PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20811699-2	2010	The present study showed that the histone deacetylase (HDAC) inhibitors valproic acid (VPA) and depsipeptide (FK228) synergistically enhanced ionizing radiation (IR)-induced apoptosis, associated with activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase in Y79 and WER1-Rb1 human retinoblastoma cells.	Depsipeptides	96-108	caspase 3	Homo sapiens	215-224	
27509880-0	2016	Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.	Depsipeptides	49-61	caspase 3	Homo sapiens	163-174	
27509880-3	2016	Exposure to a combination of 5-FU (1.75 microM) and 1 nM depsipeptide for 24 and 48 h resulted in a 3- to 4-fold increase in activated caspase-3/7, while 5-FU alone failed to activate caspase-3/7.	Depsipeptides	57-69	caspase 3	Homo sapiens	135-144	
27509880-3	2016	Exposure to a combination of 5-FU (1.75 microM) and 1 nM depsipeptide for 24 and 48 h resulted in a 3- to 4-fold increase in activated caspase-3/7, while 5-FU alone failed to activate caspase-3/7.	Depsipeptides	57-69	caspase 3	Homo sapiens	135-146	
15515013-5	2005	Depsipeptide activated caspases-8 and -10, which in turn cleave caspases-3 and -7, leading to apoptotic cell death in both cell lines.	Depsipeptides	0-12	caspase 3	Homo sapiens	64-81	
15467034-11	2004	Depsipeptide-mediated apoptosis was associated with a 12-fold increased level of active caspase 3, but some apoptosis persisted despite z-VAD-fmk treatment to inhibit caspase activity.	Depsipeptides	0-12	caspase 3	Homo sapiens	88-97