PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6504022-3	1984	Studies on the kinetic properties of the enzymes with thymidine and ATP as the substrates and dTTP as the inhibitor showed clear differences between TK 1 and TK 2, but a close similarity between TK 2 and TK 2N.	Adenosine Triphosphate	68-71	thymidine kinase 2	Homo sapiens	158-162	
6504022-3	1984	Studies on the kinetic properties of the enzymes with thymidine and ATP as the substrates and dTTP as the inhibitor showed clear differences between TK 1 and TK 2, but a close similarity between TK 2 and TK 2N.	Adenosine Triphosphate	68-71	thymidine kinase 2	Homo sapiens	195-199	
6504022-5	1984	With ATP as the variable substrate, all three enzymes showed positive cooperative kinetics, but TK 2 and TK 2N lost the cooperativity in the presence of dTTP.	Adenosine Triphosphate	5-8	thymidine kinase 2	Homo sapiens	96-100	
19233899-3	2009	The 3"-C-branched p-methylphenyl (compound 1) and 3-CF(3)-4-Cl-phenyl (compound 7) thiourea derivatives of beta-dThd showed competitive inhibition of TK-2 when dThd was used as the variable substrate (K(i) values, 0.40 and 0.05 microM, respectively), but uncompetitive inhibition in the presence of variable concentrations of ATP (K(i) values, 15 and 2.0 microM, respectively).	Adenosine Triphosphate	326-329	thymidine kinase 2	Homo sapiens	150-154	
31459030-6	2018	The phosphate donor adenosine triphosphate (ATP) did not bind to either dTTP-bound or dTTP-free enzymes but bound tightly to the dT- or dC-TK2 complexes with large differences in enthalpy and entropy changes, strongly suggesting an ordered binding of the substrates and different conformational states of the ATP and dT- and dC-TK2 ternary complexes.	Adenosine Triphosphate	20-42	thymidine kinase 2	Homo sapiens	139-142	
31459030-6	2018	The phosphate donor adenosine triphosphate (ATP) did not bind to either dTTP-bound or dTTP-free enzymes but bound tightly to the dT- or dC-TK2 complexes with large differences in enthalpy and entropy changes, strongly suggesting an ordered binding of the substrates and different conformational states of the ATP and dT- and dC-TK2 ternary complexes.	Adenosine Triphosphate	20-42	thymidine kinase 2	Homo sapiens	328-331	
31459030-6	2018	The phosphate donor adenosine triphosphate (ATP) did not bind to either dTTP-bound or dTTP-free enzymes but bound tightly to the dT- or dC-TK2 complexes with large differences in enthalpy and entropy changes, strongly suggesting an ordered binding of the substrates and different conformational states of the ATP and dT- and dC-TK2 ternary complexes.	Adenosine Triphosphate	44-47	thymidine kinase 2	Homo sapiens	139-142	
31459030-6	2018	The phosphate donor adenosine triphosphate (ATP) did not bind to either dTTP-bound or dTTP-free enzymes but bound tightly to the dT- or dC-TK2 complexes with large differences in enthalpy and entropy changes, strongly suggesting an ordered binding of the substrates and different conformational states of the ATP and dT- and dC-TK2 ternary complexes.	Adenosine Triphosphate	44-47	thymidine kinase 2	Homo sapiens	328-331	
20218622-5	2010	This behavior is rationalized by suggesting that the inhibitors occupy the substrate-binding site in a TK-2-ATP complex that maintains the enzyme"s active site in a closed conformation through the stabilization of a small lid domain.	Adenosine Triphosphate	108-111	thymidine kinase 2	Homo sapiens	103-107	
19233899-4	2009	These kinetic properties of compounds 1 and 7 against TK-2 could be accounted for by molecular modeling showing that two hydrogen bonds can be formed between the thiourea nitrogens of compound 7 and the oxygens of the gamma-phosphate of ATP.	Adenosine Triphosphate	237-240	thymidine kinase 2	Homo sapiens	54-58	
16305527-1	2005	Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.	Adenosine Triphosphate	245-248	thymidine kinase 2	Homo sapiens	34-38	
18459168-1	2008	Human mitochondrial thymidine kinase (TK2) is a pyrimidine deoxynucleoside kinase (dNK) that catalyzes the phosphorylation of pyrimidine deoxynucleosides to their corresponding deoxynucleoside 5"-monophosphates by gamma-phosphoryl transfer from ATP.	Adenosine Triphosphate	245-248	thymidine kinase 2	Homo sapiens	38-41	
11266658-6	2001	However, 2"-O-acyl-BVaraU was extremely poorly converted to the corresponding arabinosyl nucleoside 5"-monophosphate by TK-2 as revealed by [gamma-(32)P]phosphate transfer studies from [gamma-(32)P]ATP.	Adenosine Triphosphate	198-201	thymidine kinase 2	Homo sapiens	120-124	
14690426-9	2003	Molecular docking experiments with a modeled hTK2 three-dimensional structure accurately predicted the binding positions at the active site of the natural substrates (dThd, dCyd, and ATP) and inhibitors (dTTP and dCTP), with highly conserved orientations obtained for all ligands.	Adenosine Triphosphate	183-186	thymidine kinase 2	Homo sapiens	45-49	
1433372-8	1992	Calculations of the percent of TK activity in the presence of ATP or CTP showed that this elevation was due to increased TK1 isozyme levels.	Adenosine Triphosphate	62-65	thymidine kinase 2	Homo sapiens	31-33	
1433372-6	1992	By calculating the percent of TK activity in the presence of adenosine triphosphate (ATP) or cytidine triphosphate (CTP), we estimated the relative contributions of TK isozymes TK1 and TK2 to total TK activity.	Adenosine Triphosphate	61-83	thymidine kinase 2	Homo sapiens	30-32	
1433372-10	1992	ER- patients with recurrence had significantly (P < .001) elevated total tumor TK levels compared with levels in those who did not have recurrence, and calculation of percent of TK activity with ATP or CTP indicated elevated TK1 levels.	Adenosine Triphosphate	198-201	thymidine kinase 2	Homo sapiens	181-183	
1433372-6	1992	By calculating the percent of TK activity in the presence of adenosine triphosphate (ATP) or cytidine triphosphate (CTP), we estimated the relative contributions of TK isozymes TK1 and TK2 to total TK activity.	Adenosine Triphosphate	85-88	thymidine kinase 2	Homo sapiens	30-32	
34758700-0	2022	Mutational analyses of human thymidine kinase 2 reveal key residues in ATP-Mg2+ binding and catalysis.	Adenosine Triphosphate	71-74	thymidine kinase 2	Homo sapiens	29-47	
34758700-4	2022	We showed that mutations of Gln-110 and Glu-133 affected Mg2+ and ATP binding, and thus are crucial for TK2 function.	Adenosine Triphosphate	66-69	thymidine kinase 2	Homo sapiens	104-107