PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19448429-5 2009 Low oxygen levels result in strongly increased HIPK2/Siah2 interactions that lead to efficient polyubiquitylation and proteasomal degradation of the kinase. Oxygen 4-10 homeodomain interacting protein kinase 2 Homo sapiens 47-52 31837296-5 2020 HIPK2 depletion by small interfering RNA (siRNA)-mediated gene silencing significantly decreased the viability and exacerbated H/R-induced apoptosis and reactive oxygen species (ROS) production in cardiomyocytes. Oxygen 162-168 homeodomain interacting protein kinase 2 Homo sapiens 0-5 19714248-5 2009 METHODOLOGY/PRINCIPAL FINDINGS: Upon exposure of colon and lung cancer cells to hypoxia, by either low oxygen or cobalt, HIPK2 function was impaired allowing for increased HIF-1alpha expression and inhibiting the p53-apoptotic response to drug. Oxygen 103-109 homeodomain interacting protein kinase 2 Homo sapiens 121-126