PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32661312-5	2020	Biochemical studies and the co-crystal structure of CLK1 in complex with AB1 show that the irreversible competitive inhibition of CLK1 is dependent on a Michael acceptor forming an irreversible bond with Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, thereby providing selectivity.	Adenosine Triphosphate	219-222	CDC like kinase 1	Homo sapiens	52-56	
35635953-4	2022	Potency of this series was found to be mainly dependent on the presence of an intramolecular H-bond between an ortho-methoxy group and the imide NH, that stabilizes a nearly coplanar conformation of high affinity to the ATP binding pocket(s) of Clk1/4.	Adenosine Triphosphate	220-223	CDC like kinase 1	Homo sapiens	245-251	
33668683-7	2021	Furthermore, a new binding model in the ATP pocket of Clk1 was developed based on the structure-activity relationships derived from new rigidified analogues.	Adenosine Triphosphate	40-43	CDC like kinase 1	Homo sapiens	54-58	
32661312-5	2020	Biochemical studies and the co-crystal structure of CLK1 in complex with AB1 show that the irreversible competitive inhibition of CLK1 is dependent on a Michael acceptor forming an irreversible bond with Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, thereby providing selectivity.	Adenosine Triphosphate	219-222	CDC like kinase 1	Homo sapiens	130-134	
32661312-5	2020	Biochemical studies and the co-crystal structure of CLK1 in complex with AB1 show that the irreversible competitive inhibition of CLK1 is dependent on a Michael acceptor forming an irreversible bond with Cys 215 in the ATP-binding pocket, a residue that is not present in human CLK1, thereby providing selectivity.	Adenosine Triphosphate	219-222	CDC like kinase 1	Homo sapiens	130-134	
22204331-5	2012	Most of the compounds have been proved to be EGFR/HER2 kinase inhibitors, binding at the hinge region of the ATP site and some lead compounds have been optimized against a number of different kinases, including VEGFR-2, Src, Aurora A/B, Tpl, Clk and PDE10A.	Adenosine Triphosphate	109-112	CDC like kinase 1	Homo sapiens	242-245