adenosine Triphosphate 119-122 sirtuin 1 Homo sapiens 199-208 32022249-12 2020 SIRT1-LKB1-AMPK-SREBP1 axis-mediated lipid accumulation in HepG2 cells was reduced, when HepG2 cells were cultured with conditioned medium from LPS/ATP-activated THP-1 macrophages pretreated with 2354glu. Adenosine Triphosphate 148-151 sirtuin 1 Homo sapiens 0-5 34222486-7 2021 We then used a Seahorse XFe24 analyzer to measure the bioenergetic parameters of NP cells and obtained three findings: (a) glycolysis is the main energy metabolism pathway in NP cells, (b) there is a large difference in ATP production between senescent cells and young cells, and (c) SIRT1 can regulate the production of ATP from glycolysis by regulating LDHA. Adenosine Triphosphate 220-223 sirtuin 1 Homo sapiens 284-289 34222486-7 2021 We then used a Seahorse XFe24 analyzer to measure the bioenergetic parameters of NP cells and obtained three findings: (a) glycolysis is the main energy metabolism pathway in NP cells, (b) there is a large difference in ATP production between senescent cells and young cells, and (c) SIRT1 can regulate the production of ATP from glycolysis by regulating LDHA. Adenosine Triphosphate 321-324 sirtuin 1 Homo sapiens 284-289 33063092-9 2020 It conserves NAD+ and prevents ATP depletion by PARP 1 and Sirtuin 1 (silent mating type information regulation 2 homologue 1) inhibition, enhances NAD+ synthesis, and hence that of NADP+ which is a stronger PARP inhibitor, reverses lung injury caused by ischaemia/reperfusion, inhibits proinflammatory cytokines and is effective against HIV infection. Adenosine Triphosphate 31-34 sirtuin 1 Homo sapiens 59-68 35134563-6 2022 ATP and NADH, derivatives of adenosine, inhibit insulin signaling inside cells by downregulation of activities of AMPK and SIRT1, respectively. Adenosine Triphosphate 0-3 sirtuin 1 Homo sapiens 123-128 27908642-7 2017 Importantly, gene silencing of SIRT1 abrogated the inhibitory effect of SIRT1 activator on NLRP3 inflammasome formation and IL-1beta production in HUVECs stimulated with LPS plus ATP. Adenosine Triphosphate 179-182 sirtuin 1 Homo sapiens 31-36 32106265-6 2020 Furthermore, the oxygen consumption rate (OCR) was reduced as assessed in Seahorse assays, coupled with lower levels of ATP in SIRT1-/- DC. Adenosine Triphosphate 120-123 sirtuin 1 Homo sapiens 127-132 31072928-8 2019 In vivo studies revealed that 5-HT2A receptor stimulation increased cortical mtDNA and ATP levels in a SIRT1-dependent manner. Adenosine Triphosphate 87-90 sirtuin 1 Homo sapiens 103-108 28504272-0 2017 Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins. Adenosine Triphosphate 28-31 sirtuin 1 Homo sapiens 0-5 28504272-3 2017 Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal domain (CTD) of Sirt1. Adenosine Triphosphate 54-57 sirtuin 1 Homo sapiens 21-26 28504272-3 2017 Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal domain (CTD) of Sirt1. Adenosine Triphosphate 54-57 sirtuin 1 Homo sapiens 105-110 28504272-4 2017 ATP suppresses Sirt1 activity by impairing the CTD"s ability to bind to the deacetylase domain as well as its ability to function as the substrate recruitment site. Adenosine Triphosphate 0-3 sirtuin 1 Homo sapiens 15-20 28504272-6 2017 Mutations that prevent ATP binding increase Sirt1"s ability to promote stress resistance and inhibit adipogenesis under high-ATP conditions. Adenosine Triphosphate 23-26 sirtuin 1 Homo sapiens 44-49 28504272-6 2017 Mutations that prevent ATP binding increase Sirt1"s ability to promote stress resistance and inhibit adipogenesis under high-ATP conditions. Adenosine Triphosphate 125-128 sirtuin 1 Homo sapiens 44-49 28339017-10 2017 Knockdown of SIRT1 suppressed the effect of polydatin on mitochondrial TFAM, mtDNA content and cellular ATP levels. Adenosine Triphosphate 104-107 sirtuin 1 Homo sapiens 13-18 31163574-7 2019 Additionally, several sessions of exercise (training) activates SIRT1 and also SIRT3 that, together with the biogenesis and mitochondrial oxidative function, jointly activate ATP production and the mitochondrial antioxidant function. Adenosine Triphosphate 175-178 sirtuin 1 Homo sapiens 64-69 30512225-6 2019 When transfected into HEK293T cells, EF-sir2 could significantly facilitate aerobic oxidation of glucose, enhance the respiration to generate more ATP, and cause upregulation of NRF1 target gene. Adenosine Triphosphate 147-150 sirtuin 1 Homo sapiens 40-44 30591661-0 2018 A Rise in ATP, ROS, and Mitochondrial Content upon Glucose Withdrawal Correlates with a Dysregulated Mitochondria Turnover Mediated by the Activation of the Protein Deacetylase SIRT1. Adenosine Triphosphate 10-13 sirtuin 1 Homo sapiens 177-182 30591661-4 2018 The results of our study indicate a substantial increase in ATP production from mitochondria, through an elevation of mitochondrial biogenesis, mediated by SIRT1 activation that is driven by increased NAD+/NADH ratio. Adenosine Triphosphate 60-63 sirtuin 1 Homo sapiens 156-161 29717261-11 2018 Consequently, blocking the CD105-SIRT1 axis was found to deplete the ATP stores of irradiated cells and cause G2 cell cycle arrest. Adenosine Triphosphate 69-72 sirtuin 1 Homo sapiens 33-38 29712732-4 2018 In the kidney, the most widely studied sirtuin is SIRT1, which exerts cytoprotective effects by inhibiting cell apoptosis, inflammation, and fibrosis together with SIRT3, a crucial metabolic sensor that regulates ATP generation and mitochondrial adaptive response to stress. Adenosine Triphosphate 213-216 sirtuin 1 Homo sapiens 50-55 27908642-7 2017 Importantly, gene silencing of SIRT1 abrogated the inhibitory effect of SIRT1 activator on NLRP3 inflammasome formation and IL-1beta production in HUVECs stimulated with LPS plus ATP. Adenosine Triphosphate 179-182 sirtuin 1 Homo sapiens 72-77 27081083-5 2016 SIRT1 depletion attenuated mitochondrial biogenesis and adenosine triphosphate (ATP) production but did not affect epithelial-mesenchymal transition. Adenosine Triphosphate 80-83 sirtuin 1 Homo sapiens 0-5 27614220-6 2016 Moreover, NA administration up-regulated SIRT1 expression in HUVECs stimulated with LPS plus ATP. Adenosine Triphosphate 93-96 sirtuin 1 Homo sapiens 41-46 27505710-6 2016 Moreover, SIRT1 expression was reduced in HUVECs stimulated with LPS and ATP. Adenosine Triphosphate 73-76 sirtuin 1 Homo sapiens 10-15 27505710-7 2016 SIRT1 activator inhibited the expression of monocyte chemotactic protein-1 (MCP-1) and C-reactive protein (CRP), whereas SIRT1 knockdown resulted in significant increases in MCP-1 and CRP levels in HUVECs stimulated with LPS and ATP. Adenosine Triphosphate 229-232 sirtuin 1 Homo sapiens 0-5 27081083-5 2016 SIRT1 depletion attenuated mitochondrial biogenesis and adenosine triphosphate (ATP) production but did not affect epithelial-mesenchymal transition. Adenosine Triphosphate 56-78 sirtuin 1 Homo sapiens 0-5 21873234-5 2011 BATF, together with c-Jun, transcriptionally inhibited expression of the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase Sirt1, resulting in increased histone acetylation of the T-bet locus and increased cellular NAD(+), which increased ATP production. Adenosine Triphosphate 254-257 sirtuin 1 Homo sapiens 138-143 26020938-5 2015 The proposed model involves two DNA damage response proteins, SIRT1 and PARP1, that are each consumers of nicotinamide adenine dinucleotide (NAD), a metabolite involved in oxidation-reduction reactions and in ATP synthesis. Adenosine Triphosphate 209-212 sirtuin 1 Homo sapiens 62-67 22674476-2 2012 Caloric restriction activates both AMPK and SIRT-1 to increase ATP production from fat oxidation. Adenosine Triphosphate 63-66 sirtuin 1 Homo sapiens 44-50