PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1757301-0 1991 Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity. Oxygen 16-18 monoamine oxidase A Rattus norvegicus 33-50 8462004-5 1993 In this study, rats treated with an MAO inhibitor (pargyline) or a nitric oxide synthase inhibitor (LNNA) were protected against O2-induced convulsions. Oxygen 129-131 monoamine oxidase A Rattus norvegicus 36-39 21377526-6 2011 Clorgyline, an inhibitor of MAO-A, markedly decreases the formation of reactive oxygen species in PC12 cells upon dopamine exposure but has only mild protective actions against quinoprotein adduct formation, mitochondrial dysfunctions, cell death and caspase activation induced by dopamine. Oxygen 80-86 monoamine oxidase A Rattus norvegicus 28-33 1757301-3 1991 We investigated the relationship between regional generation of hydrogen peroxide (H2O2) in the brain in the presence of an irreversible inhibitor of catalase, aminotriazole (ATZ), and protection from CNS O2 toxicity by a monoamine oxidase (MAO) inhibitor, pargyline. Oxygen 85-87 monoamine oxidase A Rattus norvegicus 222-239 1757301-8 1991 These findings indicate that H2O2 generated by MAO during hyperoxia is important to the pathogenesis of CNS O2 toxicity in rats. Oxygen 31-33 monoamine oxidase A Rattus norvegicus 47-50 3999927-5 1985 MAO was assayed by measuring the rate of oxygen consumption in a small cell with a Clark electrode. Oxygen 41-47 monoamine oxidase A Rattus norvegicus 0-3 2720154-2 1989 It was shown that in rat brain MAO"s affinity for serotonin reduced from the 5th minute of exposure to hyperbaric oxygen and went on reducing on the 15th minute. Oxygen 114-120 monoamine oxidase A Rattus norvegicus 31-34 3676473-1 1987 The reversible MAO-A inhibitor moclobemide (5 mg/kg) was shown to prevent seizures in rats during exposure to toxic oxygen (6 ata). Oxygen 116-122 monoamine oxidase A Rattus norvegicus 15-20 3676473-6 1987 The possibility is shown to prevent oxygen seizures not only with irreversible MAO-A inhibitors (clorgyline), but also with reversible ones (moclobemide). Oxygen 36-42 monoamine oxidase A Rattus norvegicus 79-84 3801652-1 1987 Administration of monoamine oxidase type A inhibitor clorgyline to rats before hyperoxia prevented oxygen-induced increase in diene conjugate and Shiff"s base brain and plasma levels in hyperoxia. Oxygen 99-105 monoamine oxidase A Rattus norvegicus 18-42 3727040-2 1986 A preliminary injection of clorgyline (a monoamine oxidase type A inhibitor) before hyperoxic exposure leads to a significant removal of oxygen seizures and prevents changes in the cerebral spermidine and histamine content observed in the unprotected animals. Oxygen 137-143 monoamine oxidase A Rattus norvegicus 41-65 6518192-4 1984 In experiments with membrane-bound and partially purified MAO, the Km and V values were shown to increase non-competitively with a rise in O2 concentration. Oxygen 139-141 monoamine oxidase A Rattus norvegicus 58-61 6518192-5 1984 In contrast with intact mitochondria, the use of partially purified MAO preparations led to a loss of the enzyme sensitivity to O2 depending on the nature of the amine. Oxygen 128-130 monoamine oxidase A Rattus norvegicus 68-71 452501-1 1979 Substrate specificity of monoamine oxidase (MAO) of the A type from rat brain and liver tissues was altered after exposure of rats to an increased oxygen pressure [4 ati O2, 1 hr]. Oxygen 147-153 monoamine oxidase A Rattus norvegicus 25-42 6441605-1 1984 Monoamine oxidase type A activity with substrate serotonine and type B with substrate p-nitrophenylethylamine decreases is rats" brain, liver, heart and blood during oxygen convulsions. Oxygen 166-172 monoamine oxidase A Rattus norvegicus 0-24 452501-1 1979 Substrate specificity of monoamine oxidase (MAO) of the A type from rat brain and liver tissues was altered after exposure of rats to an increased oxygen pressure [4 ati O2, 1 hr]. Oxygen 147-153 monoamine oxidase A Rattus norvegicus 44-47 452501-4 1979 Alterations in catalytic properties of MAO of the A type were apparently important in development of the oxygen intoxication. Oxygen 105-111 monoamine oxidase A Rattus norvegicus 39-42 21126-2 1977 MAO activity in rat brain mitochondria with tyramine as substrate at 100% oxygen concentration was three times as much as that at 20%. Oxygen 74-80 monoamine oxidase A Rattus norvegicus 0-3