PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15539257-4 1999 Conjugases such as UDP- glucuronosyltransferases with substrates 3-OH benzo(a)pyrene (UGT1) and 4-hydroxybiphenyl (UGT2) and glutathione S-transferase (GST) with substrate 1-chloro-2,4-dinitrobenzene were higher by 72, 69, and 33% in RF and 28, 38, and 24% in rRF groups, respectively. Dinitrochlorobenzene 172-199 hematopoietic prostaglandin D synthase Rattus norvegicus 125-150 15539257-4 1999 Conjugases such as UDP- glucuronosyltransferases with substrates 3-OH benzo(a)pyrene (UGT1) and 4-hydroxybiphenyl (UGT2) and glutathione S-transferase (GST) with substrate 1-chloro-2,4-dinitrobenzene were higher by 72, 69, and 33% in RF and 28, 38, and 24% in rRF groups, respectively. Dinitrochlorobenzene 172-199 hematopoietic prostaglandin D synthase Rattus norvegicus 152-155 9879635-8 1998 Activities of GST toward 1-chloro-2,4-nitrobenzene and 3,4-dichloronitrobenzene were slightly induced (127-133% of control) in the liver of the rat treated with these pesticides. Dinitrochlorobenzene 25-50 hematopoietic prostaglandin D synthase Rattus norvegicus 14-17 9828219-5 1998 Total hepatic GST activity toward 1-chloro-2,4-dinitrobenzene was also significantly decreased. Dinitrochlorobenzene 34-61 hematopoietic prostaglandin D synthase Rattus norvegicus 14-17 9884320-6 1999 GST activity was measured using 1-chloro-2,4-dinitrobenzene as substrate. Dinitrochlorobenzene 32-59 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 10732701-5 1998 Hepatocytes obtained from SHR and IR rats showed the highest glutathione-S-transferase (GST) activity towards CDNB compared to the IS or W strain. Dinitrochlorobenzene 110-114 hematopoietic prostaglandin D synthase Rattus norvegicus 61-86 9675878-4 1998 When rats were fed curcumin at doses from 1 to 500 mg kg-1 body weight daily for 14 days, the induction of hepatic GST activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was found to be biphasic, with maximal induction of about 1.5 fold at the 25 to 50 mg kg-1 body weight dosage. Dinitrochlorobenzene 136-163 hematopoietic prostaglandin D synthase Rattus norvegicus 115-118 9675878-4 1998 When rats were fed curcumin at doses from 1 to 500 mg kg-1 body weight daily for 14 days, the induction of hepatic GST activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was found to be biphasic, with maximal induction of about 1.5 fold at the 25 to 50 mg kg-1 body weight dosage. Dinitrochlorobenzene 165-169 hematopoietic prostaglandin D synthase Rattus norvegicus 115-118 10732701-5 1998 Hepatocytes obtained from SHR and IR rats showed the highest glutathione-S-transferase (GST) activity towards CDNB compared to the IS or W strain. Dinitrochlorobenzene 110-114 hematopoietic prostaglandin D synthase Rattus norvegicus 88-91 8762135-1 1996 Reaction of rat liver glutathione S-transferase, isozyme 1-1, with 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, results in a time-dependent inactivation of the enzyme to a final value of 35% of its original activity when assayed at pH 6.5 with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 272-299 hematopoietic prostaglandin D synthase Rattus norvegicus 22-47 9877218-4 1998 Glutathione S-transferase activities were assayed using 1-chloro-2,4-dinitrobenzene as substrate. Dinitrochlorobenzene 56-83 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 9467831-1 1997 The status of cytochrome P450-dependent oxidative biotransformation of aminopyrine and benzo(a)pyrene (Phase I reaction) and glutathione S-transferase (GST) catalyzed conjugation with 1-chloro-2,4-dinitrobenzene (CDNB) (Phase II reaction) was evaluated in diabetic rats sacrificed 3 weeks after alloxan treatment (2 doses of 75 mg/kg at an interval of 48 h, i.p.). Dinitrochlorobenzene 184-211 hematopoietic prostaglandin D synthase Rattus norvegicus 125-150 9467831-1 1997 The status of cytochrome P450-dependent oxidative biotransformation of aminopyrine and benzo(a)pyrene (Phase I reaction) and glutathione S-transferase (GST) catalyzed conjugation with 1-chloro-2,4-dinitrobenzene (CDNB) (Phase II reaction) was evaluated in diabetic rats sacrificed 3 weeks after alloxan treatment (2 doses of 75 mg/kg at an interval of 48 h, i.p.). Dinitrochlorobenzene 184-211 hematopoietic prostaglandin D synthase Rattus norvegicus 152-155 9467831-1 1997 The status of cytochrome P450-dependent oxidative biotransformation of aminopyrine and benzo(a)pyrene (Phase I reaction) and glutathione S-transferase (GST) catalyzed conjugation with 1-chloro-2,4-dinitrobenzene (CDNB) (Phase II reaction) was evaluated in diabetic rats sacrificed 3 weeks after alloxan treatment (2 doses of 75 mg/kg at an interval of 48 h, i.p.). Dinitrochlorobenzene 213-217 hematopoietic prostaglandin D synthase Rattus norvegicus 125-150 9467831-1 1997 The status of cytochrome P450-dependent oxidative biotransformation of aminopyrine and benzo(a)pyrene (Phase I reaction) and glutathione S-transferase (GST) catalyzed conjugation with 1-chloro-2,4-dinitrobenzene (CDNB) (Phase II reaction) was evaluated in diabetic rats sacrificed 3 weeks after alloxan treatment (2 doses of 75 mg/kg at an interval of 48 h, i.p.). Dinitrochlorobenzene 213-217 hematopoietic prostaglandin D synthase Rattus norvegicus 152-155 9310148-12 1997 Hyperthyroidism also diminished microsomal GST activity, and altered GST kinetics for both GSH and 1-chloro-2,4-dinitrobenzene (CDNB). Dinitrochlorobenzene 99-126 hematopoietic prostaglandin D synthase Rattus norvegicus 69-72 9310148-12 1997 Hyperthyroidism also diminished microsomal GST activity, and altered GST kinetics for both GSH and 1-chloro-2,4-dinitrobenzene (CDNB). Dinitrochlorobenzene 128-132 hematopoietic prostaglandin D synthase Rattus norvegicus 69-72 9363843-12 1997 The hepatic GST activities toward CDNB and DCNB decreased significantly in 360-day-old rats and were unaltered in the younger age groups. Dinitrochlorobenzene 34-38 hematopoietic prostaglandin D synthase Rattus norvegicus 12-15 9021168-4 1996 In lung, EtOH increased GST activities toward CDNB and ENPP and LP level but decreased GST activity toward DCNB, significantly. Dinitrochlorobenzene 46-50 hematopoietic prostaglandin D synthase Rattus norvegicus 24-27 9021168-12 1996 Combined treatment significantly decreased GST activity toward CDNB, ameliorated the alteration caused by either EtOH or CS treatment alone on GST activity toward EAA and potentiated the depression of GST activity toward ENPP to a greater degree. Dinitrochlorobenzene 63-67 hematopoietic prostaglandin D synthase Rattus norvegicus 43-46 9021168-15 1996 GST activities toward CDNB, DCNB and ENPP were highly elevated by the combined treatment. Dinitrochlorobenzene 22-26 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 8762135-1 1996 Reaction of rat liver glutathione S-transferase, isozyme 1-1, with 4-(fluorosulfonyl)benzoic acid (4-FSB), a xenobiotic substrate analogue, results in a time-dependent inactivation of the enzyme to a final value of 35% of its original activity when assayed at pH 6.5 with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 301-305 hematopoietic prostaglandin D synthase Rattus norvegicus 22-47 20650114-4 1995 Cytosolic GST activities were assayed spectrophotometrically using 1-chloro-2,4-dinitrobenzene (CDNB) or 1,2-dichloro-4-nitrobenzene (DCNB) as substrates. Dinitrochlorobenzene 67-94 hematopoietic prostaglandin D synthase Rattus norvegicus 10-13 8867999-10 1996 1-Chloro-2,4-dinitrobenzene and 2-chloro-5-nitrobenzonitrile were most efficiently conjugated by all four GST-isoenzymes examined. Dinitrochlorobenzene 0-27 hematopoietic prostaglandin D synthase Rattus norvegicus 106-109 8867999-12 1996 When the rate of the conjugation reactions was followed, a linear increase of formation of GS-conjugate could be seen for 2-chloro-5-nitrobenzonitrile during a much longer period of time than for 1-chloro-2,4-dinitrobenzene with all GST-isoenzymes examined. Dinitrochlorobenzene 196-223 hematopoietic prostaglandin D synthase Rattus norvegicus 233-236 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 216-243 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 216-243 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 245-249 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 8534266-7 1996 Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate. Dinitrochlorobenzene 245-249 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 7671242-9 1995 Accordingly, GST conjugation activity measured with 1-chloro-2,4-dinitrobenzene as substrate increased 1.5-, 1.8-, or 2.4-fold for the once-weekly, twice-weekly or daily treatments, respectively, throughout a 7-day period. Dinitrochlorobenzene 52-79 hematopoietic prostaglandin D synthase Rattus norvegicus 13-16 8627517-11 1996 ADS, AS or PS treatment caused increases in the glutathione S-transferase (GST) conjugating activity toward 1-chloro-2,4-dinitro-benzene. Dinitrochlorobenzene 108-136 hematopoietic prostaglandin D synthase Rattus norvegicus 48-73 8627517-11 1996 ADS, AS or PS treatment caused increases in the glutathione S-transferase (GST) conjugating activity toward 1-chloro-2,4-dinitro-benzene. Dinitrochlorobenzene 108-136 hematopoietic prostaglandin D synthase Rattus norvegicus 75-78 8801059-3 1996 In this study, GST activities were detected in the hepatic cytosolic and sonic-disrupted mitoplast fractions isolated from male Sprague-Dawley rats by using 1-chloro-2,4-dinitrobenzene as a substrate. Dinitrochlorobenzene 157-184 hematopoietic prostaglandin D synthase Rattus norvegicus 15-18 7797568-5 1995 Both proteins showed activity toward the GST substrate 1-chloro-2,4-dinitrobenzene (Km of 33 microM and 50 microM) which was inhibited by 17 beta-estradiol 3-sulfate. Dinitrochlorobenzene 55-82 hematopoietic prostaglandin D synthase Rattus norvegicus 41-44 20650114-4 1995 Cytosolic GST activities were assayed spectrophotometrically using 1-chloro-2,4-dinitrobenzene (CDNB) or 1,2-dichloro-4-nitrobenzene (DCNB) as substrates. Dinitrochlorobenzene 96-100 hematopoietic prostaglandin D synthase Rattus norvegicus 10-13 20650114-5 1995 When cultures were exposed to 0.4% EtOH the total GST activity towards the substrate CDNB increased by 35%. Dinitrochlorobenzene 85-89 hematopoietic prostaglandin D synthase Rattus norvegicus 50-53 8960250-3 1995 Cytosolic liver glutathione S-transferase (GST) activity was decreased for CDNB and DCNB as substrates in long term alloxan induced diabetes. Dinitrochlorobenzene 75-79 hematopoietic prostaglandin D synthase Rattus norvegicus 16-41 8960250-3 1995 Cytosolic liver glutathione S-transferase (GST) activity was decreased for CDNB and DCNB as substrates in long term alloxan induced diabetes. Dinitrochlorobenzene 75-79 hematopoietic prostaglandin D synthase Rattus norvegicus 43-46 8960250-4 1995 Similar to cytosolic, microsomal glutathione S-transferase activity was also decreased for CDNB. Dinitrochlorobenzene 91-95 hematopoietic prostaglandin D synthase Rattus norvegicus 33-58 8960251-4 1995 The activity of cytosol glutathione S-transferase (GST) was decreased to 55% of the control with p-nitrobenzyl chloride, and was unchanged with 1-chloro-2,4-dinitrobenzene, and ethacrynic acid. Dinitrochlorobenzene 144-171 hematopoietic prostaglandin D synthase Rattus norvegicus 51-54 7532609-4 1995 Intestinal GST activities against CDNB and epoxynitrophenoxypropane did not change with goitrin or T3 treatment. Dinitrochlorobenzene 34-38 hematopoietic prostaglandin D synthase Rattus norvegicus 11-14 7726643-8 1995 In addition to cytochrome P450-mediated monooxygenases, there was significant induction of the Phase II drug-metabolizing enzymes, DT-diaphorase, glutathione S-transferase activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and UDP-glucuronyltransferase activities towards 4-nitrophenol and 7-hydroxycoumarin. Dinitrochlorobenzene 191-218 hematopoietic prostaglandin D synthase Rattus norvegicus 146-171 8020884-6 1994 Cytosolic glutathione S-transferase activity for trans-4-phenyl-3-buten-2-one in advanced tumors ranged from 42% to 66% of the activity in matched surrounding liver, whereas glutathione S-transferase activities for 1-chloro-2,4-dinitrobenzene were increased by 140% to 161%. Dinitrochlorobenzene 215-242 hematopoietic prostaglandin D synthase Rattus norvegicus 174-199 8053925-8 1994 Total GST, measured with CDNB, was reduced by 17%. Dinitrochlorobenzene 25-29 hematopoietic prostaglandin D synthase Rattus norvegicus 6-9 7518676-2 1994 Consumption of either the selenium-deficient or high selenium diet increased activity of glutathione S-transferase, measured with 1-chloro-2,4-dinitrobenzene as substrate, compared to the control diet. Dinitrochlorobenzene 130-157 hematopoietic prostaglandin D synthase Rattus norvegicus 89-114 8200068-3 1994 Moreover, BC treatment throughout the study decrease the cytosolic 1-chloro-2,4-dinitrobenzene conjugated glutathione S-transferase (38.9-51.22%) and microsomal UDP-glucuronyl transferase (37.3-59.1%) activities to a significant level when compared to carcinogen control rats. Dinitrochlorobenzene 67-94 hematopoietic prostaglandin D synthase Rattus norvegicus 106-131 8406240-7 1993 Enhancement of cytosolic glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene was found for all eugenol- and trans-anethole-treated rats. Dinitrochlorobenzene 74-101 hematopoietic prostaglandin D synthase Rattus norvegicus 25-50 8166662-4 1994 Freshly isolated lipocytes contained GST activity when assayed with chlorodinitrobenzene (680 nmol/min per mg), and expression of Alpha, Mu and Pi forms of GST was detected by Western-blot analysis. Dinitrochlorobenzene 68-88 hematopoietic prostaglandin D synthase Rattus norvegicus 37-40 8406240-7 1993 Enhancement of cytosolic glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene was found for all eugenol- and trans-anethole-treated rats. Dinitrochlorobenzene 74-101 hematopoietic prostaglandin D synthase Rattus norvegicus 52-55 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Dinitrochlorobenzene 139-166 hematopoietic prostaglandin D synthase Rattus norvegicus 74-99 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Dinitrochlorobenzene 139-166 hematopoietic prostaglandin D synthase Rattus norvegicus 101-104 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Dinitrochlorobenzene 168-172 hematopoietic prostaglandin D synthase Rattus norvegicus 74-99 8103437-2 1993 The acute combined effects of cadmium (Cd) and nickel (Ni) on rat hepatic glutathione S-transferase (GST) activities toward the substrates 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB) and ethacrynic acid (EAA) were determined and compared to those of Cd or Ni alone. Dinitrochlorobenzene 168-172 hematopoietic prostaglandin D synthase Rattus norvegicus 101-104 1540144-1 1992 Methylation of glutathione S-transferase 11-11 inhibits conjugating activity towards 1-chloro-2,4-dinitrobenzene. Dinitrochlorobenzene 85-112 hematopoietic prostaglandin D synthase Rattus norvegicus 15-40 2125759-7 1990 Intraperitoneal, intragastric and all BSO-drinking water exposures also significantly induced (130-195%) cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene. Dinitrochlorobenzene 157-184 hematopoietic prostaglandin D synthase Rattus norvegicus 115-140 2052025-4 1991 Not correlatively, the catalytic activities of glutathione S-transferase towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene were significantly lowered in last stages of the experimental fascioliasis (by week 6 and 9 post-infection). Dinitrochlorobenzene 81-108 hematopoietic prostaglandin D synthase Rattus norvegicus 47-72 2781558-6 1989 The inhibitory effect of haloacetonitriles (HAN) on hepatic GST activity toward CDNB was found to be a mixed type. Dinitrochlorobenzene 80-84 hematopoietic prostaglandin D synthase Rattus norvegicus 60-63 2317812-6 1990 Overall GST activity, as measured by conjugation with 1,2-dichloro-4-nitrobenzene or 1-chloro-2,4-dinitrobenzene, as well as the levels of GST Ya protein, was elevated 1.5-fold by 24 h and maximally (2.7- to 3.5-fold) and persistently after 5 days on a purified diet supplemented with 0.075% oltipraz. Dinitrochlorobenzene 85-112 hematopoietic prostaglandin D synthase Rattus norvegicus 8-11 2178745-1 1990 The activity of in vitro glutathione S-transferase towards 1-chloro-2,4-dinitrobenzene was examined in liver, renal cortex, and small intestine (duodenum, jejunum, ileum) after the in vivo treatment of male Wistar rats with streptozotocin or alloxan. Dinitrochlorobenzene 59-86 hematopoietic prostaglandin D synthase Rattus norvegicus 25-50 2304451-3 1990 The inductive effect of 1,2-benzanthracene on cytochrome P450IA1 and glutathione S-transferase (1-chloro-2,4-dinitrobenzene conjugation) activities was potentiated approximately 3- and 2- to 3-fold, respectively, when dexamethasone (0.01-1 microM) was included in the culture medium. Dinitrochlorobenzene 96-123 hematopoietic prostaglandin D synthase Rattus norvegicus 69-94 2619713-2 1989 In untreated rats glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene and 4-hydroxynon-2-trans-enal as substrates was 1.7-2.2-fold higher in parenchymal cells than in Kupffer and endothelial cells, whereas total, selenium-dependent and non-selenium-dependent glutathione peroxidase activities were similar in all three cell types. Dinitrochlorobenzene 58-85 hematopoietic prostaglandin D synthase Rattus norvegicus 18-43 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Dinitrochlorobenzene 88-115 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Dinitrochlorobenzene 88-115 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Dinitrochlorobenzene 117-121 hematopoietic prostaglandin D synthase Rattus norvegicus 40-65 2635735-1 1989 The in vitro effect of phenobarbital on glutathione S-transferase (GST) activity toward 1-chloro-2,4-dinitrobenzene (CDNB) in rat hepatocyte culture was investigated. Dinitrochlorobenzene 117-121 hematopoietic prostaglandin D synthase Rattus norvegicus 67-70 2612064-5 1989 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Dinitrochlorobenzene 90-117 hematopoietic prostaglandin D synthase Rattus norvegicus 8-33 2612064-5 1989 Hepatic glutathione S-transferase activity was determined with five different substrates: 1-chloro-2,4-dinitrobenzene (CDNB), 1,2-dichloro-4-nitrobenzene (DCNB), p-nitro-benzyl chloride (PNBC), ethacrynic acid (EA) and trans-4-phenyl-3-buten-2-one (TPBO). Dinitrochlorobenzene 119-123 hematopoietic prostaglandin D synthase Rattus norvegicus 8-33 2612064-7 1989 The largest increases in glutathione S-transferase activity were found with CDNB, DCNB and PNBC (+61%, +50% and +50%, respectively, when expressed per mg of cytosolic protein). Dinitrochlorobenzene 76-80 hematopoietic prostaglandin D synthase Rattus norvegicus 25-50 2753164-2 1989 Glutathione S-transferase (GST) activities, using 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrates, were increased when PB was present in the culture medium. Dinitrochlorobenzene 50-77 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 2753164-2 1989 Glutathione S-transferase (GST) activities, using 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrates, were increased when PB was present in the culture medium. Dinitrochlorobenzene 50-77 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 2755320-5 1989 Clofibrate treatment significantly increased liver weight; as a result glutathione S-transferase activity (toward 1-chloro-2,4-dinitrobenzene) fell if expressed per gram of liver (4560 +/- 420 (SE) vs 7010 +/- 260 nmoles/min for clofibrate treated and controls respectively, p less than 0.002), but was unchanged when expressed per total liver (60.8 +/- 6.5 vs 64.6 +/- 3.5 mumoles/min for clofibrate and controls p greater than 0.5). Dinitrochlorobenzene 114-141 hematopoietic prostaglandin D synthase Rattus norvegicus 71-96 2742599-1 1989 Walker 256 rat mammary carcinoma cells resistant to chlorambucil (WR) exhibited an approximate 4-fold increase in glutathione S-transferase (GST) activity using 1-chloro-2,4-dinitrobenzene as compared to the sensitive parent cell line (WS). Dinitrochlorobenzene 161-188 hematopoietic prostaglandin D synthase Rattus norvegicus 114-139 2742599-1 1989 Walker 256 rat mammary carcinoma cells resistant to chlorambucil (WR) exhibited an approximate 4-fold increase in glutathione S-transferase (GST) activity using 1-chloro-2,4-dinitrobenzene as compared to the sensitive parent cell line (WS). Dinitrochlorobenzene 161-188 hematopoietic prostaglandin D synthase Rattus norvegicus 141-144 2930195-1 1989 The regulation of purified glutathione S-transferase from rat liver microsomes was studied by examining the effects of various sulfhydryl reagents on enzyme activity with 1-chloro-2,4-dinitrobenzene as the substrate. Dinitrochlorobenzene 171-198 hematopoietic prostaglandin D synthase Rattus norvegicus 27-52 3149822-10 1988 Glutathione S-transferase ranged from 9.5 to 23.6 mumol/min per g with p-nitrobenzyl chloride and from 29.1 to 66.8 mumol/min per g with 1-chloro-2,4-dinitrobenzene, peaking at week 51 with both substrates. Dinitrochlorobenzene 137-164 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 3169012-7 1988 The Yn1Yn1 form had glutathione S-transferase activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene. Dinitrochlorobenzene 65-92 hematopoietic prostaglandin D synthase Rattus norvegicus 20-45 3421996-6 1988 Perhexiline maleate significantly reduced liver glutathione S-transferase activities toward BSP (-25%), 3,4-dichloronitrobenzene (DCNB) (-21%) and 1-chloro-3,4-dinitrobenzene (DNCB) (-27%). Dinitrochlorobenzene 176-180 hematopoietic prostaglandin D synthase Rattus norvegicus 48-73 3377798-1 1988 Multiple halothane anesthesias (1.25 MAC for 1 hr on 3 alternate days) of male Long-Evans rats initially decreased by up to 30% and subsequently increased to up to 185% liver cytosolic glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene, 3,4-dichloro-1-nitrobenzene and trans-4-phenyl-3-buten-2-one and glutathione peroxidase activity. Dinitrochlorobenzene 227-254 hematopoietic prostaglandin D synthase Rattus norvegicus 185-210 3083094-4 1986 Glutathione-S-transferase (1-chloro-2,4-dinitrobenzene) activity was also unchanged through the various age groups. Dinitrochlorobenzene 27-54 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 3124855-13 1988 The highest glutathione-S-transferase (GST) activity, however, was towards the substrate 1-chloro-2,4-dinitrobenzene; the basal specific enzyme activity varied from about 0.05 to 0.2 mumol per min per mg protein in cells from crypt to upper villus. Dinitrochlorobenzene 89-116 hematopoietic prostaglandin D synthase Rattus norvegicus 12-37 3124855-13 1988 The highest glutathione-S-transferase (GST) activity, however, was towards the substrate 1-chloro-2,4-dinitrobenzene; the basal specific enzyme activity varied from about 0.05 to 0.2 mumol per min per mg protein in cells from crypt to upper villus. Dinitrochlorobenzene 89-116 hematopoietic prostaglandin D synthase Rattus norvegicus 39-42 3435464-1 1987 Selenium (Se) deficiency in rats produced significant increases in the activity of hepatic glutathione S-transferase (GST) with 1-chloro-2,4-dinitrobenzene as substrate and in various GST isoenzymes when determined by radioimmunoassay. Dinitrochlorobenzene 128-155 hematopoietic prostaglandin D synthase Rattus norvegicus 91-116 3435464-1 1987 Selenium (Se) deficiency in rats produced significant increases in the activity of hepatic glutathione S-transferase (GST) with 1-chloro-2,4-dinitrobenzene as substrate and in various GST isoenzymes when determined by radioimmunoassay. Dinitrochlorobenzene 128-155 hematopoietic prostaglandin D synthase Rattus norvegicus 118-121 3435531-1 1987 With 1-chloro-2,4-dinitrobenzene as the electrophilic substrate, the specific activity of glutathione S-transferase in rat haemolysates was found to range from 0.002 to 0.013 mumol/min/mg haemoglobin at 30 degrees C. To establish the glutathione S-transferase composition, chromatofocusing was used which indicated the presence of a single soluble isoenzyme with an apparent pI of 6.1. Dinitrochlorobenzene 5-32 hematopoietic prostaglandin D synthase Rattus norvegicus 90-115 3435531-1 1987 With 1-chloro-2,4-dinitrobenzene as the electrophilic substrate, the specific activity of glutathione S-transferase in rat haemolysates was found to range from 0.002 to 0.013 mumol/min/mg haemoglobin at 30 degrees C. To establish the glutathione S-transferase composition, chromatofocusing was used which indicated the presence of a single soluble isoenzyme with an apparent pI of 6.1. Dinitrochlorobenzene 5-32 hematopoietic prostaglandin D synthase Rattus norvegicus 234-259 3815855-4 1986 Thyroid hormone administration produced a significant fall in the hepatic content of GST YaYa and in total GST activity, as assessed using 1-chloro-2,4-dinitrobenzene as substrate. Dinitrochlorobenzene 139-166 hematopoietic prostaglandin D synthase Rattus norvegicus 107-110 2966795-6 1988 Similar changes were observed using 1-chloro-2,4-dinitrobenzene or 1,2-dichloro-4-nitrobenzene as substrates for GST. Dinitrochlorobenzene 36-63 hematopoietic prostaglandin D synthase Rattus norvegicus 113-116 3355583-3 1988 Hepatic cytosolic glutathione S-transferase (GST) activity was determined with the substrates 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, ethacrynic acid and trans-4-phenyl-3-buten-2-one. Dinitrochlorobenzene 94-121 hematopoietic prostaglandin D synthase Rattus norvegicus 18-43 3355583-3 1988 Hepatic cytosolic glutathione S-transferase (GST) activity was determined with the substrates 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, ethacrynic acid and trans-4-phenyl-3-buten-2-one. Dinitrochlorobenzene 94-121 hematopoietic prostaglandin D synthase Rattus norvegicus 45-48 3355583-5 1988 GST activity toward 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene and ethacrynic acid was enhanced by all compounds, hexachlorobenzene and 3-methylcholanthrene causing the largest and the smallest increase respectively. Dinitrochlorobenzene 20-47 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 3080823-10 1986 Glutathione S-transferase was induced differentially by these hydrocarbons toward various substrates: toward 1-chloro-2,4-dinitrobenzene by benzene and toluene, toward 1,2-dichloro-4-nitrobenzene by benzene and xylenes, and no effect toward 1,2-epoxy-3-(p-nitrophenoxy)propane by any hydrocarbons. Dinitrochlorobenzene 109-136 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 4062964-4 1985 In contrast, the GST activity towards CDNB in male rats did not show much of an age-associated alteration. Dinitrochlorobenzene 38-42 hematopoietic prostaglandin D synthase Rattus norvegicus 17-20 4085662-7 1985 The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively. Dinitrochlorobenzene 249-276 hematopoietic prostaglandin D synthase Rattus norvegicus 37-40 4085662-7 1985 The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively. Dinitrochlorobenzene 249-276 hematopoietic prostaglandin D synthase Rattus norvegicus 150-153 4085662-7 1985 The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively. Dinitrochlorobenzene 249-276 hematopoietic prostaglandin D synthase Rattus norvegicus 150-153 4004933-1 1985 Seven soluble rat liver glutathione S-transferase isozymes were isolated and the inhibition of these isozymes by selected diuretics was investigated using 1-chloro-2,4-dinitrobenzene as substrate. Dinitrochlorobenzene 155-182 hematopoietic prostaglandin D synthase Rattus norvegicus 24-49 4004801-2 1985 In selenium and vitamin E deficiency, the total activity of the GSH-px became very low, and the total activity of GST with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate was enhanced. Dinitrochlorobenzene 123-150 hematopoietic prostaglandin D synthase Rattus norvegicus 114-117 4004801-2 1985 In selenium and vitamin E deficiency, the total activity of the GSH-px became very low, and the total activity of GST with 1-chloro-2,4-dinitrobenzene (CDNB) as substrate was enhanced. Dinitrochlorobenzene 152-156 hematopoietic prostaglandin D synthase Rattus norvegicus 114-117 4004801-3 1985 Study of the time course of these changes as deficiency progressed indicated that the stimulus for the rise in GST (CDNB) activity was the fall in GSH-px activity which preceded it. Dinitrochlorobenzene 116-120 hematopoietic prostaglandin D synthase Rattus norvegicus 111-114 6523524-5 1984 Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes. Dinitrochlorobenzene 62-89 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 6523524-5 1984 Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes. Dinitrochlorobenzene 62-89 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 6523524-5 1984 Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes. Dinitrochlorobenzene 91-95 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 6523524-5 1984 Glutathione-S-transferase (GST) activity using acrylamide and 1-chloro 2,4-dinitrobenzene (CDNB) as substrates followed the order: liver greater than kidney greater than brain greater than erythrocytes. Dinitrochlorobenzene 91-95 hematopoietic prostaglandin D synthase Rattus norvegicus 27-30 6505381-1 1984 The in vitro interaction of butyric acid, crotonic acid and n-butylamine with rat liver glutathione S-transferase (GST) was studied, using glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates. Dinitrochlorobenzene 161-188 hematopoietic prostaglandin D synthase Rattus norvegicus 88-113 6505381-1 1984 The in vitro interaction of butyric acid, crotonic acid and n-butylamine with rat liver glutathione S-transferase (GST) was studied, using glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates. Dinitrochlorobenzene 161-188 hematopoietic prostaglandin D synthase Rattus norvegicus 115-118 6505381-1 1984 The in vitro interaction of butyric acid, crotonic acid and n-butylamine with rat liver glutathione S-transferase (GST) was studied, using glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates. Dinitrochlorobenzene 190-194 hematopoietic prostaglandin D synthase Rattus norvegicus 88-113 6505381-1 1984 The in vitro interaction of butyric acid, crotonic acid and n-butylamine with rat liver glutathione S-transferase (GST) was studied, using glutathione (GSH) and 1-chloro-2,4-dinitrobenzene (CDNB) as substrates. Dinitrochlorobenzene 190-194 hematopoietic prostaglandin D synthase Rattus norvegicus 115-118 18082333-6 2008 Chronic lithium treatment increased GST enzyme activity when 1-chloro-2, 4-dinitrobenzene and 4-hydroxynonenal were used as substrates. Dinitrochlorobenzene 61-89 hematopoietic prostaglandin D synthase Rattus norvegicus 36-39 6686184-1 1983 The in vitro interaction of four chlorophenoxyalkyl (CPA) acid herbicides with rat-liver glutathione S-transferase (GST) was studied using reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Dinitrochlorobenzene 163-190 hematopoietic prostaglandin D synthase Rattus norvegicus 89-114 6686184-1 1983 The in vitro interaction of four chlorophenoxyalkyl (CPA) acid herbicides with rat-liver glutathione S-transferase (GST) was studied using reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Dinitrochlorobenzene 163-190 hematopoietic prostaglandin D synthase Rattus norvegicus 116-119 6623534-1 1983 The soluble glutathione S-transferase (GST) isoenzymes in rat brain were investigated using 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate. Dinitrochlorobenzene 92-119 hematopoietic prostaglandin D synthase Rattus norvegicus 12-37 6623534-1 1983 The soluble glutathione S-transferase (GST) isoenzymes in rat brain were investigated using 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate. Dinitrochlorobenzene 92-119 hematopoietic prostaglandin D synthase Rattus norvegicus 39-42 6623534-1 1983 The soluble glutathione S-transferase (GST) isoenzymes in rat brain were investigated using 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate. Dinitrochlorobenzene 121-125 hematopoietic prostaglandin D synthase Rattus norvegicus 12-37 6623534-1 1983 The soluble glutathione S-transferase (GST) isoenzymes in rat brain were investigated using 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate. Dinitrochlorobenzene 121-125 hematopoietic prostaglandin D synthase Rattus norvegicus 39-42 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 38-41 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 73-76 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 73-76 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 73-76 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 73-76 6623534-2 1983 The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. Dinitrochlorobenzene 33-37 hematopoietic prostaglandin D synthase Rattus norvegicus 73-76 7112564-2 1982 GST was measured with 1-chloro-2,4-dinitrobenzene as the second substrate. Dinitrochlorobenzene 22-49 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 7325995-1 1981 Hepatic glutathione S-transferase activities were determined with the substrates 1,2-dichloro-4-nitrobenzene and 1-chloro-2,4-dinitrobenzene. Dinitrochlorobenzene 113-140 hematopoietic prostaglandin D synthase Rattus norvegicus 8-33 28104439-5 2017 Of the seven PAHs, only benzo[g]chrysene elevated glutathione S-transferase activity, measured using 1-chloro-2,4-dinitrobenzene or 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole as substrates. Dinitrochlorobenzene 101-128 hematopoietic prostaglandin D synthase Rattus norvegicus 50-75 26412696-3 2015 The activity of liver GST toward a universal substrate, CDNB, was increased in curcumin-administered rats. Dinitrochlorobenzene 56-60 hematopoietic prostaglandin D synthase Rattus norvegicus 22-25 6472435-1 1984 The in vitro interaction of the mycotoxin penicillic acid (PA) with rat liver glutathione S-transferase (GST) was studied using reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Dinitrochlorobenzene 152-179 hematopoietic prostaglandin D synthase Rattus norvegicus 105-108 6464504-6 1984 PTU treatment caused increase in GST activity using 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, p-nitrobenzyl chloride, and benzalacetone as substrates; enzyme activity towards chlorodinitrobenzene was the highest. Dinitrochlorobenzene 52-79 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 6464504-6 1984 PTU treatment caused increase in GST activity using 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, p-nitrobenzyl chloride, and benzalacetone as substrates; enzyme activity towards chlorodinitrobenzene was the highest. Dinitrochlorobenzene 191-211 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 6712662-3 1984 Glutathione conjugation of 1-chloro-2,4-dinitrobenzene by this isozyme, designated glutathione S-transferase VII, was inhibited 44 and 68% at indomethacin concentrations of 0.20 and 1.00 microM, respectively. Dinitrochlorobenzene 27-54 hematopoietic prostaglandin D synthase Rattus norvegicus 83-108 7147266-6 1982 GST C was the most abundant CDNB-GST isoenzyme (76%) in rat prostate, followed by GST A (17%) and GST AA (7%), significant amounts of other isoenzymes not being found. Dinitrochlorobenzene 28-32 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 7147266-6 1982 GST C was the most abundant CDNB-GST isoenzyme (76%) in rat prostate, followed by GST A (17%) and GST AA (7%), significant amounts of other isoenzymes not being found. Dinitrochlorobenzene 28-32 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 7147266-6 1982 GST C was the most abundant CDNB-GST isoenzyme (76%) in rat prostate, followed by GST A (17%) and GST AA (7%), significant amounts of other isoenzymes not being found. Dinitrochlorobenzene 28-32 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 7147266-6 1982 GST C was the most abundant CDNB-GST isoenzyme (76%) in rat prostate, followed by GST A (17%) and GST AA (7%), significant amounts of other isoenzymes not being found. Dinitrochlorobenzene 28-32 hematopoietic prostaglandin D synthase Rattus norvegicus 33-36 7083399-2 1982 P-450 enzymic activity was assayed by N-demethylation of p-chloro-N-methylaniline and 1-chloro-2,4-dinitrobenzene was used as substrate for glutathione S-transferase activity. Dinitrochlorobenzene 86-113 hematopoietic prostaglandin D synthase Rattus norvegicus 140-165 7093510-1 1982 Variation in the activity of superoxide dismutase, glutathione peroxidase (tretbutyl hydroperoxide as a substrate) and glutathione-S-transferase (1-chloro-2,4-dinitrobenzene as a substrate) was studied in rat ischemia and in coronaro-occlusion myocardial infarction. Dinitrochlorobenzene 146-173 hematopoietic prostaglandin D synthase Rattus norvegicus 119-144 7340827-9 1981 70% of the total glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene. Dinitrochlorobenzene 57-84 hematopoietic prostaglandin D synthase Rattus norvegicus 17-42 7340827-12 1981 Inhibitory kinetics suggested that sulphobromophthalein and Rose Bengal were non-competitive inhibitors of glutathione S-transferase activities when 1-chloro-2,4-dinitrobenzene was used as substrate for both PLAT Y(1) and PLAT Y(2). Dinitrochlorobenzene 149-176 hematopoietic prostaglandin D synthase Rattus norvegicus 107-132 15468054-5 2004 Conversely, hepatic glutathione S-transferase (GST) activity/expression increased, e.g., 3-4 fold toward 1-chloro-2,4-dinitrobenzene (total activity), up to 23-fold toward 4-vinylpyridine (rGSTP1), and approximately 7-fold for rGSTA2 protein. Dinitrochlorobenzene 105-132 hematopoietic prostaglandin D synthase Rattus norvegicus 20-45 17122891-2 2007 This phenomenon was accompanied by a fivefold increase in total glutathione S-transferase (GST) activity, measured with the broad-spectrum substrate 1-chloro-2,4-dinitrobenzene, in the N-OH-PhIP-resistant IEC-18 cells. Dinitrochlorobenzene 149-176 hematopoietic prostaglandin D synthase Rattus norvegicus 64-89 17122891-2 2007 This phenomenon was accompanied by a fivefold increase in total glutathione S-transferase (GST) activity, measured with the broad-spectrum substrate 1-chloro-2,4-dinitrobenzene, in the N-OH-PhIP-resistant IEC-18 cells. Dinitrochlorobenzene 149-176 hematopoietic prostaglandin D synthase Rattus norvegicus 91-94 15497818-4 2004 GST activity toward the broad substrate 1-chloro-2,4-dinitrobenzene was enhanced by TA. Dinitrochlorobenzene 40-67 hematopoietic prostaglandin D synthase Rattus norvegicus 0-3 15468054-5 2004 Conversely, hepatic glutathione S-transferase (GST) activity/expression increased, e.g., 3-4 fold toward 1-chloro-2,4-dinitrobenzene (total activity), up to 23-fold toward 4-vinylpyridine (rGSTP1), and approximately 7-fold for rGSTA2 protein. Dinitrochlorobenzene 105-132 hematopoietic prostaglandin D synthase Rattus norvegicus 47-50 12039566-3 2002 Introduction of the tetrazole decreases inhibitory potency towards CDNB conjugation by glutathione S-transferase. Dinitrochlorobenzene 67-71 hematopoietic prostaglandin D synthase Rattus norvegicus 87-112 12449241-5 2002 16 hr prior to sacrifice, significant decreases were observed in EROD and GST activities toward CDNB, EAA, EPNP, and CHPx, and GSH level. Dinitrochlorobenzene 96-100 hematopoietic prostaglandin D synthase Rattus norvegicus 74-77 11384612-2 2001 The activity of cytosolic GST of the cultured astrocytes toward 1-chloro-2,4-dinitrobenzene (CDNB) was much higher than that of GPx toward peroxides. Dinitrochlorobenzene 64-91 hematopoietic prostaglandin D synthase Rattus norvegicus 26-29 11384612-2 2001 The activity of cytosolic GST of the cultured astrocytes toward 1-chloro-2,4-dinitrobenzene (CDNB) was much higher than that of GPx toward peroxides. Dinitrochlorobenzene 93-97 hematopoietic prostaglandin D synthase Rattus norvegicus 26-29 11384612-5 2001 In the case of the astrocytes, a major GST isozyme with an isoelectric point (pI) of 9.02 accounted for approximately 40% of total GST activity toward CDNB, while hepatic GST isozymes showed seven peaks in the basic region. Dinitrochlorobenzene 151-155 hematopoietic prostaglandin D synthase Rattus norvegicus 39-42 11384612-5 2001 In the case of the astrocytes, a major GST isozyme with an isoelectric point (pI) of 9.02 accounted for approximately 40% of total GST activity toward CDNB, while hepatic GST isozymes showed seven peaks in the basic region. Dinitrochlorobenzene 151-155 hematopoietic prostaglandin D synthase Rattus norvegicus 131-134 11384612-5 2001 In the case of the astrocytes, a major GST isozyme with an isoelectric point (pI) of 9.02 accounted for approximately 40% of total GST activity toward CDNB, while hepatic GST isozymes showed seven peaks in the basic region. Dinitrochlorobenzene 151-155 hematopoietic prostaglandin D synthase Rattus norvegicus 131-134 11205895-4 2000 Glutathione S-transferase activity was assayed using 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene as substrates. Dinitrochlorobenzene 53-80 hematopoietic prostaglandin D synthase Rattus norvegicus 0-25 11095585-2 2000 In control rats, a significant perivenous dominance of GST proteins and activities measured by the substrates 1-chloro-2,4-dinitrobenzene (broad spectrum), 1, 2-dichloro-4-nitrobenzene (M1/M2-specific), and 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (A1/A2-specific) was found. Dinitrochlorobenzene 110-137 hematopoietic prostaglandin D synthase Rattus norvegicus 55-58