PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34385713-3 2021 Mechanistically, autoantibodies and interferon-alpha present in the serum induce neutrophil ferroptosis through enhanced binding of the transcriptional repressor CREMalpha to the glutathione peroxidase 4 (Gpx4, the key ferroptosis regulator) promoter, which leads to suppressed expression of Gpx4 and subsequent elevation of lipid-reactive oxygen species. Oxygen 340-346 interferon alpha Mus musculus 36-52 31732720-6 2020 Furthermore, STAT1 phosphorylation and pathway activation is greater after IFN-alpha stimulation in Jak2V617F murine HSCs with increased induction of reactive oxygen species, DNA damage and reduction in quiescence after chronic IFN-alpha treatment. Oxygen 159-165 interferon alpha Mus musculus 75-84 10747889-5 2000 If a comparable interaction occurs in catalysis, then Gln(382) may provide electrostatic stabilization of partial negative charge on the epoxide oxygen. Oxygen 145-151 interferon alpha Mus musculus 0-4 6330202-5 1984 In fact, impairment of M phi suppression by IFN-alpha occurred in parallel to the decrease of M phi capacity to produce PGE2 and the oxygen intermediate O2-, two molecules responsible for M phi-suppressive activity. Oxygen 133-139 interferon alpha Mus musculus 44-53 6330202-5 1984 In fact, impairment of M phi suppression by IFN-alpha occurred in parallel to the decrease of M phi capacity to produce PGE2 and the oxygen intermediate O2-, two molecules responsible for M phi-suppressive activity. Oxygen 153-155 interferon alpha Mus musculus 44-53