PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9476990-0 1998 Behavioral and biochemical evidence for a nonessential 5-HT2A component of the ibogaine-induced discriminative stimulus. Ibogaine 79-87 5-hydroxytryptamine receptor 2A Rattus norvegicus 55-61 9476990-3 1998 This intermediate generalization was completely blocked by pretreatment with the 5-HT2A antagonist pirenpirone, suggesting that the ibogaine-like effects of these agents are mediated by the 5-HT2A receptor. Ibogaine 132-140 5-hydroxytryptamine receptor 2A Rattus norvegicus 81-87 9476990-3 1998 This intermediate generalization was completely blocked by pretreatment with the 5-HT2A antagonist pirenpirone, suggesting that the ibogaine-like effects of these agents are mediated by the 5-HT2A receptor. Ibogaine 132-140 5-hydroxytryptamine receptor 2A Rattus norvegicus 190-196 9476990-6 1998 Micromolar 5-HT2A affinity was observed with ibogaine (92.5 microM), 12-hydroxyibogamine (34.5 microM), and harmaline (42.5 microM). Ibogaine 45-53 5-hydroxytryptamine receptor 2A Rattus norvegicus 11-17 9476990-8 1998 The results of these studies suggest that although ibogaine may produce some of its effects via interactions with 5-HT2A receptors, these do not appear to be essential to the ibogaine-induced discriminative stimulus. Ibogaine 51-59 5-hydroxytryptamine receptor 2A Rattus norvegicus 114-120