PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27404728-1 2016 Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. Selenium 80-88 selenium binding protein 1 Homo sapiens 0-26 16380993-5 2006 Selenium can disrupt the androgen pathway, which has been implicated in modulating SELENBP1 expression. Selenium 0-8 selenium binding protein 1 Homo sapiens 83-91 16380993-7 2006 Interestingly, SELENBP1 mRNA and protein levels were reduced by androgen and elevated by selenium treatment in the normal HOSE cells, whereas reversed responses were observed in the ovarian cancer cell lines. Selenium 89-97 selenium binding protein 1 Homo sapiens 15-23 16380993-8 2006 These results suggest that changes of SELENBP1 expression in malignant ovarian cancer are an indicator of aberration of selenium/androgen pathways and may reveal prognostic information of ovarian cancer. Selenium 120-128 selenium binding protein 1 Homo sapiens 38-46 32689184-1 2005 In the Arabidopsis genome there are three highly conserved homologues of the mammalian 56-kD selenium-binding protein (SBP). Selenium 93-101 selenium binding protein 1 Homo sapiens 119-122 9926907-8 1998 African-American and lower SES youth exhibited higher SBP and DBP values than whites and higher SES youth. Selenium 27-30 selenium binding protein 1 Homo sapiens 54-57 9679983-6 1998 hSP56 expression was especially high in normal tissues that appear to benefit from the cancer-protective action of dietary selenium and was low in many neoplastic cells. Selenium 123-131 selenium binding protein 1 Homo sapiens 0-5 34140879-11 2021 The tight correlation of SELENBP1 with CCL2 levels provides a novel link between Se metabolism and immune cell activation, with potential relevance for neurological damage and regeneration processes, respectively. Selenium 81-83 selenium binding protein 1 Homo sapiens 25-33 3757145-7 1986 DNA damage was also induced in HSBP cells following treatment with selenium but only in the presence of reduced glutathione. Selenium 67-75 selenium binding protein 1 Homo sapiens 31-35 31557719-1 2020 Human selenium-binding protein 1 (SELENBP1) was originally identified as a protein binding selenium, most likely as selenite. Selenium 6-14 selenium binding protein 1 Homo sapiens 34-42 30732890-2 2019 As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. Selenium 7-15 selenium binding protein 1 Homo sapiens 90-98 30732890-2 2019 As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. Selenium 17-19 selenium binding protein 1 Homo sapiens 90-98 30732890-2 2019 As the selenium (Se) status is affected by inflammation and hypoxia, we hypothesized that SELENBP1 contributes to disease-specific Se metabolism. Selenium 131-133 selenium binding protein 1 Homo sapiens 90-98 30732890-10 2019 CONCLUSIONS: Until now, SELENBP1 was mainly considered as an intracellular protein involved in Se metabolism and redox control. Selenium 95-97 selenium binding protein 1 Homo sapiens 24-32 30400135-1 2018 Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. Selenium 86-94 selenium binding protein 1 Homo sapiens 0-26 30400135-1 2018 Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. Selenium 86-94 selenium binding protein 1 Homo sapiens 28-32 27477809-2 2016 Selenium-binding protein 1 (SBP1) has been shown as a possible mediator of selenium"s anti-cancer functions. Selenium 75-83 selenium binding protein 1 Homo sapiens 0-26 27477809-2 2016 Selenium-binding protein 1 (SBP1) has been shown as a possible mediator of selenium"s anti-cancer functions. Selenium 75-83 selenium binding protein 1 Homo sapiens 28-32 27404728-1 2016 Selenium-binding protein 1 (SBP1) is not a selenoprotein but structurally binds selenium. Selenium 80-88 selenium binding protein 1 Homo sapiens 28-32 27404728-3 2016 Because genome instability is a hallmark of cancer, we hypothesize that SBP1 sequesters cellular selenium and sensitizes cancer cells to DNA-damaging agents. Selenium 97-105 selenium binding protein 1 Homo sapiens 72-76 27404728-5 2016 Reduced sensitivity to hydrogen peroxide, paraquat and camptothecin, reactive oxygen species content, and intracellular retention of selenium after selenomethionine treatment were observed in SBP1 shRNA HeLa cells. Selenium 133-141 selenium binding protein 1 Homo sapiens 192-196 27404728-8 2016 Altogether, SBP1 retains supplemental selenium and sensitizes HeLa cancer cells to clastogens, suggesting a new cancer treatment strategy by sequestering selenium through SBP1. Selenium 38-46 selenium binding protein 1 Homo sapiens 12-16 27404728-8 2016 Altogether, SBP1 retains supplemental selenium and sensitizes HeLa cancer cells to clastogens, suggesting a new cancer treatment strategy by sequestering selenium through SBP1. Selenium 154-162 selenium binding protein 1 Homo sapiens 12-16 26593911-2 2015 SBP1 binds tightly selenium although what role selenium plays in its biological functions remains unknown. Selenium 19-27 selenium binding protein 1 Homo sapiens 0-4 24163737-2 2013 Selenium-binding protein 1 (SBP1) is a member of an unusual class of selenium-containing proteins that may function as a tumor suppressor in multiple cancer types and whose levels have been shown to be lower in cancers as compared to corresponding normal tissues. Selenium 69-77 selenium binding protein 1 Homo sapiens 0-26 25227434-1 2014 BACKGROUND: The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. Selenium 38-46 selenium binding protein 1 Homo sapiens 101-109 24395536-6 2014 The relationship between SBP1 and GPx-1 represents a unique example of a molecular interaction between selenium containing proteins with a likely significant impact on human health and disease. Selenium 103-111 selenium binding protein 1 Homo sapiens 25-29 25445402-3 2015 This study was to investigate the roles of two distinct representatives of selenium-containing proteins, selenium-binding protein 1 (SBP1) and glutathione peroxidase 1 (GPX1), in selenite-mediated cancer-specific cytotoxicity. Selenium 75-83 selenium binding protein 1 Homo sapiens 105-131 25445402-3 2015 This study was to investigate the roles of two distinct representatives of selenium-containing proteins, selenium-binding protein 1 (SBP1) and glutathione peroxidase 1 (GPX1), in selenite-mediated cancer-specific cytotoxicity. Selenium 75-83 selenium binding protein 1 Homo sapiens 133-137 25445402-7 2015 Furthermore, knockdown SBP1 by small interfering RNA increased selenite sensitivity by elevating extracellular glutathione (GSH), which spontaneously reacted with selenite and led to the rapid depletion of selenium (IV) in growth medium and the high-affinity uptake of selenite. Selenium 206-214 selenium binding protein 1 Homo sapiens 23-27 24163737-2 2013 Selenium-binding protein 1 (SBP1) is a member of an unusual class of selenium-containing proteins that may function as a tumor suppressor in multiple cancer types and whose levels have been shown to be lower in cancers as compared to corresponding normal tissues. Selenium 69-77 selenium binding protein 1 Homo sapiens 28-32 22848296-5 2011 Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Selenium 57-65 selenium binding protein 1 Homo sapiens 83-109 23704933-2 2013 The antitumor function of selenium is thought to be mediated through selenium-binding protein 1 (SELENBP1). Selenium 26-34 selenium binding protein 1 Homo sapiens 69-95 23704933-2 2013 The antitumor function of selenium is thought to be mediated through selenium-binding protein 1 (SELENBP1). Selenium 26-34 selenium binding protein 1 Homo sapiens 97-105 23704933-9 2013 In addition, selenium treatment resulted in reduced cell proliferation in endogenous SELENBP1 high cells; however, after knocking-down SELENBP1, we observed no significant reduction in cell proliferation. Selenium 13-21 selenium binding protein 1 Homo sapiens 85-93 23704933-12 2013 These data indicate that SELENBP1 expression is regulated via estrogen and that the cell proliferation inhibition effect of selenium treatment is dependent on the high level of SELENBP1 expression. Selenium 124-132 selenium binding protein 1 Homo sapiens 25-33 23704933-12 2013 These data indicate that SELENBP1 expression is regulated via estrogen and that the cell proliferation inhibition effect of selenium treatment is dependent on the high level of SELENBP1 expression. Selenium 124-132 selenium binding protein 1 Homo sapiens 177-185 23704933-13 2013 Therefore, the expression level of SELENBP1 could be an important marker for predicting survival and effectiveness of selenium supplementation in breast cancer. Selenium 118-126 selenium binding protein 1 Homo sapiens 35-43 22072582-2 2012 In addition, Se-containing proteins including members of the glutathione peroxidase (GPx) family and Selenium-Binding Protein 1 (SBP1) have been linked to either cancer risk or development. Selenium 13-15 selenium binding protein 1 Homo sapiens 101-127 22072582-2 2012 In addition, Se-containing proteins including members of the glutathione peroxidase (GPx) family and Selenium-Binding Protein 1 (SBP1) have been linked to either cancer risk or development. Selenium 13-15 selenium binding protein 1 Homo sapiens 129-133 22848296-5 2011 Furthermore, a significant correlation was found between selenium levels and human selenium binding protein-1 (SELENBP1) down-regulation in the liver. Selenium 57-65 selenium binding protein 1 Homo sapiens 111-119 20530237-6 2010 The opposing effects of SBP1 and GPX1 on each other were also observed when GPX1 was increased by supplementing the media of these tissue culture cells with selenium, and the effect of selenium on SBP1 was shown to be GPX1 dependent. Selenium 157-165 selenium binding protein 1 Homo sapiens 24-28 21338716-3 2011 Since the structure-function relationships of SELENBP1 are unknown, we have performed computational and experimental studies to have insight on the structural features of this protein focusing our attention on the properties of cysteines to assess their ability to interact with selenium. Selenium 279-287 selenium binding protein 1 Homo sapiens 46-54 21338716-6 2011 Our studies demonstrate that (i) SELENBP1 is an alpha-beta protein with some loop regions characterized by the presence of intrinsically unordered segments, (ii) only one cysteine (Cys57) is enough exposed to solvent, located on a loop and surrounded by charged and hydrophobic residues, and can be the cysteine able to bind the selenium. Selenium 329-337 selenium binding protein 1 Homo sapiens 33-41 20530237-6 2010 The opposing effects of SBP1 and GPX1 on each other were also observed when GPX1 was increased by supplementing the media of these tissue culture cells with selenium, and the effect of selenium on SBP1 was shown to be GPX1 dependent. Selenium 185-193 selenium binding protein 1 Homo sapiens 197-201 19896693-4 2010 The anticancer action of selenium has been suggested to be mediated by selenium-binding protein 1 as selenium-binding protein 1 is decreased in several cancers. Selenium 25-33 selenium binding protein 1 Homo sapiens 71-97 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 8-16 selenium binding protein 1 Homo sapiens 36-44 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 8-16 selenium binding protein 1 Homo sapiens 52-57 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 8-34 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 36-44 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 52-57 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 8-34 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 36-44 20332323-2 2010 Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its potential effect on chemosensitivity in the presence of selenium. Selenium 82-90 selenium binding protein 1 Homo sapiens 52-57 20332323-5 2010 WST-1 cell proliferation assays, senescence-associated beta-galactosidase staining, immunoblotting, and flow cytometry were done to evaluate the biological significance of SELENBP1 overexpression in selenium-supplemented EAC cells. Selenium 199-207 selenium binding protein 1 Homo sapiens 172-180 20332323-10 2010 CONCLUSIONS: SELENBP1 expression may be an important predictor of response to chemoprevention or chemosensitization with certain forms of selenium in esophageal tissues. Selenium 138-146 selenium binding protein 1 Homo sapiens 13-21 19896693-4 2010 The anticancer action of selenium has been suggested to be mediated by selenium-binding protein 1 as selenium-binding protein 1 is decreased in several cancers. Selenium 25-33 selenium binding protein 1 Homo sapiens 101-127 19118533-0 2009 Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner. Selenium 6-14 selenium binding protein 1 Homo sapiens 34-39 19118533-2 2009 hSP56 also has been implicated in selenium-dependent cell growth inhibition. Selenium 34-42 selenium binding protein 1 Homo sapiens 0-5 19118533-7 2009 The full-length VDU1 specifically interacted with a selenium-replete form of hSP56. Selenium 52-60 selenium binding protein 1 Homo sapiens 77-82 19118533-8 2009 We also demonstrate stable incorporation of selenium into hSP56, in a mode distinct from conventional selenocysteine-containing selenoproteins. Selenium 44-52 selenium binding protein 1 Homo sapiens 58-63 19118533-9 2009 These findings suggest that hSP56 may play a role in ubiquitination/deubiquitination-mediated protein degradation pathways in a selenium-dependent manner. Selenium 128-136 selenium binding protein 1 Homo sapiens 28-33