PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33671323-6	2021	The carbamazepine-10,11-epoxide model applies metabolism by epoxide hydroxylase 1 (EPHX1) and glomerular filtration.	10,11-epoxide	18-31	epoxide hydrolase 1	Homo sapiens	60-81	
33217013-11	2021	EPHX1-416G/G genotype was a significant covariate for the clearance of carbamazepine 10,11-epoxide.	10,11-epoxide	85-98	epoxide hydrolase 1	Homo sapiens	0-5	
33217013-12	2021	CONCLUSION: Our data indicate that carbamazepine clearance was affected by total dose and phenytoin co-administration, but not by genetic factors, while carbamazepine 10,11-epoxide clearance was affected by a variant in the microsomal epoxide hydrolase gene.	10,11-epoxide	167-180	epoxide hydrolase 1	Homo sapiens	224-252	
33671323-6	2021	The carbamazepine-10,11-epoxide model applies metabolism by epoxide hydroxylase 1 (EPHX1) and glomerular filtration.	10,11-epoxide	18-31	epoxide hydrolase 1	Homo sapiens	83-88	
24817818-1	2014	BACKGROUND: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CBZ) 10,11-epoxide (the active metabolite of CBZ) by evaluating the variation in serum CBZ 10,11-epoxide levels 4 hours after administration of the drug.	10,11-epoxide	238-251	epoxide hydrolase 1	Homo sapiens	142-147