PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26015807-11 2015 It also revealed overexpression of the ATM/p53/p21 pathway, which is activated in response to DNA damage and induces cell cycle arrest in thiopurine resistant LCLs. 2-mercaptopyrazine 138-148 tumor protein p53 Homo sapiens 43-46 26015807-12 2015 Furthermore, overexpression of the p53 target gene TNFRSF10D or the negative cell cycle regulator CCNG2 induces cell cycle arrest and may also contribute to thiopurine resistance. 2-mercaptopyrazine 157-167 tumor protein p53 Homo sapiens 35-38 34483003-5 2022 Furthermore, therapy-induced mutational signatures implicated in cancer progression have also been uncovered, including the identification of thiopurine-induced TP53 mutations in leukemia. 2-mercaptopyrazine 142-152 tumor protein p53 Homo sapiens 161-165