PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33328510-4 2020 In this study, we demonstrate that the expressions of HOTAIRM1 and its target HOXA1 are substantially upregulated to promote the expressions of immunosuppressive molecules, including arginase 1, inducible nitric oxide synthase, signal transducer and activator of transcription 3, and reactive oxygen species, in CD33+ myeloid cells derived from hepatitis C virus (HCV)-infected patients. Oxygen 293-299 CD33 molecule Homo sapiens 312-316 29950247-2 2018 The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS. Oxygen 107-113 CD33 molecule Homo sapiens 58-62 24504963-1 2014 The superoxide (O2 ( -))-generating NADPH oxidase complex of phagocytes comprises a membrane-imbedded heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of Nox2 and p22 (phox) ) and four cytosolic regulatory proteins, p47 (phox) , p67 (phox) , p40 (phox) , and the small GTPase Rac. Oxygen 16-18 CD33 molecule Homo sapiens 249-252 9131041-1 1997 The superoxide (O2-)-generating NADPH oxidase of phagocytic cells is composed of a membrane-bound flavocytochrome (cytochrome b-559) and three cytosolic components, p47-phox, p67-phox, and the small GTPase rac-1 (or 2). Oxygen 16-18 CD33 molecule Homo sapiens 175-178 21954286-7 2012 p67(phox) is involved in the regulation of electron flow from NADPH to oxygen, leading to superoxide radical formation inside the phagosome. Oxygen 71-77 CD33 molecule Homo sapiens 0-3 20679349-2 2010 The membrane-integrated protein gp91(phox) serves as the catalytic core, because it contains a complete electron-transporting apparatus from NADPH to molecular oxygen for superoxide production. Oxygen 160-166 CD33 molecule Homo sapiens 37-41 12483106-2 2003 Rac-GTP is a component of the membrane-assembled NADPH oxidase complex, and new evidence suggests that Rac-GTP interacts directly with the oxidase flavocytochrome, in addition to binding to the regulatory p67 subunit, to regulate electron transfer both independently and cooperatively from NADPH to molecular oxygen. Oxygen 309-315 CD33 molecule Homo sapiens 205-208 10438466-1 1999 An activation domain in p67(phox) (residues within 199-210) is essential for cytochrome b(558)-dependent activation of NADPH superoxide (O2(-.)) Oxygen 137-139 CD33 molecule Homo sapiens 24-27 10438466-1 1999 An activation domain in p67(phox) (residues within 199-210) is essential for cytochrome b(558)-dependent activation of NADPH superoxide (O2(-.)) Oxygen 137-139 CD33 molecule Homo sapiens 28-32 10438466-8 1999 The activation domain on p67(phox) was critical for regulating flavin reduction, since mutations in this region that decreased O2(-.) Oxygen 127-129 CD33 molecule Homo sapiens 25-28 10438466-8 1999 The activation domain on p67(phox) was critical for regulating flavin reduction, since mutations in this region that decreased O2(-.) Oxygen 127-129 CD33 molecule Homo sapiens 29-33 17969555-15 2007 Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-. Oxygen 192-198 CD33 molecule Homo sapiens 11-14 17969555-15 2007 Binding of p67-phox to cytochrome b558 induces a gradual conformational change of cytochrome b558, which then becomes capable of transferring electrons produced in the cytoplasm from NADPH to oxygen, reducing the latter to O2-. Oxygen 223-225 CD33 molecule Homo sapiens 11-14 8608803-6 1996 This system is characterized by the partial reconstitution of O-(2) production in an Epstein-Barr virus (EBV)-transformed lymphoblastoid B cell line from a patient with p67-phox-deficient CGD by transfection with an expression plasmid containing the 67-phox cDNA in the sense orientation. Oxygen 62-67 CD33 molecule Homo sapiens 169-172 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. Oxygen 115-121 CD33 molecule Homo sapiens 25-29 35625671-9 2022 The expression levels of CD33+ leukocytes and circulating IL-6 were higher (p < 0.05) among patients with arterial oxygen partial pressure-to-fractional inspired oxygen (PaO2/FiO2) ratios below 13.3 kPa compared to in the remaining patients. Oxygen 162-168 CD33 molecule Homo sapiens 25-29