PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9685673-2 1998 Ibogaine and noribogaine were shown to have affinity for the serotonin transporter, and inhibition of serotonin reuptake has been proposed to be involved in their anti-addictive actions. Ibogaine 0-8 solute carrier family 6 member 4 Rattus norvegicus 61-82 10911925-11 2000 Ibogaine and its metabolite noribogaine have low microM affinities for kappa and mu opioid receptors, NMDA receptors, 5HT-3 receptors, sigma-2 sites, sodium channels and the serotonin transporter. Ibogaine 0-8 solute carrier family 6 member 4 Rattus norvegicus 174-195 9685673-9 1998 These and other data suggest that (1) the serotonergic system may not be an essential factor in the anti-addictive actions of these drugs; (2) ibogaine (or an unidentified metabolite) may release serotonin as well as inhibit its reuptake; (3) stimulation of the ascending serotonergic system may mediate ibogaine"s hallucinogenic effect; and (4) 18-MC probably has no affinity for the serotonin transporter, and is unlikely to be a hallucinogen. Ibogaine 143-151 solute carrier family 6 member 4 Rattus norvegicus 385-406 27140629-5 2016 Using membranes from HeLa cells expressing SERT and intact rat basophilic leukemia cells, we show that agents such as Na(+) and cocaine that stabilize outward-open conformations of SERT decreased phosphorylation and agents that stabilize inward-open conformations (e.g., 5-HT, ibogaine) increased phosphorylation. Ibogaine 277-285 solute carrier family 6 member 4 Rattus norvegicus 181-185 8880938-5 1996 Both ibogaine and 12-OH ibogamine demonstrated the highest potency values at the cocaine recognition site on the 5-HT transporter. Ibogaine 5-13 solute carrier family 6 member 4 Rattus norvegicus 113-129