PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23038251-11 2012 In addition, selenium deficiency down-regulated the mRNA of the most abundant hepatic selenoprotein, glutathione peroxidase-1 (Gpx1), to 15% of the selenium-replete value, while reducing Sepp1 mRNA, the most abundant hepatic selenoprotein mRNA, only to 61%. Selenium 13-21 selenoprotein F Mus musculus 86-99 10692412-3 2000 The enzyme was proposed to function as a selenium delivery protein to selenophosphate synthetase in selenoprotein biosynthesis (Lacourciere, G. M., and Stadtman, T. C. (1998) J. Biol. Selenium 41-49 selenoprotein F Mus musculus 100-113 29338053-0 2018 Selenium regulation of selenoprotein enzyme activity and transcripts in a pilot study with Founder strains from the Collaborative Cross. Selenium 0-8 selenoprotein F Mus musculus 23-36 29338053-2 2018 In selenium (Se) deficiency, there is differential regulation of selenoprotein expression, whereby levels of some selenoproteins and their transcripts decrease dramatically in Se deficiency, but other selenoprotein transcripts are spared this decrease; the underlying mechanism, however, is not fully understood. Selenium 3-11 selenoprotein F Mus musculus 65-78 29338053-2 2018 In selenium (Se) deficiency, there is differential regulation of selenoprotein expression, whereby levels of some selenoproteins and their transcripts decrease dramatically in Se deficiency, but other selenoprotein transcripts are spared this decrease; the underlying mechanism, however, is not fully understood. Selenium 3-11 selenoprotein F Mus musculus 114-127 29338053-2 2018 In selenium (Se) deficiency, there is differential regulation of selenoprotein expression, whereby levels of some selenoproteins and their transcripts decrease dramatically in Se deficiency, but other selenoprotein transcripts are spared this decrease; the underlying mechanism, however, is not fully understood. Selenium 13-15 selenoprotein F Mus musculus 65-78 29338053-2 2018 In selenium (Se) deficiency, there is differential regulation of selenoprotein expression, whereby levels of some selenoproteins and their transcripts decrease dramatically in Se deficiency, but other selenoprotein transcripts are spared this decrease; the underlying mechanism, however, is not fully understood. Selenium 13-15 selenoprotein F Mus musculus 114-127 29338053-7 2018 These results indicate that differential regulation of selenoprotein expression by Se status is an essential aspect of Se metabolism and selenoprotein function. Selenium 83-85 selenoprotein F Mus musculus 55-68 29338053-7 2018 These results indicate that differential regulation of selenoprotein expression by Se status is an essential aspect of Se metabolism and selenoprotein function. Selenium 83-85 selenoprotein F Mus musculus 137-150 26461304-7 2014 As a selenoprotein, it requires unique translational machinery for its expression, as well as adequate selenium stores; its primary site of synthesis is the renal tubule, although all nucleated cells can express low levels of the enzyme. Selenium 103-111 selenoprotein F Mus musculus 5-18 23830627-0 2013 Selenoprotein W as biomarker for the efficacy of selenium compounds to act as source for selenoprotein biosynthesis. Selenium 49-57 selenoprotein F Mus musculus 89-102 23830627-5 2013 Thus, only compounds that can be metabolized into selenide can serve as sources for selenoprotein biosynthesis. Selenium 50-58 selenoprotein F Mus musculus 84-97 32210049-0 2020 Analysis of Selenoprotein Expression in Response to Dietary Selenium Deficiency During Pregnancy Indicates Tissue Specific Differential Expression in Mothers and Sex Specific Changes in the Fetus and Offspring. Selenium 60-68 selenoprotein F Mus musculus 12-25 32210049-2 2020 Since it is well known that selenium is important to maternal health and foetal development during pregnancy, this study aimed at defining the impact of selenium deficiency on maternal, placental, foetal and offspring selenoprotein gene expression. Selenium 153-161 selenoprotein F Mus musculus 218-231 31773160-0 2020 Knockout of Selenoprotein V Affects Regulation of Selenoprotein Expression by Dietary Selenium and Fat Intakes in Mice. Selenium 86-94 selenoprotein F Mus musculus 12-25 25867950-7 2015 Colonic selenoprotein expression was maximized in all selenium-supplemented groups independent of the selenocompound or intervention time. Selenium 54-62 selenoprotein F Mus musculus 8-21 24519931-5 2014 Selenocysteine lyase (Scly) is an enzyme that plays an important role in selenium homeostasis, in that it catalyzes the decomposition of selenocysteine and allows selenium to be recycled for additional selenoprotein synthesis. Selenium 73-81 selenoprotein F Mus musculus 202-215 24519931-5 2014 Selenocysteine lyase (Scly) is an enzyme that plays an important role in selenium homeostasis, in that it catalyzes the decomposition of selenocysteine and allows selenium to be recycled for additional selenoprotein synthesis. Selenium 163-171 selenoprotein F Mus musculus 202-215 25130740-1 2014 Selenite is a selenium source for selenoprotein biosynthesis in mammalian cells. Selenium 14-22 selenoprotein F Mus musculus 34-47 23651543-2 2013 The other extracellular selenoprotein, glutathione peroxidase-3 (Gpx3), has not been shown to transport selenium. Selenium 104-112 selenoprotein F Mus musculus 24-37 23651543-6 2013 Thus, two selenoprotein-dependent maternal-fetal selenium transfer mechanisms were identified. Selenium 49-57 selenoprotein F Mus musculus 10-23 23651543-11 2013 These findings indicate that the selenoprotein uptake mechanisms ensure selenium transfer to the fetus under selenium-deficient conditions. Selenium 72-80 selenoprotein F Mus musculus 33-46 23651543-11 2013 These findings indicate that the selenoprotein uptake mechanisms ensure selenium transfer to the fetus under selenium-deficient conditions. Selenium 109-117 selenoprotein F Mus musculus 33-46 23468186-0 2013 Selenium effect on selenoprotein transcriptome in chondrocytes. Selenium 0-8 selenoprotein F Mus musculus 19-32 23038251-11 2012 In addition, selenium deficiency down-regulated the mRNA of the most abundant hepatic selenoprotein, glutathione peroxidase-1 (Gpx1), to 15% of the selenium-replete value, while reducing Sepp1 mRNA, the most abundant hepatic selenoprotein mRNA, only to 61%. Selenium 13-21 selenoprotein F Mus musculus 225-238 22137268-5 2012 Genes for four selenoproteins, Sepw1, Gpx1, Selh and Sep15, were the most significantly down-regulated in moderate selenium deficiency, and this was confirmed by quantitative polymerase chain reaction (qPCR). Selenium 115-123 selenoprotein F Mus musculus 53-58 19769460-5 2010 We also examined regulation of Msr and selenoprotein expression by a combination of dietary selenium and calorie restriction and found that, under calorie restriction conditions, selenium regulation was preserved. Selenium 92-100 selenoprotein F Mus musculus 39-52 21768092-2 2011 Expression of Sep15 is regulated by dietary selenium and the unfolded protein response, but its specific function is not known. Selenium 44-52 selenoprotein F Mus musculus 14-19 20370716-0 2010 Selenium controls the sex-specific immune response and selenoprotein expression during the acute-phase response in mice. Selenium 0-8 selenoprotein F Mus musculus 55-68 20370716-11 2010 We conclude that selenoprotein biosynthesis becomes redirected in hepatocytes during the acute-phase response at the expense of dispensable selenoproteins (e.g. SepP) and in favour of SepS expression, thereby causing declining serum selenium and improving liver function. Selenium 233-241 selenoprotein F Mus musculus 17-30 20346189-0 2010 Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon. Selenium 0-8 selenoprotein F Mus musculus 58-71 20346189-0 2010 Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon. Selenium 36-44 selenoprotein F Mus musculus 58-71 20346189-2 2010 The present study compared the effects of an Se-enriched milk protein product (dairy-Se) with an Se yeast (yeast-Se) on selenoprotein activity and expression in the mouse colon. Selenium 45-47 selenoprotein F Mus musculus 120-133 20346189-8 2010 The present study indicates that selenoprotein levels in the mouse colon are regulated differently depending on the Se supplement. Selenium 116-118 selenoprotein F Mus musculus 33-46 22708491-7 2012 Several other RNA-binding proteins are involved in selenoprotein translation and mediate the hierarchical response of selenoproteins to selenium deficiency. Selenium 136-144 selenoprotein F Mus musculus 51-64 19769460-8 2010 Taken together, these findings better define dietary regulation of methionine sulfoxide reduction and selenoprotein expression in mice with regard to age, calorie restriction, dietary Se, and a combination of these factors. Selenium 184-186 selenoprotein F Mus musculus 102-115 19810021-3 2009 Therefore, microarrays were used to determine how both selenoprotein and global gene expression patterns in the mouse colon were affected by marginal selenium deficiency comparable to variations in human dietary intakes. Selenium 150-158 selenoprotein F Mus musculus 55-68 19863805-6 2009 CONCLUSION: Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages. Selenium 12-20 selenoprotein F Mus musculus 99-112 14519790-2 2003 Selenium deficiency, which can reduce selenoprotein levels, has been associated with several striated muscle pathologies. Selenium 0-8 selenoprotein F Mus musculus 38-51 19076066-0 2009 Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Selenium 0-8 selenoprotein F Mus musculus 33-46 16690748-7 2006 The selenoprotein-deficient mice exhibited accelerated development of lesions associated with prostate cancer progression, implicating selenoproteins in cancer risk and development and raising the possibility that selenium prevents cancer by modulating the levels of these selenoproteins. Selenium 214-222 selenoprotein F Mus musculus 4-17 18829286-6 2009 Under selenium-adequate conditions, selenoprotein expression did not differ in GF and CV mice. Selenium 6-14 selenoprotein F Mus musculus 36-49 14660662-2 2004 However, in adults, selenoprotein levels in several organs including liver can be substantially reduced by selenium deficiency without any apparent change in phenotype. Selenium 107-115 selenoprotein F Mus musculus 20-33