PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29960296-4	2017	RESULTS: In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 mumol/L baicalinfor 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed thatbaicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometricanalysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the mRNA andprotein level.	baicalin	91-99	caspase 3	Homo sapiens	437-446	
26688183-7	2016	Western blot and real-time PCR analysis revealed that significant decrease in caspase-3 expression in the baicalin group compared with the OGD/RO group (P<0.01).	baicalin	106-114	caspase 3	Homo sapiens	78-87	
26309548-6	2015	Moreover, baicalin induced apoptotic cell death in Hep G2 and SMMC-7721 cells, which was accompanied by upregulation of Bax, downregulation of Bcl-2, and cleavages of Caspase-9, Caspase-3, and PARP.	baicalin	10-18	caspase 3	Homo sapiens	178-187	
22607709-7	2012	CA46 cells underwent apoptosis in response to baicalin treatment as evidenced by an increase in the percentage of cells stainable with Annexin V, by increased DNA fragmentation, and by activation of the intrinsic (mitochondrial) pathway for cell death as characterized by increased expression of the cleaved forms of caspase-9, caspase-3, and poly (ADP-ribose) polymerase.	baicalin	46-54	caspase 3	Homo sapiens	328-337	
25561931-7	2015	These results indicated that baicalin-induced apoptosis involved activation Caspase-3 in HeLa cells through the intracellular mitochondrial pathway and the surface death receptor pathway.	baicalin	29-37	caspase 3	Homo sapiens	76-85	
25694047-7	2015	Furthermore, baicalin-copper treatment significantly increased the Bax/Bcl-2 ratio and p38 levels, as well as decreased the expression of caspase-3, p-PI3K, p-Akt and p-mTOR (P < 0.01).	baicalin	13-21	caspase 3	Homo sapiens	138-147	
31223113-6	2019	Baicalin (200 mug/mL) significantly promoted the apoptosis of keratinocytes, arrested the S phase, inhibited the mRNA expression of ki67, increased the Fas and caspase-3 levels, down-regulated the protein expression of Jagged 1, and up-regulated the Notch 1 and Hes protein levels.	baicalin	0-8	caspase 3	Homo sapiens	160-169	
17352223-4	2007	The results showed that baicalin induced cytotoxicity in a dose- and time-dependent manner through the activation of caspase-3, as shown by treatment of HL-60 cells with an inhibitor of caspase-3 (z-VAD-fmk).	baicalin	24-32	caspase 3	Homo sapiens	117-126	
17352223-4	2007	The results showed that baicalin induced cytotoxicity in a dose- and time-dependent manner through the activation of caspase-3, as shown by treatment of HL-60 cells with an inhibitor of caspase-3 (z-VAD-fmk).	baicalin	24-32	caspase 3	Homo sapiens	186-195	
17352223-6	2007	Western blot demonstrated that baicalin promoted the levels of Gadd153, Bax, cytochrome c and caspase-3 and -12, but decreased the levels of Grp78 and Bcl-2 in HL-60 cells.	baicalin	31-39	caspase 3	Homo sapiens	94-111	
11053652-7	2000	The inhibition of proliferation of prostate cancer cells after a short period of exposure to baicalin was associated with induction by apoptosis, as evidenced by the typical nuclear fragmentation using Hoechst 33258 staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) labeling, DNA fragmentation, activation of caspase-3 and cleavage of poly-ADP-ribose polymerase (PARP).	baicalin	93-101	caspase 3	Homo sapiens	347-356	
35350754-9	2022	Result: A total of 86 overlapping targets of baicalin and CS were identified, among which MAPK14, IL2, FGF2, CASP3, PTGS2, PIK3CA, EGFR, and TNF were the core targets.	baicalin	45-53	caspase 3	Homo sapiens	109-114	
35573641-5	2022	Baicalin-induced apoptosis was confirmed by enhanced Bax, cleaved caspase-3, and cleaved PARP levels and decreased Bcl-2 levels.	baicalin	0-8	caspase 3	Homo sapiens	66-75	
32278854-10	2020	The anti-obesity effects of baicalin might be due to the up-regulation of solute carrier family 2 member 1 (SLC2A1) and down-regulation of tumor necrosis factor (TNF), nuclear factor kappa B subunit 1 (NFKB1), sterol regulatory element binding transcription factor 1 (SREBF1), peroxisome proliferator activated receptor gamma and caspase 3 (CASP3).	baicalin	28-36	caspase 3	Homo sapiens	330-339	
32278854-10	2020	The anti-obesity effects of baicalin might be due to the up-regulation of solute carrier family 2 member 1 (SLC2A1) and down-regulation of tumor necrosis factor (TNF), nuclear factor kappa B subunit 1 (NFKB1), sterol regulatory element binding transcription factor 1 (SREBF1), peroxisome proliferator activated receptor gamma and caspase 3 (CASP3).	baicalin	28-36	caspase 3	Homo sapiens	341-346	
31607304-14	2019	CONCLUSION: Baicalin derivative 02-036 can effectively inhibit the proliferation and induce apoptosis of CA46 cells, and its related mechanisms may be correlated with the down-regulation of apoptosis-related molecule expression levels, such as BCL-2, Pro-caspase-9, Pro-caspase-3, PARP and C-MYC.	baicalin	12-20	caspase 3	Homo sapiens	266-279	
22121772-8	2011	The further mechanism studies show that baicalin inhibit apoptosis via reducing Caspase-3 expression and up-regulating SIRT1.	baicalin	40-48	caspase 3	Homo sapiens	80-89	
16552836-8	2006	Baicalin (37.5 microg/ml) also elevated the amount of cytosolic cytochrome c (19.2 microg/ml), which finally triggered the activation of caspase-3 (50.1 pmol/min).	baicalin	0-8	caspase 3	Homo sapiens	137-146	
11841838-5	2002	Induction of apoptosis by baicalin was accompanied with the marginal generation of intracellular reactive oxygen species (ROS), the increase of the cytosolic fractions of cytochrome c, and the disruption of mitochondrial transmembrane potential (DeltaPsi(m)) prior to the activation of caspase-3.	baicalin	26-34	caspase 3	Homo sapiens	286-295	
31881375-8	2020	Baicalin inhibited cell proliferation, arrested the cell cycle at the G0/G1 phase, and induced cell death through caspase 3/7 activation.	baicalin	0-8	caspase 3	Homo sapiens	114-125