PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8816981-7	1996	In contrast, anti-insulin antibodies (IAA) were present in only 2/11 0602+ ICA+ relatives versus 47/70 in non-0602 ICA+ relatives (P < 0.01).	isocyanic acid	75-78	insulin	Homo sapiens	18-25	
16757149-8	2006	Children who subsequently developed ICA or IA-2 antibodies or clinical type 1 diabetes had higher concentrations of insulin-binding antibodies than children who remained autoantibody negative.	isocyanic acid	36-39	insulin	Homo sapiens	116-123	
10690315-1	1999	OBJECTIVE: The L-type calcium current (ICa,L) in isolated human atrial myocytes was investigated as a possible target of insulin in the regulation of cardiac function.	isocyanic acid	39-42	insulin	Homo sapiens	121-128	
10690315-4	1999	RESULTS: We found a dose-dependent stimulation of ICa,L by insulin at concentrations of 100 nM, 1 microM and 10 microM.	isocyanic acid	50-53	insulin	Homo sapiens	59-66	
10690315-5	1999	Maximum stimulation of ICa,L over basal ICa,L was 140 +/- 12% (n = 11) at 10 microM insulin.	isocyanic acid	23-26	insulin	Homo sapiens	84-91	
10690315-6	1999	The maximum conductance of ICa,L was increased by 10 microM insulin from 4.0 +/- 0.3 nS to 8.3 +/- 1.0 nS (n = 6).	isocyanic acid	27-30	insulin	Homo sapiens	60-67	
10690315-9	1999	The half-maximum stimulation of ICa,L by isoproterenol and insulin (10 microM) was reached after 31 +/- 2 s and 52 +/- 5 s, respectively.	isocyanic acid	32-35	insulin	Homo sapiens	59-66	
10226887-6	1999	Overall, 9 of 13 ICA-positive first-degree relatives responded to either proinsulin or insulin.	isocyanic acid	17-20	insulin	Homo sapiens	73-83	
10226887-6	1999	Overall, 9 of 13 ICA-positive first-degree relatives responded to either proinsulin or insulin.	isocyanic acid	17-20	insulin	Homo sapiens	76-83	
10226887-7	1999	We observed an inverse relationship between antiinsulin antibodies and T-cell responses to insulin in ICA-positive first-degree relatives but not in long-standing IDDM patients.	isocyanic acid	102-105	insulin	Homo sapiens	48-55	
10330299-7	1999	Loss of first phase insulin release to IVGTT also occurred only in those ICA-positive relatives who had one or more of the other autoantibodies.	isocyanic acid	73-76	insulin	Homo sapiens	20-27	
9893097-10	1998	The positive predictive values for insulin treatment of ICA positivity, low fasting C- peptide, and low BMI were 90, 78 and 73%, respectively.	isocyanic acid	56-59	insulin	Homo sapiens	35-42	
9893097-15	1998	ICA and fasting serum C-peptide facilitate the choice of insulin treatment, but cost is a limit to large-scale use of these tests.	isocyanic acid	0-3	insulin	Homo sapiens	57-64	
1505333-6	1992	There was a significant negative correlation between ICA titers and C-peptide at 18 and 24 mo after diagnosis (P = 0.04).	isocyanic acid	53-56	insulin	Homo sapiens	68-77	
7859592-8	1994	A surprising result is that this gene mutation is often observed in ICA-positive IDDM patients who were initially non-insulin-dependent, so called slowly progressive IDDM patients.	isocyanic acid	68-71	insulin	Homo sapiens	118-125	
8001710-3	1994	The number of individuals necessary to be included in these trials will be function of the therapeutic goals and on the efficacy of the drug in pilot studies in high risk individuals, namely ICA positive subjects with low first phase insulin release during IVGTT.	isocyanic acid	191-194	insulin	Homo sapiens	234-241	
2226121-2	1990	ICA were found in three (8.6%) IDDM patients and five (6.8%) insulin-requiring NIDDM patients; six of the eight were also CF-ICA positive.	isocyanic acid	0-3	insulin	Homo sapiens	61-68	
1516482-5	1992	Islet cell antibody positive (ICA+) IDDM relatives had significantly higher proinsulin levels than ICA- (16 pM; range 7.2-25 vs. 6.9 pM, range 3.1-12 pM; P = 0.02).	isocyanic acid	30-33	insulin	Homo sapiens	76-86	
1516482-9	1992	Because proinsulin is more elevated in ICA+ than in ICA- subjects, increased proinsulin levels could reflect minor beta-cell damage due to previous immunological attack.	isocyanic acid	39-42	insulin	Homo sapiens	8-18	
1516482-9	1992	Because proinsulin is more elevated in ICA+ than in ICA- subjects, increased proinsulin levels could reflect minor beta-cell damage due to previous immunological attack.	isocyanic acid	39-42	insulin	Homo sapiens	77-87	
1516482-9	1992	Because proinsulin is more elevated in ICA+ than in ICA- subjects, increased proinsulin levels could reflect minor beta-cell damage due to previous immunological attack.	isocyanic acid	52-55	insulin	Homo sapiens	77-87	
3072142-3	1988	Only one remission has been detected in ICA positive group (insulin requirement less than 0.25 U/Kg), while four ICA negative patients had complete remission and three had partial remission.	isocyanic acid	40-43	insulin	Homo sapiens	60-67	
3072142-6	1988	Our study suggests that presence and persistence of ICA may be considered an early and predictive marker for a worse beta cell function restoration resulting in a higher insulin requirement.	isocyanic acid	52-55	insulin	Homo sapiens	170-177	
3071483-8	1988	Half of the ICA positive relatives were also found insulin autoantibodies (IAA) positive.	isocyanic acid	12-15	insulin	Homo sapiens	51-58	
3277828-3	1988	During the first year after diagnosis the only significant finding was that in ICA (+) patients insulin dose (units/kg) was lower at both 6 and 12 months (mean +/- SD 0.55 +/- 0.14 and 0.67 +/- 0.12 U/kg, respectively) than ICA (-)"s (0.70 +/- 0.22 and 0.96 +/- 0.38, respectively, both P less than 0.05).	isocyanic acid	79-82	insulin	Homo sapiens	96-103	
6395671-17	1984	Older type II diabetic humans with ICA usually proceed to insulin therapy more rapidly than do those who are ICA negative (Irvine et al., 1977; Del Prete et al., 1977; Gray et al., 1980).	isocyanic acid	35-38	insulin	Homo sapiens	58-65