PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18082333-7 2008 In addition, we found that chronic lithium treatment inhibited reactive oxygen metabolite H(2)O(2)-induced cell death and DNA fragmentation in primary cultured rat cerebral cortical cells, while GST inhibitor ethacrynic acid reduced the neuroprotective effect of lithium against H(2)O(2)-induced cell death and DNA fragmentation. Ethacrynic Acid 209-224 hematopoietic prostaglandin D synthase Rattus norvegicus 195-198 22065940-3 2011 The main objective of the present study was to examine the effect of GST inhibition (with the administration of ethacrynic acid [EA]) on the viability and apoptosis of cardiomyocytes when these cells are exposed to various stress components of I/R and mitogen-activated protein kinase (c-Jun N-terminal kinase, p38 and extracellular signal-regulated kinase [ERK]) inhibitors. Ethacrynic Acid 112-127 hematopoietic prostaglandin D synthase Rattus norvegicus 69-72 22065940-3 2011 The main objective of the present study was to examine the effect of GST inhibition (with the administration of ethacrynic acid [EA]) on the viability and apoptosis of cardiomyocytes when these cells are exposed to various stress components of I/R and mitogen-activated protein kinase (c-Jun N-terminal kinase, p38 and extracellular signal-regulated kinase [ERK]) inhibitors. Ethacrynic Acid 129-131 hematopoietic prostaglandin D synthase Rattus norvegicus 69-72 11738622-7 2002 The compounds were conjugated to the model electrophile ethacrynic acid (EA) to resemble GS-EA, an efficient GST inhibitor. Ethacrynic Acid 56-71 hematopoietic prostaglandin D synthase Rattus norvegicus 109-112 12449241-5 2002 16 hr prior to sacrifice, significant decreases were observed in EROD and GST activities toward CDNB, EAA, EPNP, and CHPx, and GSH level. Ethacrynic Acid 102-105 hematopoietic prostaglandin D synthase Rattus norvegicus 74-77 11738622-7 2002 The compounds were conjugated to the model electrophile ethacrynic acid (EA) to resemble GS-EA, an efficient GST inhibitor. Ethacrynic Acid 73-75 hematopoietic prostaglandin D synthase Rattus norvegicus 109-112 9580876-7 1998 The activity of glutathione-S-transferase with ethacrynic acid and cross-reactivity with rat subunit 7 was lower in all experimental groups in the kidney and liver, except in the liver of the group given a higher dose of ANITEN I. Ethacrynic Acid 47-62 hematopoietic prostaglandin D synthase Rattus norvegicus 16-41 11668494-4 2001 When the cells were treated with 100 microM ethacrynic acid (ECA), an inhibitor of GST, DNA fragmentation and caspase-3 activation were observed. Ethacrynic Acid 44-59 hematopoietic prostaglandin D synthase Rattus norvegicus 83-86 11668494-4 2001 When the cells were treated with 100 microM ethacrynic acid (ECA), an inhibitor of GST, DNA fragmentation and caspase-3 activation were observed. Ethacrynic Acid 61-64 hematopoietic prostaglandin D synthase Rattus norvegicus 83-86 9021168-2 1996 When the male adult rats (225-275 g) were treated with 10% EtOH (v/v) in their drinking for 21 days AH, AMND and EROD activities and LP and GSH levels increased significantly whereas GST activity for EAA decreased significantly in liver as compared to controls. Ethacrynic Acid 200-203 hematopoietic prostaglandin D synthase Rattus norvegicus 183-186 8960251-4 1995 The activity of cytosol glutathione S-transferase (GST) was decreased to 55% of the control with p-nitrobenzyl chloride, and was unchanged with 1-chloro-2,4-dinitrobenzene, and ethacrynic acid. Ethacrynic Acid 177-192 hematopoietic prostaglandin D synthase Rattus norvegicus 51-54 1494888-2 1992 Ethacrynic acid (EA), a phenoxyacetic acid diuretic, has similar effects to tienilic acid (TA) on rat liver glutathione S-transferase (GST) activity in vitro, using either 1-chloro-2,4-dinitrobenzene or sulphobromophthalein (BSP) as a substrate. Ethacrynic Acid 0-15 hematopoietic prostaglandin D synthase Rattus norvegicus 108-133 1494888-2 1992 Ethacrynic acid (EA), a phenoxyacetic acid diuretic, has similar effects to tienilic acid (TA) on rat liver glutathione S-transferase (GST) activity in vitro, using either 1-chloro-2,4-dinitrobenzene or sulphobromophthalein (BSP) as a substrate. Ethacrynic Acid 0-15 hematopoietic prostaglandin D synthase Rattus norvegicus 135-138 1494888-2 1992 Ethacrynic acid (EA), a phenoxyacetic acid diuretic, has similar effects to tienilic acid (TA) on rat liver glutathione S-transferase (GST) activity in vitro, using either 1-chloro-2,4-dinitrobenzene or sulphobromophthalein (BSP) as a substrate. Ethacrynic Acid 17-19 hematopoietic prostaglandin D synthase Rattus norvegicus 135-138 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Ethacrynic Acid 214-229 hematopoietic prostaglandin D synthase Rattus norvegicus 74-99 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Ethacrynic Acid 214-229 hematopoietic prostaglandin D synthase Rattus norvegicus 101-104 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Ethacrynic Acid 231-234 hematopoietic prostaglandin D synthase Rattus norvegicus 74-99 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Ethacrynic Acid 231-234 hematopoietic prostaglandin D synthase Rattus norvegicus 101-104 2612064-5 1989 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Ethacrynic Acid 194-209 hematopoietic prostaglandin D synthase Rattus norvegicus 8-33 2612064-5 1989 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Ethacrynic Acid 211-213 hematopoietic prostaglandin D synthase Rattus norvegicus 8-33 3355583-3 1988 Hepatic cytosolic glutathione S-transferase (GST) activity was determined with the substrates 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, ethacrynic acid and trans-4-phenyl-3-buten-2-one. Ethacrynic Acid 152-167 hematopoietic prostaglandin D synthase Rattus norvegicus 18-43 3355583-3 1988 Hepatic cytosolic glutathione S-transferase (GST) activity was determined with the substrates 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, ethacrynic acid and trans-4-phenyl-3-buten-2-one. Ethacrynic Acid 152-167 hematopoietic prostaglandin D synthase Rattus norvegicus 45-48 3355583-5 1988 GST activity toward 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene and ethacrynic acid was enhanced by all compounds, hexachlorobenzene and 3-methylcholanthrene causing the largest and the smallest increase respectively. Ethacrynic Acid 81-96 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 3335840-3 1988 Furthermore, when C6 glioma cells were exposed to a culture medium supplemented with specific glutathione S-transferase inhibitors, ethacrynic acid and caffeic acid, cell growth was remarkably suppressed. Ethacrynic Acid 132-147 hematopoietic prostaglandin D synthase Rattus norvegicus 94-119 26045187-1 2015 AIMS: We studied the effects of the inhibition of the endogene antioxidant glutathione-S-transferase (GST) by ethacrynic acid (EA) on ischemia-reperfusion (IR) injury and postconditioning (PC) in the lower extremities. Ethacrynic Acid 110-125 hematopoietic prostaglandin D synthase Rattus norvegicus 75-100 26045187-1 2015 AIMS: We studied the effects of the inhibition of the endogene antioxidant glutathione-S-transferase (GST) by ethacrynic acid (EA) on ischemia-reperfusion (IR) injury and postconditioning (PC) in the lower extremities. Ethacrynic Acid 110-125 hematopoietic prostaglandin D synthase Rattus norvegicus 102-105 26045187-1 2015 AIMS: We studied the effects of the inhibition of the endogene antioxidant glutathione-S-transferase (GST) by ethacrynic acid (EA) on ischemia-reperfusion (IR) injury and postconditioning (PC) in the lower extremities. Ethacrynic Acid 127-129 hematopoietic prostaglandin D synthase Rattus norvegicus 75-100 26045187-1 2015 AIMS: We studied the effects of the inhibition of the endogene antioxidant glutathione-S-transferase (GST) by ethacrynic acid (EA) on ischemia-reperfusion (IR) injury and postconditioning (PC) in the lower extremities. Ethacrynic Acid 127-129 hematopoietic prostaglandin D synthase Rattus norvegicus 102-105