PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31175486-1	2019	ATP acts as a canonical activator to induce NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome activation in macrophages, leading to caspase-1/gasdermin D (GSDMD)-mediated pyroptosis.	Adenosine Triphosphate	0-3	gasdermin D	Mus musculus	165-176	
35605433-6	2022	Consistent with reduced generation of GSDMD-NT, ATP or nigericin-induced pyroptosis was markedly suppressed by DMF.	Adenosine Triphosphate	48-51	gasdermin D	Mus musculus	38-43	
35508474-11	2022	Then, WWP1 or YTHDF1 overexpression diminished LDH activity, NLRP3 inflammasomes and caspase-1-mediated cleavage of GSDMD in LPS + ATP-induced RAW264.7 cells.	Adenosine Triphosphate	131-134	gasdermin D	Mus musculus	116-121	
31175486-1	2019	ATP acts as a canonical activator to induce NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome activation in macrophages, leading to caspase-1/gasdermin D (GSDMD)-mediated pyroptosis.	Adenosine Triphosphate	0-3	gasdermin D	Mus musculus	178-183	
31175486-4	2019	The results showed that ATP treatment induced lytic cell death morphologically resembling canonical pyroptosis in both MCC950-treated BMDMs and RAW264.7 cells, but did not cause the activation of caspase-1 (by detecting caspase-1p10 and mature interleukin-1beta) and cleavage of GSDMD.	Adenosine Triphosphate	24-27	gasdermin D	Mus musculus	279-284	
30952097-0	2019	Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway.	Adenosine Triphosphate	40-43	gasdermin D	Mus musculus	106-111	
30952097-5	2019	Our present study demonstrated that KM inhibited LPS/ATP-induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome.	Adenosine Triphosphate	53-56	gasdermin D	Mus musculus	156-161	
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Adenosine Triphosphate	62-65	gasdermin D	Mus musculus	241-252	
27385778-10	2016	These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells.	Adenosine Triphosphate	56-59	gasdermin D	Mus musculus	120-125	
27385778-10	2016	These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells.	Adenosine Triphosphate	56-59	gasdermin D	Mus musculus	266-271