PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28115365-0	2017	Activation of PPARgamma by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia.	Selenium	91-99	peroxisome proliferator activated receptor gamma	Mus musculus	14-23	
28115365-4	2017	Here, we show that these endogenous CyPGs, produced by mice maintained on selenium-supplemented diets, alleviate the symptoms of CML through their ability to activate the nuclear hormone receptor, peroxisome proliferator activated receptor gamma (PPARgamma).	Selenium	74-82	peroxisome proliferator activated receptor gamma	Mus musculus	197-245	
28115365-4	2017	Here, we show that these endogenous CyPGs, produced by mice maintained on selenium-supplemented diets, alleviate the symptoms of CML through their ability to activate the nuclear hormone receptor, peroxisome proliferator activated receptor gamma (PPARgamma).	Selenium	74-82	peroxisome proliferator activated receptor gamma	Mus musculus	247-256	
28115365-5	2017	GW9662, a potent PPARgamma antagonist, blocked the antileukemic effect of selenium supplementation by significantly reducing CyPGs.	Selenium	74-82	peroxisome proliferator activated receptor gamma	Mus musculus	17-26	
28115365-6	2017	This effect was mediated by an increase in 15-prostaglandin dehydrogenase (15-Pgdh) activity, which oxidizes and inactivates Delta12-PGJ2 and 15d-PGJ2 In contrast, treatment with the PPARgamma agonist pioglitazone mimicked selenium supplementation.	Selenium	223-231	peroxisome proliferator activated receptor gamma	Mus musculus	183-192	
28115365-8	2017	Selenium-dependent activation of PPARgamma mediated by endogenous CyPGs decreased Stat5 expression leading to the downregulation of Cited2, a master regulator of LSC quiescence.	Selenium	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	33-42	
26644468-9	2016	Antagonism of PPARgamma blocked the effect of selenium.	Selenium	46-54	peroxisome proliferator activated receptor gamma	Mus musculus	14-23	
21775527-9	2011	Furthermore, BMDM treated with inhibitors of PPARgamma and STAT6, pivotal transcription factors that mediate the activity of Se and IL-4, respectively, showed complete ablation of Se-dependent expression of M2 markers.	Selenium	125-127	peroxisome proliferator activated receptor gamma	Mus musculus	45-54	
21775527-10	2011	In summary, these studies suggest that Se supplementation of macrophages produces endogenous activators to mediate the PPARgamma-dependent switch from M1 to M2 phenotype in the presence of IL-4, possibly affecting pathways of wound healing and inflammation resolution.	Selenium	39-41	peroxisome proliferator activated receptor gamma	Mus musculus	119-128