PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20018183-3	2010	Concerning the incidence of AMLs, though a dose of 300 ppm benzene inhalation induced 9% AMLs in wild-type C3H/He mice-AML-prone, it induced AMLs in 38% of Trp53-deficient C3H/He mice.	Benzene	59-66	transformation related protein 53	Mus musculus	156-161	
20018183-4	2010	Because AMLs were also observed in Trp53-deficient mice, including in the C57BL/6 mice, benzene exposure may also be a potent inducer of AMLs in mice with some strain differences.	Benzene	88-95	transformation related protein 53	Mus musculus	35-40	
19478238-0	2009	Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice.	Benzene	0-7	transformation related protein 53	Mus musculus	70-75	
19478238-7	2009	To determine whether Trp53 deficiency satisfies the above hypotheses by eliminating or reducing DNA repair and by allowing cells to escape apoptosis, we evaluated the incidence of benzene-induced HPNs in Trp53-deficient C57BL/6 mice with specific regard to AMLs.	Benzene	180-187	transformation related protein 53	Mus musculus	204-209	
19478238-9	2009	As a result, heterozygous Trp53-deficient mice of both strains showed a nonthreshold response of the incidence of HPNs at the lower dose, whereas both strains showed an increasing HPN incidence up to 100% with increasing benzene exposure dose, including AMLs, that developed 38% of heterozygous Trp53-deficient C3H/He mice compared to only 9% of wild-type mice exposed to the high dose.	Benzene	221-228	transformation related protein 53	Mus musculus	26-31	
19478238-9	2009	As a result, heterozygous Trp53-deficient mice of both strains showed a nonthreshold response of the incidence of HPNs at the lower dose, whereas both strains showed an increasing HPN incidence up to 100% with increasing benzene exposure dose, including AMLs, that developed 38% of heterozygous Trp53-deficient C3H/He mice compared to only 9% of wild-type mice exposed to the high dose.	Benzene	221-228	transformation related protein 53	Mus musculus	295-300	
19478238-10	2009	The detection of AMLs in heterozygous Trp53-deficient mice, even in the C57BL/6 strain, implies that benzene may be a potent inducer of AMLs also in mice with some strain differences.	Benzene	101-108	transformation related protein 53	Mus musculus	38-43	
11896287-0	2002	p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene.	Benzene	108-115	transformation related protein 53	Mus musculus	0-3	
11896287-0	2002	p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzene.	Benzene	108-115	transformation related protein 53	Mus musculus	49-52	
11159747-6	2001	Benzene induced p53 LOH in 13 of 16 tumors examined.	Benzene	0-7	transformation related protein 53	Mus musculus	16-19	
10850423-0	2000	Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination.	Benzene	15-22	transformation related protein 53	Mus musculus	8-11	
10850423-0	2000	Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination.	Benzene	15-22	transformation related protein 53	Mus musculus	51-54	
10850423-1	2000	The purpose of this study was to examine the role of chromosomal recombination in mediating p53 loss in benzene-induced thymic lymphomas in C57BL/6-Trp53 haploinsufficient (N5) mice (p53+/- mice).	Benzene	104-111	transformation related protein 53	Mus musculus	92-95	
10850423-1	2000	The purpose of this study was to examine the role of chromosomal recombination in mediating p53 loss in benzene-induced thymic lymphomas in C57BL/6-Trp53 haploinsufficient (N5) mice (p53+/- mice).	Benzene	104-111	transformation related protein 53	Mus musculus	150-153	
10850423-4	2000	Nearly 90% (24 of 27) of benzene-induced tumors exhibited loss of the functional p53 allele locus, and 83% (20 of 24) of these tumors retained two copies of the disrupted p53 allele.	Benzene	25-32	transformation related protein 53	Mus musculus	81-84	
10850423-4	2000	Nearly 90% (24 of 27) of benzene-induced tumors exhibited loss of the functional p53 allele locus, and 83% (20 of 24) of these tumors retained two copies of the disrupted p53 allele.	Benzene	25-32	transformation related protein 53	Mus musculus	171-174	
10850423-5	2000	The results indicate that benzene induces a high frequency of LOH on chromosome 11 in p53+/- mice, likely mediated by aberrant chromosomal recombination.	Benzene	26-33	transformation related protein 53	Mus musculus	86-89