PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19308286-0	2009	Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment.	Depsipeptides	111-123	BCL2 like 11	Homo sapiens	31-34	
19308286-4	2009	Further study showed that Bim, a BH3-only proapoptotic protein, was significantly upregulated by depsipeptide in cancer cells, and Bim"s function in depsipeptide-induced apoptosis was confirmed by knockdown of Bim with RNAi.	Depsipeptides	97-109	BCL2 like 11	Homo sapiens	26-29	
19308286-5	2009	In addition, we found that depsipeptide-induced expression of Bim was directly dependent on acetylation of forkhead box class O1 (FoxO1) that is catalyzed by cyclic adenosine monophosphate-responsive element-binding protein-binding protein, and indirectly induced by a decreased four-and-a-half LIM-domain protein 2.	Depsipeptides	27-39	BCL2 like 11	Homo sapiens	62-65	
19308286-6	2009	Moreover, our results demonstrated that FoxO1 acetylation is required for the depsipeptide-induced activation of Bim and apoptosis, using transfection with a plasmid containing FoxO1 mutated at lysine sites and a luciferase reporter assay.	Depsipeptides	78-90	BCL2 like 11	Homo sapiens	113-116