PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26807959-17	2016	CARDIOTOXICITY: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine"s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by ibogaine delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.	Ibogaine	111-119	ETS transcription factor ERG	Homo sapiens	44-48	
26807959-17	2016	CARDIOTOXICITY: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine"s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by ibogaine delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.	Ibogaine	111-119	ETS transcription factor ERG	Homo sapiens	141-145	
26807959-17	2016	CARDIOTOXICITY: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine"s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by ibogaine delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.	Ibogaine	238-246	ETS transcription factor ERG	Homo sapiens	44-48	
26807959-17	2016	CARDIOTOXICITY: Ether-a-go-go-related gene (hERG) potassium channels in the heart might play a crucial role in ibogaine"s cardiotoxicity, as hERG channels are vital in the repolarization phase of cardiac action potentials and blockade by ibogaine delays this repolarization, resulting in QT (time interval between the start of the Q wave and the end of the T wave in the electrical cycle of the heart) interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.	Ibogaine	238-246	ETS transcription factor ERG	Homo sapiens	141-145	
22458604-0	2014	Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.	Ibogaine	20-28	ETS transcription factor ERG	Homo sapiens	38-42	
24307198-0	2014	Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.	Ibogaine	68-76	ETS transcription factor ERG	Homo sapiens	13-17	
24307198-3	2014	Therefore, we studied in detail the interaction of ibogaine with hERG channels heterologously expressed in mammalian kidney tsA-201 cells.	Ibogaine	51-59	ETS transcription factor ERG	Homo sapiens	65-69	
24307198-4	2014	Currents through hERG channels were blocked regardless of whether ibogaine was applied via the extracellular or intracellular solution.	Ibogaine	66-74	ETS transcription factor ERG	Homo sapiens	17-21	
24307198-10	2014	Mutations in the binding site reported for other hERG channel blockers (Y652A and F656A) reduced the potency of ibogaine, whereas an inactivation-deficient double mutant (G628C/S631C) was as sensitive as wild-type channels.	Ibogaine	112-120	ETS transcription factor ERG	Homo sapiens	49-53	
24307198-12	2014	Experimental current traces were fit to a kinetic model of hERG channel gating, revealing preferential binding of ibogaine to the open and inactivated state.	Ibogaine	114-122	ETS transcription factor ERG	Homo sapiens	59-63	
24307198-13	2014	Taken together, these findings show that ibogaine blocks hERG channels from the cytosolic side either in its charged form alone or in company with its uncharged form and alters the currents by changing the relative contribution of channel states over time.	Ibogaine	41-49	ETS transcription factor ERG	Homo sapiens	57-61	
23707769-3	2013	We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets.	Ibogaine	31-39	ETS transcription factor ERG	Homo sapiens	55-58	
23707769-3	2013	We have recently reported that ibogaine inhibits human ERG (hERG) potassium channels at concentrations similar to the drugs affinity for several of its known brain targets.	Ibogaine	31-39	ETS transcription factor ERG	Homo sapiens	60-64	
23707769-6	2013	We confirmed that heterologously expressed hERG currents are reduced by ibogaine in low micromolar concentrations.	Ibogaine	72-80	ETS transcription factor ERG	Homo sapiens	43-47