PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18586884-2 2008 We showed previously that mitoK(ATP) is opened by activation of a mitochondrial PKCepsilon, designated PKCepsilon1, that is closely associated with mitoK(ATP). Adenosine Triphosphate 32-35 protein kinase C epsilon Homo sapiens 80-90 20215519-6 2010 In addition, pull-down assays revealed that luteolin binds directly to PKC(epsilon) and Src in an ATP-competitive manner. Adenosine Triphosphate 98-101 protein kinase C epsilon Homo sapiens 71-83 19118560-5 2009 MitoK(ATP) opening causes an increase in ROS production, which activates mitochondrial protein kinase C epsilon (PKCvarepsilon), which inhibits the mitochondrial permeability transition (MPT), thus decreasing cell death. Adenosine Triphosphate 6-9 protein kinase C epsilon Homo sapiens 87-111 18586884-2 2008 We showed previously that mitoK(ATP) is opened by activation of a mitochondrial PKCepsilon, designated PKCepsilon1, that is closely associated with mitoK(ATP). Adenosine Triphosphate 154-157 protein kinase C epsilon Homo sapiens 80-90 16960097-2 2006 Recently, protein kinase C epsilon (PKC epsilon) has been identified as a component of the mitoK(ATP) signaling cascade. Adenosine Triphosphate 97-100 protein kinase C epsilon Homo sapiens 10-34 17373912-3 2007 In the present study, using immunoblot analysis and GFP (green fluorescent protein)-tagged PKC, we showed that, at commonly used concentrations, these ATP-competitive inhibitors alone induced redistribution of DAG (diacylglycerol)-sensitive PKCalpha, PKCbetaII, PKCdelta and PKCepsilon, but not atypical PKCzeta, to the endomembrane or the plasma membrane. Adenosine Triphosphate 151-154 protein kinase C epsilon Homo sapiens 275-285 16960097-2 2006 Recently, protein kinase C epsilon (PKC epsilon) has been identified as a component of the mitoK(ATP) signaling cascade. Adenosine Triphosphate 97-100 protein kinase C epsilon Homo sapiens 36-47 16960097-7 2006 Addition of the PKC activators 12-phorbol 13-myristate acetate, hydrogen peroxide, and the specific PKC epsilon peptide agonist, psi epsilonRACK, each activated mitoK(ATP)-dependent K+ flux in the reconstituted system. Adenosine Triphosphate 167-170 protein kinase C epsilon Homo sapiens 16-19 16960097-7 2006 Addition of the PKC activators 12-phorbol 13-myristate acetate, hydrogen peroxide, and the specific PKC epsilon peptide agonist, psi epsilonRACK, each activated mitoK(ATP)-dependent K+ flux in the reconstituted system. Adenosine Triphosphate 167-170 protein kinase C epsilon Homo sapiens 100-111 16960097-8 2006 This effect of PKC epsilon was prevented by chelerythrine, by the specific PKC epsilon peptide antagonist, epsilonV(1-2), and by the specific mitoK(ATP) inhibitor 5-hydroxydecanoate. Adenosine Triphosphate 148-151 protein kinase C epsilon Homo sapiens 15-26 12652650-6 2003 Additionally, wortmannin inhibited the cytosol-to-membrane translocation of PKC- epsilon induced by ATP/UTP. Adenosine Triphosphate 100-103 protein kinase C epsilon Homo sapiens 76-88 16288040-4 2005 Attempts to develop selective PKCepsilon inhibitors that block activation by DAG or compete with ATP have not yet met with success, suggesting a need for new strategies. Adenosine Triphosphate 97-100 protein kinase C epsilon Homo sapiens 30-40 15358201-2 2004 An ATP sensitive inwardly rectifying potassium channel, Katp (Kir6.1), the enzyme calcium independent phospholipase A2 (iPLA2), and protein kinase C epsilon (PKCepsilon) and that these genes are involved in the cardioprotective mechanism of action of urocortin. Adenosine Triphosphate 3-6 protein kinase C epsilon Homo sapiens 158-168 14570699-11 2004 We conclude that during early repair after oxidant injury in RPTC 1) PKC-epsilon is activated and translocated to mitochondria; 2) PKC-epsilon activation decreases mitochondrial respiration, electron transport rate, and ATP production by reducing complex I-linked respiration; and 3) PKC-epsilon mediates decreases in active Na+ transport and Na+-K+-ATPase activity. Adenosine Triphosphate 220-223 protein kinase C epsilon Homo sapiens 131-142 14570699-11 2004 We conclude that during early repair after oxidant injury in RPTC 1) PKC-epsilon is activated and translocated to mitochondria; 2) PKC-epsilon activation decreases mitochondrial respiration, electron transport rate, and ATP production by reducing complex I-linked respiration; and 3) PKC-epsilon mediates decreases in active Na+ transport and Na+-K+-ATPase activity. Adenosine Triphosphate 220-223 protein kinase C epsilon Homo sapiens 131-142 12763745-1 2003 Activation of myocardial kappa-opioid receptor-protein kinase C (PKC) pathways may improve postischemic contractile function through a myofilament reduction in ATP utilization. Adenosine Triphosphate 160-163 protein kinase C epsilon Homo sapiens 65-68 12652650-7 2003 These data indicated that agonist-induced PI3K and downstream PKC- epsilon activation mediated the effect of ATP/UTP on ERK1/2 activation. Adenosine Triphosphate 109-112 protein kinase C epsilon Homo sapiens 62-74 30717648-1 2019 BACKGROUND: (-)-Balanol is an ATP-mimicking inhibitor that non-selectively targets protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA). Adenosine Triphosphate 30-33 protein kinase C epsilon Homo sapiens 101-104 11884385-2 2002 It has been reported that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y(1) receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC. Adenosine Triphosphate 26-29 protein kinase C epsilon Homo sapiens 247-250 11884385-2 2002 It has been reported that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y(1) receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC. Adenosine Triphosphate 26-29 protein kinase C epsilon Homo sapiens 312-315 30717648-5 2019 The underlying basis for this fluorine-based selectivity is not entirely comprehended and needs to be investigated further for the development of ATP mimic inhibitors specific for PKCepsilon. Adenosine Triphosphate 146-149 protein kinase C epsilon Homo sapiens 180-190 30717648-6 2019 RESULTS: Using molecular dynamics (MD) simulations assisted by homology modelling and sequence analysis, we have studied the fluorine-based selectivity in the highly similar ATP sites of novel PKC (nPKC) isozymes. Adenosine Triphosphate 174-177 protein kinase C epsilon Homo sapiens 193-196 30717648-10 2019 Fluorine conformational control in 1c can synergize with and lock down the dynamics of PKCepsilon, which optimize binding interactions with the ATP site residues of the enzyme, particularly the invariant Lys437. Adenosine Triphosphate 144-147 protein kinase C epsilon Homo sapiens 87-97 30074270-6 2018 PKCepsilon activation by overexpressing constitutively active PKCepsilon exacerbated decreases in state 3 respiration, complex I activity, ATP content, and augmented RPTC death. Adenosine Triphosphate 139-142 protein kinase C epsilon Homo sapiens 0-10 30074270-6 2018 PKCepsilon activation by overexpressing constitutively active PKCepsilon exacerbated decreases in state 3 respiration, complex I activity, ATP content, and augmented RPTC death. Adenosine Triphosphate 139-142 protein kinase C epsilon Homo sapiens 62-72 30074270-7 2018 In contrast, inhibition of PKCepsilon by overexpressing dnPKCepsilon mutant restored state 3 respiration, respiratory control ratio, complex I activity, DeltaPsim , and ATP production and content, but did not prevent decreases in F0 F1 -ATPase activity. Adenosine Triphosphate 169-172 protein kinase C epsilon Homo sapiens 27-37 30074270-9 2018 We conclude that activation of PKCepsilon mediates: (a) oxidant-induced changes in DeltaPsim , decreases in mitochondrial respiration, complex I activity, and ATP content; (b) mitochondrial fragmentation; and (c) RPTC death. Adenosine Triphosphate 159-162 protein kinase C epsilon Homo sapiens 31-41 23542175-8 2014 Finally, treatment with a PKCe ATP mimetic inhibitor, PF-5263555, recapitulates genetic loss of function experiments impairing p120ctn phosphorylation as well as compromising TNBC cell growth in vitro and in vivo. Adenosine Triphosphate 31-34 protein kinase C epsilon Homo sapiens 26-30 29341608-1 2018 (-)-Balanol is an adenosine triphosphate mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. Adenosine Triphosphate 18-40 protein kinase C epsilon Homo sapiens 79-82 29297286-1 2017 BACKGROUND: (-)-Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. Adenosine Triphosphate 30-33 protein kinase C epsilon Homo sapiens 72-75 29297286-12 2017 CONCLUSIONS: To the best our knowledge, this is the first study showing that the phenolate group is charged in balanol and its analogues binding to the ATP site of PKCepsilon. Adenosine Triphosphate 152-155 protein kinase C epsilon Homo sapiens 164-174 23328793-9 2013 Here, we present methods for assessing the role of PKC-epsilon in: 1. regulation of mitochondrial morphology and functions associated with ATP synthesis, and 2. survival of RPTC in primary culture. Adenosine Triphosphate 139-142 protein kinase C epsilon Homo sapiens 51-62 21289057-7 2011 Sustained PKC-epsilon activation resulted in decreases in state 3 respiration, electron transport rate, ATP production, ATP content, and activities of complexes I and IV and F(0)F(1)-ATPase. Adenosine Triphosphate 104-107 protein kinase C epsilon Homo sapiens 10-21 21289057-7 2011 Sustained PKC-epsilon activation resulted in decreases in state 3 respiration, electron transport rate, ATP production, ATP content, and activities of complexes I and IV and F(0)F(1)-ATPase. Adenosine Triphosphate 120-123 protein kinase C epsilon Homo sapiens 10-21