PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24824795-1	2014	Functional morphodynamic behavior of differentiated macrophages is strongly controlled by actin cytoskeleton rearrangements, a process in which also metabolic cofactors ATP and NAD(H) (i.e. NAD+ and NADH) and NADP(H) (i.e. NADP+ and NADPH) play an essential role.	Adenosine Triphosphate	169-172	2,4-dienoyl-CoA reductase 1	Homo sapiens	223-238	
17699635-5	2007	Our method utilizes a two-enzyme system that generates NADPH when ATP is present.	Adenosine Triphosphate	66-69	2,4-dienoyl-CoA reductase 1	Homo sapiens	55-60	
23296366-5	2013	Other examples are the epimerase and the ATP-dependent dehydratase that repair hydrated forms of NADH and NADPH; ethylmalonyl-CoA decarboxylase, which eliminates an abnormal metabolite formed by acetyl-CoA carboxylase, an enzyme of fatty acid synthesis; L-pipecolate oxidase, which repairs a metabolite formed by a side activity of an enzyme of L-proline biosynthesis.	Adenosine Triphosphate	41-44	2,4-dienoyl-CoA reductase 1	Homo sapiens	106-111	
17989923-6	2008	The metabolic model predicted the involvement of a transhydrogenase that generates additional NADH from NADPH, thereby increasing ATP regeneration in the respiratory chain.	Adenosine Triphosphate	130-133	2,4-dienoyl-CoA reductase 1	Homo sapiens	104-109	
35367765-1	2022	Under the dysfunction of mitochondria, cancer cells preferentially utilize both glycolytic and pentose phosphate pathways rather than electron transport chains to desperately generate adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH), classically recognized as the Warburg effect.	Adenosine Triphosphate	208-211	2,4-dienoyl-CoA reductase 1	Homo sapiens	277-282	
16228610-2	2004	The following functions have been proposed for these pathways: adjustment of ATP/NADPH ratio required for CO(2) fixation, generation of the proton gradient for the down-regulation of Photosystem II (PS II), and ATP supply the active transport of inorganic carbon in algal cells.	Adenosine Triphosphate	211-214	2,4-dienoyl-CoA reductase 1	Homo sapiens	81-86	
15231280-5	2004	We argue that chloroplasts need two types of flexible mechanisms: one for modulating the output ratio of ATP:NADPH, which involves cyclic electron flux around photosystem I; and another for changing the regulatory sensitivity of the light-harvesting antenna to electron (and proton) flow.	Adenosine Triphosphate	105-108	2,4-dienoyl-CoA reductase 1	Homo sapiens	109-114	
7284486-6	1981	When the NADPH concentration is decreased below 80% of the physiological value, the system ceases to stabilize the ATP concentration.	Adenosine Triphosphate	115-118	2,4-dienoyl-CoA reductase 1	Homo sapiens	9-14	
34664348-1	2022	Many existing in vitro biosystems harness power from the chemical energy contained in substrates and co-substrates, and light or electric energy provided from abiotic parts, leading to a compromise in atom economy, incompatibility between biological and abiotic parts, and most importantly, incapability to spatiotemporally co-regenerate ATP and NADPH.	Adenosine Triphosphate	338-341	2,4-dienoyl-CoA reductase 1	Homo sapiens	346-351	
2441031-0	1987	The role of NADPH- and reduced glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent, hepatic microsomal calcium pump: a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte.	Adenosine Triphosphate	101-104	2,4-dienoyl-CoA reductase 1	Homo sapiens	12-17	
2567735-2	1989	In the present work we found that the kinase, in the absence or presence of the reductase (and in the absence of NADPH), catalyzes stoichiometric formation of 5-oxo-L-proline and Pi from L-glutamate and ATP, but catalyzes hydroxamate formation at only about 10% of the rate of ATP-cleavage.	Adenosine Triphosphate	203-206	2,4-dienoyl-CoA reductase 1	Homo sapiens	113-118	
2567735-2	1989	In the present work we found that the kinase, in the absence or presence of the reductase (and in the absence of NADPH), catalyzes stoichiometric formation of 5-oxo-L-proline and Pi from L-glutamate and ATP, but catalyzes hydroxamate formation at only about 10% of the rate of ATP-cleavage.	Adenosine Triphosphate	277-280	2,4-dienoyl-CoA reductase 1	Homo sapiens	113-118	
3519822-4	1986	We observed that: the effect of glucose on mononuclear cell cortisol metabolism was not influenced by insulin; NADPH and NADH enhanced cortisol metabolism by disrupted cells, irrespective of whether the homogenates were dialysed or not; lactate and ATP inhibited mononuclear cell cortisol metabolism and almost all the glucose used was converted to lactate.	Adenosine Triphosphate	249-252	2,4-dienoyl-CoA reductase 1	Homo sapiens	111-116	
31604821-8	2019	In both tumor and healthy cells, V-ATPase inhibition induced a distinct metabolic regulatory cascade downstream of AMPK, affecting ATP and NADPH levels, glucose uptake, and reactive oxygen species (ROS) production.	Adenosine Triphosphate	35-38	2,4-dienoyl-CoA reductase 1	Homo sapiens	139-144	
32816875-3	2021	These accelerated metabolic processes require energy in the form of ATP and reducing equivalents in the form of NADPH, which power biosynthetic reactions and buffer oxidative stress encountered by the metabolically active cancer cell.	Adenosine Triphosphate	68-71	2,4-dienoyl-CoA reductase 1	Homo sapiens	112-117