PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34636169-0	2021	NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.	2-mercaptopyrazine	60-70	5'-nucleotidase, cytosolic II	Homo sapiens	24-29	
34636169-3	2021	It has also been demonstrated that acquired somatic mutations of the NT5C2 and PRPS1 genes, which are involved in thiopurine metabolism, are detectable in a portion of relapsed childhood ALL.	2-mercaptopyrazine	114-124	5'-nucleotidase, cytosolic II	Homo sapiens	69-74	
33124053-9	2021	Our results indicated that NT5C2 germline variation significantly contributes to inter-patient variability in thiopurine drug disposition.	2-mercaptopyrazine	110-120	5'-nucleotidase, cytosolic II	Homo sapiens	27-32	
31358663-0	2019	Mechanisms of NT5C2-mediated thiopurine resistance in acute lymphoblastic leukemia.	2-mercaptopyrazine	29-39	5'-nucleotidase, cytosolic II	Homo sapiens	14-19	
31358663-2	2019	Recently, recurrent mutations in NT5C2 were identified as a common genomic lesion unique in relapsed ALL and were linked to acquired thiopurine resistance.	2-mercaptopyrazine	133-143	5'-nucleotidase, cytosolic II	Homo sapiens	33-38	
31358663-3	2019	However, molecular mechanisms by which NT5C2 regulates thiopurine cytotoxicity were incompletely understood.	2-mercaptopyrazine	55-65	5'-nucleotidase, cytosolic II	Homo sapiens	39-44	
31358663-5	2019	Compared to wildtype NT5C2, mutant proteins showed elevated 5"-nucleotidase activity with a stark preference of thiopurine metabolites over endogenous purine nucleotides, suggesting neomorphic effects specific to thiopurine metabolism.	2-mercaptopyrazine	112-122	5'-nucleotidase, cytosolic II	Homo sapiens	21-26	
31358663-5	2019	Compared to wildtype NT5C2, mutant proteins showed elevated 5"-nucleotidase activity with a stark preference of thiopurine metabolites over endogenous purine nucleotides, suggesting neomorphic effects specific to thiopurine metabolism.	2-mercaptopyrazine	213-223	5'-nucleotidase, cytosolic II	Homo sapiens	21-26	
31358663-6	2019	Expression of mutant NT5C2 mutations also significantly reduced thiopurine uptake in vitro with concomitant increase in efflux of MP metabolites, plausibly via indirect effects on drug transporter pathways.	2-mercaptopyrazine	64-74	5'-nucleotidase, cytosolic II	Homo sapiens	21-26	
31358663-8	2019	Collectively, our data indicated that NT5C2 mutations alter thiopurine metabolism and cellular disposition, but also influenced endogenous nucleotide homeostasis and thiopurine-induced metabolomic response.	2-mercaptopyrazine	60-70	5'-nucleotidase, cytosolic II	Homo sapiens	38-43	
31358663-8	2019	Collectively, our data indicated that NT5C2 mutations alter thiopurine metabolism and cellular disposition, but also influenced endogenous nucleotide homeostasis and thiopurine-induced metabolomic response.	2-mercaptopyrazine	166-176	5'-nucleotidase, cytosolic II	Homo sapiens	38-43	
30201983-0	2018	NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.	2-mercaptopyrazine	30-40	5'-nucleotidase, cytosolic II	Homo sapiens	0-5	
29990496-0	2018	Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.	2-mercaptopyrazine	52-62	5'-nucleotidase, cytosolic II	Homo sapiens	28-33	
30910786-1	2019	Mutations in the cytosolic 5" nucleotidase II (NT5C2) gene drive resistance to thiopurine chemotherapy in relapsed acute lymphoblastic leukemia (ALL).	2-mercaptopyrazine	79-89	5'-nucleotidase, cytosolic II	Homo sapiens	47-52