PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23065129-8	2013	Furthermore, the oxygen sensor hypoxia-inducible factor (HIF)-1/2alpha and the angiogenic factor vascular endothelial growth factor (VEGF) were highly expressed in the lungs of sildenafil-treated rats.	Oxygen	17-23	endothelial PAS domain protein 1	Rattus norvegicus	31-70	
23962064-8	2014	In experimental O2-induced arrested alveolar growth in newborn rats, the characteristic features of air space enlargement and loss of lung capillaries were associated with decreased lung HIF-1alpha and HIF-2alpha expression.	Oxygen	16-18	endothelial PAS domain protein 1	Rattus norvegicus	202-212	
18353899-0	2008	Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.	Oxygen	54-56	endothelial PAS domain protein 1	Rattus norvegicus	13-23	
21753061-8	2011	Taken together, these results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of IRP in response to dietary iron deficiency and provide evidence that IRP may assist in coordinating the cellular response to alterations in iron and oxygen status associated with iron deficiency anemia.	Oxygen	273-279	endothelial PAS domain protein 1	Rattus norvegicus	62-72	
18353899-0	2008	Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.	Oxygen	75-77	endothelial PAS domain protein 1	Rattus norvegicus	13-23	
18353899-3	2008	To address this, we monitored HIF-2alpha expression and oxygen consumption in an O2-sensitive immortalized rat adrenomedullary chromaffin (MAH) cell line.	Oxygen	81-83	endothelial PAS domain protein 1	Rattus norvegicus	30-40	
18353899-4	2008	Hypoxia (2-8% O2) caused a concentration- and time-dependent increase in HIF-2alpha induction, which was blocked in MAH cells with either RNA interference knockdown of the Rieske Fe-S protein, a component of complex III, or knockdown of cytochrome-c oxidase subunit of complex IV, or defective mitochondrial DNA (rho0 cells).	Oxygen	14-16	endothelial PAS domain protein 1	Rattus norvegicus	73-83	
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	88-90	endothelial PAS domain protein 1	Rattus norvegicus	154-164	
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	149-151	endothelial PAS domain protein 1	Rattus norvegicus	154-164	
18353899-6	2008	Interestingly, the inhibitory effects of the mitochondrial inhibitors were dependent on O2 concentration such that at moderate-to-severe hypoxia (6% O2), HIF-2alpha induction was blocked by low inhibitor concentrations that were ineffective at more severe hypoxia (2% O2).	Oxygen	149-151	endothelial PAS domain protein 1	Rattus norvegicus	154-164	
18353899-8	2008	These data suggest that in this O2-sensitive cell line, mitochondrial O2 consumption, rather than changes in ROS, regulates HIF-2alpha during hypoxia.	Oxygen	32-34	endothelial PAS domain protein 1	Rattus norvegicus	124-134	
18353899-8	2008	These data suggest that in this O2-sensitive cell line, mitochondrial O2 consumption, rather than changes in ROS, regulates HIF-2alpha during hypoxia.	Oxygen	70-72	endothelial PAS domain protein 1	Rattus norvegicus	124-134	
12805361-13	2003	Hence, in PC12 cells the level of HIF-2 alpha protein and its effect on gene expression can be down-regulated by stimuli other than oxygen.	Oxygen	132-138	endothelial PAS domain protein 1	Rattus norvegicus	34-45	
15879294-4	2005	We have investigated the possibility that the hypoxia-inducible factors HIF-1alpha and HIF-2alpha, which are activated by oxygen deprivation, are involved in this resetting process.	Oxygen	122-128	endothelial PAS domain protein 1	Rattus norvegicus	87-97	
15879294-9	2005	After exposure to hypoxia (8% O(2), 6 h), the expression of HIF-1alpha was selectively up-regulated in glomus cells and apparent translocation of both HIF-1alpha and HIF-2alpha to the nucleus was observed.	Oxygen	30-34	endothelial PAS domain protein 1	Rattus norvegicus	166-176	
12490539-3	2003	Their regulation occurs through oxygen-dependent proteolysis of the alpha subunits HIF-1alpha and HIF-2alpha, respectively.	Oxygen	32-38	endothelial PAS domain protein 1	Rattus norvegicus	98-108	
12089367-10	2002	The kidney demonstrates a marked potential for upregulation of HIF, but accumulation of HIF-1alpha and HIF-2alpha is selective with respect to cell type, kidney zone, and experimental conditions, with the expression patterns partly matching known oxygen profiles.	Oxygen	247-253	endothelial PAS domain protein 1	Rattus norvegicus	103-113