PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29168506-5 2017 Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. Oxygen 45-51 NFS1 cysteine desulfurase Homo sapiens 91-95 1510191-2 1992 Inhalation of 50% oxygen in patients who were not in crisis produced a significant fall in RSCs and a lesser fall in ISCs. Oxygen 18-24 NFS1 cysteine desulfurase Homo sapiens 117-121 29168506-6 2017 NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Oxygen 144-150 NFS1 cysteine desulfurase Homo sapiens 0-4 29168506-3 2017 Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. Oxygen 15-21 NFS1 cysteine desulfurase Homo sapiens 156-160