PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32590338-6 2020 Kinetic analysis revealed that the increased glucose uptake is a consequence of increased phosphorylation and intracellular trapping of [18F]FDG confirmed by an increase in HK2 protein expression and activity, but not GLUT1 activity. Fluorodeoxyglucose F18 141-144 hexokinase 2 Homo sapiens 173-176 31186081-0 2019 ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway. Fluorodeoxyglucose F18 32-50 hexokinase 2 Homo sapiens 101-104 32626532-10 2020 GLUT1 and HK2 expression in ESCA was positively correlated with 18F-FDG uptake and METTL3 status (p < 0.001). Fluorodeoxyglucose F18 64-71 hexokinase 2 Homo sapiens 10-13 32626532-11 2020 Conclusions: The high expression of METTL3 is related to the high SUVmax in ESCA, and METTL3 may increase 18F-FDG uptake by regulating GLUT1 and HK2. Fluorodeoxyglucose F18 106-113 hexokinase 2 Homo sapiens 145-148 32269845-6 2020 Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Fluorodeoxyglucose F18 185-188 hexokinase 2 Homo sapiens 161-173 32269845-6 2020 Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Fluorodeoxyglucose F18 185-188 hexokinase 2 Homo sapiens 175-178 30903198-0 2019 Low hexokinase-2 expression-associated false-negative 18F-FDG PET/CT as a potential prognostic predictor in patients with multiple myeloma. Fluorodeoxyglucose F18 54-61 hexokinase 2 Homo sapiens 4-16 30848162-7 2019 Furthermore, microPET/CT imaging exhibited a reduction of 18F-FDG uptake in tumors, corresponding to the downregulated expression of HK2 in tissues. Fluorodeoxyglucose F18 58-65 hexokinase 2 Homo sapiens 133-136 30903198-1 2019 PURPOSE: False-negative 18F-FDG PET/CT, which is associated with low hexokinase-2 (HK2) expression in multiple myeloma (MM), is a new concept that is relevant for diagnosis and treatment response assessment. Fluorodeoxyglucose F18 24-31 hexokinase 2 Homo sapiens 69-81 30903198-1 2019 PURPOSE: False-negative 18F-FDG PET/CT, which is associated with low hexokinase-2 (HK2) expression in multiple myeloma (MM), is a new concept that is relevant for diagnosis and treatment response assessment. Fluorodeoxyglucose F18 24-31 hexokinase 2 Homo sapiens 83-86 30389821-0 2019 Hexokinase-2 Expression in 11C-Methionine-Positive, 18F-FDG-Negative Multiple Myeloma. Fluorodeoxyglucose F18 52-59 hexokinase 2 Homo sapiens 0-12 27726115-10 2016 The in vivo reduction of 18F-FDG uptake was always associated with downregulation of HKII and p-PKM2 Tyr105 glycolytic proteins and upregulation of mitochondrial complexes (subunits I-IV) in excised tumors. Fluorodeoxyglucose F18 25-32 hexokinase 2 Homo sapiens 85-89 26959748-7 2016 Meanwhile, the ratio between FDG and FDOPA SUV(max) (G:D) correlated positively with HK2 (Spearman"s rho = 0.86, P < 0.0001) and negatively with DDC (rho = -0.58, P = 0.02) gene expression levels, which might suggest higher glycolytic activity and less catecholaminergic differentiation in NB tumors taking up higher FDG and lower FDOPA. Fluorodeoxyglucose F18 320-323 hexokinase 2 Homo sapiens 85-88 26959748-7 2016 Meanwhile, the ratio between FDG and FDOPA SUV(max) (G:D) correlated positively with HK2 (Spearman"s rho = 0.86, P < 0.0001) and negatively with DDC (rho = -0.58, P = 0.02) gene expression levels, which might suggest higher glycolytic activity and less catecholaminergic differentiation in NB tumors taking up higher FDG and lower FDOPA. Fluorodeoxyglucose F18 29-32 hexokinase 2 Homo sapiens 85-88 26328941-1 2015 OBJECTIVES: To investigate the relationship between FDG-PET maximum standard uptake value (SUVmax), p16, EGFR, GLUT1 and HK2 expression in head and neck squamous cell carcinomas (HNSCC). Fluorodeoxyglucose F18 52-55 hexokinase 2 Homo sapiens 121-124 26824929-0 2013 Gene Expression of Glucose Transporter 1 (GLUT1), Hexokinase 1 and Hexokinase 2 in Gastroenteropancreatic Neuroendocrine Tumors: Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation. Fluorodeoxyglucose F18 146-169 hexokinase 2 Homo sapiens 67-79 20145577-8 2010 RESULTS: In a multivariate linear regression model, GLUT-1, CD68, cathepsin K, and HK2 gene expression remained in the final model as predictive variables of FDG accumulation calculated as SUVmean (R=0.26, P<0.0001). Fluorodeoxyglucose F18 158-161 hexokinase 2 Homo sapiens 83-86 20145577-10 2010 CONCLUSION: GLUT-1, HK2, CD68, and cathepsin K remained in both multivariate models and thus provided independent information regarding FDG uptake. Fluorodeoxyglucose F18 136-139 hexokinase 2 Homo sapiens 20-23 19408578-3 2009 Thus, we investigated the relationship of FDG uptake and the expressions of glucose transporter type 1 (Glut-1), glucose transporter type 3 (Glut-3), and hexokinase II (HK-II) in R-S cells of HL. Fluorodeoxyglucose F18 42-45 hexokinase 2 Homo sapiens 169-174 20810231-0 2012 18FDG PET for grading malignancy in thymic epithelial tumors: significant differences in 18FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: preliminary study. Fluorodeoxyglucose F18 0-5 hexokinase 2 Homo sapiens 146-159 18949368-4 2008 Significant correlation was found between 18F-FDG uptake and overall expression of Glut-2 (rho=0.55, p=0.002) and HK-II (rho=0.37, p=0.04). Fluorodeoxyglucose F18 42-49 hexokinase 2 Homo sapiens 114-119