PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25998402-0	2015	Thiopurine Resistance in Childhood ALL Is Mediated by PRPS1 Mutations.	2-mercaptopyrazine	0-10	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	54-59	
25998402-1	2015	Mutations in the de novo purine biosynthesis enzyme PRPS1 drive thiopurine resistance in relapsed ALL.	2-mercaptopyrazine	64-74	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	52-57	
34636169-0	2021	NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.	2-mercaptopyrazine	60-70	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	34-39	
25962120-0	2015	Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.	2-mercaptopyrazine	48-58	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	28-33	
25962120-5	2015	Our functional analyses of PRPS1 mutants uncovered a new chemotherapy-resistance mechanism involving reduced feedback inhibition of de novo purine biosynthesis and competitive inhibition of thiopurine activation.	2-mercaptopyrazine	190-200	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	27-32	
34636169-3	2021	It has also been demonstrated that acquired somatic mutations of the NT5C2 and PRPS1 genes, which are involved in thiopurine metabolism, are detectable in a portion of relapsed childhood ALL.	2-mercaptopyrazine	114-124	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	79-84	
32391636-0	2020	Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt"s lymphoma.	2-mercaptopyrazine	49-59	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	33-40	
32391636-5	2020	PRPS2 homologous isoenzyme, PRPS1, was demonstrated to play the main role in thiopurine resistance.	2-mercaptopyrazine	77-87	phosphoribosyl pyrophosphate synthetase 1	Homo sapiens	28-33