PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31983610-2 2020 Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Oxygen 77-83 TP53 induced glycolysis regulatory phosphatase Homo sapiens 112-117 30814486-10 2019 TIGAR can decrease lactate production and accelerate oxygen consumption and ATP generation to maintain a high rate of OXPHOS in differentiated NSCs. Oxygen 53-59 TP53 induced glycolysis regulatory phosphatase Homo sapiens 0-5 31799200-13 2019 TIGAR knockdown led to increased ROS production, elevated mitochondrial ATP production, and phosphorus oxygen ratios. Oxygen 92-109 TP53 induced glycolysis regulatory phosphatase Homo sapiens 0-5 27803158-6 2016 Carcinoma cells overexpressing TIGAR have higher oxygen consumption rates and ATP levels when exposed to glutamine, lactate, or the combination of glutamine and lactate. Oxygen 49-55 TP53 induced glycolysis regulatory phosphatase Homo sapiens 31-36 22887998-4 2012 We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell death induced by glucose and oxygen restriction. Oxygen 139-145 TP53 induced glycolysis regulatory phosphatase Homo sapiens 20-25 22887998-4 2012 We demonstrate that TIGAR is overexpressed in glioblastomas and that ectopic expression of TIGAR reduces cell death induced by glucose and oxygen restriction. Oxygen 139-145 TP53 induced glycolysis regulatory phosphatase Homo sapiens 91-96 34583309-1 2021 TP53 (tumor protein 53)-induced glycolysis and apoptosis regulator (TIGAR) belongs to the phosphatases family of proteins that modulates the level of reactive oxygen species in tumor cells. Oxygen 159-165 TP53 induced glycolysis regulatory phosphatase Homo sapiens 68-73