PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16499573-10 2006 We also observed that throughout C. trachomatis persistence induced by doxycycline (Dox) treatment, IL-1beta, IL-6, IL-8 and TNF-alpha expression was reduced, whereas the synthesis of IL-10 and IL-12p70 remained unchanged but not sustained. Doxycycline 84-87 interleukin 6 Homo sapiens 110-114 21073054-9 2010 The levels of IL-6 and Wolbachia DNA in the plasma were significantly lower in the doxycycline group. Doxycycline 83-94 interleukin 6 Homo sapiens 14-18 21461372-3 2011 In this study, we evaluated the effectiveness of doxycycline and tetracycline to modulate serum levels of IL-6, IL-1B, and TNF and cytokine receptor/receptor antagonist TNF-R1 and IL-1RA in patients with DF or DHF. Doxycycline 49-60 interleukin 6 Homo sapiens 106-110 21182500-16 2011 Increased expression of IL-6 in PP skin lesions may explain the effects of doxycycline in terms of its anti-inflammatory properties. Doxycycline 75-86 interleukin 6 Homo sapiens 24-28 18771379-7 2008 RESULTS: The secretion of IL-1beta and -8 and TNF-alpha by macrophages decreased significantly (P <0.05) when they were pretreated with 2 microM doxycycline, whereas a concentration of 10 microM was required to significantly reduce IL-6 secretion. Doxycycline 148-159 interleukin 6 Homo sapiens 235-239 17713325-0 2007 Effects of levofloxacin and doxycycline on interleukin-6 production of Chlamydia trachomatis-infected human synovial fibroblasts. Doxycycline 28-39 interleukin 6 Homo sapiens 43-56 17713325-6 2007 RESULTS: The production of IL-6 was suppressed to as low as 1,800 pg/ml in the infected HFLS treated with levofloxacin or doxycycline immediately or early after infection. Doxycycline 122-133 interleukin 6 Homo sapiens 27-31 17713325-7 2007 In HFLS treated with levofloxacin and doxycycline, the IL-6 levels decreased to 37,000 and 21,000 pg/ml, respectively, 48 h after infection, and levofloxacin was thus found to be less effective than doxycycline. Doxycycline 38-49 interleukin 6 Homo sapiens 55-59 14687223-1 2004 OBJECTIVE: To investigate whether sub-antimicrobial dose doxycycline (SDD) therapy for 120 d in chronic adult periodontitis patients had significant effects on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels, and on gingival tissue MMP-9, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) and interleukin-6 (IL-6) levels. Doxycycline 57-68 interleukin 6 Homo sapiens 326-339 14687223-1 2004 OBJECTIVE: To investigate whether sub-antimicrobial dose doxycycline (SDD) therapy for 120 d in chronic adult periodontitis patients had significant effects on gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) levels, and on gingival tissue MMP-9, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) and interleukin-6 (IL-6) levels. Doxycycline 57-68 interleukin 6 Homo sapiens 341-345 11327259-6 2001 In addition, treatment with 10 microg/ml doxycycline resulted in 2.2-fold upregulation of transforming growth factor (TGF-beta3) and a significant decrease of interleukin 1alpha (IL-1alpha), IL-1beta, and IL-6 mRNA. Doxycycline 41-52 interleukin 6 Homo sapiens 205-209 12052568-9 2002 In conclusion, the levels of the well known proinflammatory cytokines TNF-alpha, IL-1beta and IL-6 increased in the V. vulnificus septicemic patients" sera, and the levels of TNF-alpha and IL-1beta decreased significantly after doxycycline treatment. Doxycycline 228-239 interleukin 6 Homo sapiens 94-98 10996844-4 2000 Removal of doxycycline from the culture medium elevated gp130 expression and increased the responsiveness of a STAT-responsive promoter-luciferase construct to IL-6 complexed with its soluble receptor (IL-6+sIL-6R), but diminished the responsiveness to oncostatin M (OSM). Doxycycline 11-22 interleukin 6 Homo sapiens 160-164 10996844-4 2000 Removal of doxycycline from the culture medium elevated gp130 expression and increased the responsiveness of a STAT-responsive promoter-luciferase construct to IL-6 complexed with its soluble receptor (IL-6+sIL-6R), but diminished the responsiveness to oncostatin M (OSM). Doxycycline 11-22 interleukin 6 Homo sapiens 202-206 34988139-10 2021 In addition, SGDL granule + doxycycline effectively inhibited IBV replication and stopped IBV propagation from the trachea to the lung; modulated the mRNA expressions of IL-1beta, IL-6, TNF-alpha, and IFN-gamma; and extenuated the histopathology lesions in trachea and lung. Doxycycline 28-39 interleukin 6 Homo sapiens 180-184 25977597-3 2015 In this study, we wanted to assess the efficacy of both low and high doxycycline doses in modulating IL-8, TNF-alpha, and IL-6 gene expression in HaCaT cells stimulated with LPS. Doxycycline 69-80 interleukin 6 Homo sapiens 122-126 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Doxycycline 87-98 interleukin 6 Homo sapiens 176-189 32905367-2 2020 The present study aimed to explore the clinical efficacy of azithromycin combined with doxycycline in patients with NGU and its effect on serum levels of inflammatory cytokine interleukin-6 (IL-6). Doxycycline 87-98 interleukin 6 Homo sapiens 191-195 32314492-0 2020 Doxycycline, a widely used antibiotic in dermatology with a possible anti-inflammatory action against IL-6 in COVID-19 outbreak. Doxycycline 0-11 interleukin 6 Homo sapiens 102-106 28178994-16 2017 Treatment of breast cancer cells with doxycycline also decreased the translocation of NF-kappaB to the nucleus and the mRNA levels for IL-6 in the presence or absence of lysophosphatidate. Doxycycline 38-49 interleukin 6 Homo sapiens 135-139 31327083-8 2020 DOXY group exhibited a significant increase in the levels of anti-inflammatory interleukin (IL)-10 and a reduction in IL-8, IFN-y, IL-6, and IL-17 (p < 0.05), significant reduction in periodontal pathogens (p < 0.05), and a lower mean percentage of HbA1C at 3 months (p < 0.05). Doxycycline 0-4 interleukin 6 Homo sapiens 131-135 28242843-11 2017 Furthermore, human peripheral monocytes incubated with HepAD38 (dox-)-exo induced a significantly lower level of IL-6 secretion compared with IL-6 levels from HepAD38 (dox+)-exo. Doxycycline 64-67 interleukin 6 Homo sapiens 113-117 28242843-11 2017 Furthermore, human peripheral monocytes incubated with HepAD38 (dox-)-exo induced a significantly lower level of IL-6 secretion compared with IL-6 levels from HepAD38 (dox+)-exo. Doxycycline 168-171 interleukin 6 Homo sapiens 142-146 28242843-12 2017 Irreversible inhibition of proteasomal activity within exosomes restored higher production of IL-6 by monocytes, suggesting that transmission of proteasome subunit proteins by HepAD38 (dox-)-exo might modulate the production of pro-inflammatory molecules in the recipient monocytes. Doxycycline 185-188 interleukin 6 Homo sapiens 94-98 28178994-11 2017 RESULTS: Doxycycline decreased plasma lysophosphatidate concentrations, delayed tumor growth and decreased the concentrations of several cytokines/chemokines (IL-1beta, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor. Doxycycline 9-20 interleukin 6 Homo sapiens 169-173 25858261-0 2015 Dengue Patients Treated with Doxycycline Showed Lower Mortality Associated to a Reduction in IL-6 and TNF Levels. Doxycycline 29-40 interleukin 6 Homo sapiens 93-97 25858261-6 2015 Moreover, administration of doxycycline resulted in a significant (p<0.01) decrease in levels of TNF and IL-6 versus controls in the tests performed during follow-up (day 3, 5 and 7). Doxycycline 28-39 interleukin 6 Homo sapiens 108-112 21771657-3 2011 In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively. Doxycycline 44-55 interleukin 6 Homo sapiens 175-179 21848430-9 2012 However, in presence of doxycycline, inhibition of cytokines (IL-1beta and IL-6) was only observed in stimulated cells from fertile women with primary C. trachomatis infection. Doxycycline 24-35 interleukin 6 Homo sapiens 75-79 25159306-0 2014 Antioxidant response of osteoblasts to doxycycline in an inflammatory model induced by C-reactive protein and interleukin-6. Doxycycline 39-50 interleukin 6 Homo sapiens 110-123 21771657-6 2011 In other studies, a non-antimicrobial formulation of doxycycline (SDD) has been found to dramatically reduce hsCRP, IL-6 and MMP-9 levels in plasma of ACS patients, and SDD has also been found to significantly increase serum levels of both cardio-protective HDL cholesterol and its core molecule apolipoprotein A-I in ASCVD-vulnerable patients with periodontitis. Doxycycline 53-64 interleukin 6 Homo sapiens 116-120