PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34971743-0 2022 LincRNA-p21 promotes p21-mediated cell cycle arrest in benzene-induced hematotoxicity by sponging miRNA-17-5p. Benzene 55-62 tumor protein p53 pathway corepressor 1 Homo sapiens 0-11 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. Benzene 70-77 tumor protein p53 pathway corepressor 1 Homo sapiens 49-60 34971743-7 2022 Upon exploring the underlying mechanism by which lincRNA-p21 mediates benzene-induced hematotoxicity, we observed that the negative regulation of 1,4-benzoquinone (1,4-BQ) on cell cycle arrest and inhibition of K562 cell proliferation was partially relieved by lincRNA-p21 knockdown, which can inhibit the expression of P21 and thereby suppress the toxic effects of 1,4-BQ. Benzene 70-77 tumor protein p53 pathway corepressor 1 Homo sapiens 261-272 34971743-9 2022 In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA-17-5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity. Benzene 43-50 tumor protein p53 pathway corepressor 1 Homo sapiens 82-93 34971743-9 2022 In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA-17-5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity. Benzene 43-50 tumor protein p53 pathway corepressor 1 Homo sapiens 174-185 34971743-9 2022 In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA-17-5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity. Benzene 189-196 tumor protein p53 pathway corepressor 1 Homo sapiens 82-93 34971743-9 2022 In conclusion, our research suggested that benzene induces hematotoxicity via the lincRNA-p21/miRNA-17-5p/p21 signaling which might contribute to the underlying mechanism of lincRNA-p21 in benzene-induced hematotoxicity. Benzene 189-196 tumor protein p53 pathway corepressor 1 Homo sapiens 174-185 34971743-10 2022 Therefore, lincRNA-p21 can serve as a potential biomarker for the early detection of hematopoiesis inhibition in individuals with long-term exposure to low-dose benzene. Benzene 161-168 tumor protein p53 pathway corepressor 1 Homo sapiens 11-22