PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20130271-7	2010	Accumulation of HBEGF at reduced oxygen was blocked only by a combination of U0126, SB203580, and SP600125.	Oxygen	33-39	heparin binding EGF like growth factor	Homo sapiens	16-21	
27701455-1	2016	INTRODUCTION: The growth factor HBEGF is upregulated post-transcriptionally in the low O2 environment of the human placenta during the first 10 weeks of pregnancy.	Oxygen	87-89	heparin binding EGF like growth factor	Homo sapiens	32-37	
27701455-2	2016	We have examined the possible roles of HBEGF turnover and micro-RNA (miRNA) in its regulation by O2 in human first trimester trophoblast.	Oxygen	97-99	heparin binding EGF like growth factor	Homo sapiens	39-44	
27701455-8	2016	RESULTS: Protein turnover studies, using 10 mug/ml cyclohexamide, 1 mug/ml lactocystin, or 100 mug/ml MG132, demonstrated faster HBEGF degradation at 20% O2 than 2% O2, mediated by the proteasome.	Oxygen	154-156	heparin binding EGF like growth factor	Homo sapiens	129-134	
27701455-8	2016	RESULTS: Protein turnover studies, using 10 mug/ml cyclohexamide, 1 mug/ml lactocystin, or 100 mug/ml MG132, demonstrated faster HBEGF degradation at 20% O2 than 2% O2, mediated by the proteasome.	Oxygen	165-167	heparin binding EGF like growth factor	Homo sapiens	129-134	
27701455-12	2016	Nevertheless, HBEGF upregulation at 2% O2 was blocked when the miRNA-processing protein DGCR8 was silenced, suggesting a role for miRNA.	Oxygen	39-41	heparin binding EGF like growth factor	Homo sapiens	14-19	
29191924-7	2018	Moreover, the expressions of HB-EGF and VEGF were increased after laser-induced CNV and oxygen-induced retinopathy, and their expression sites were located around the neovascular areas.	Oxygen	88-94	heparin binding EGF like growth factor	Homo sapiens	29-35	
16407398-0	2006	Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.	Oxygen	34-40	heparin binding EGF like growth factor	Homo sapiens	104-142	
16407398-3	2006	Using a well-characterized human first trimester cytotrophoblast cell line, we found that a 4-hour exposure to 2% O(2) upregulates HBEGF synthesis and secretion independently of an increase in its mRNA.	Oxygen	114-118	heparin binding EGF like growth factor	Homo sapiens	131-136	
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	heparin binding EGF like growth factor	Homo sapiens	46-51	
16407398-5	2006	At 2% O(2), signaling via HER1 or HER4, known HBEGF receptors, is required for both HBEGF upregulation and protection against apoptosis.	Oxygen	6-10	heparin binding EGF like growth factor	Homo sapiens	84-89	
16407398-7	2006	The restoration of trophoblast survival by the addition of soluble HBEGF in cultures exposed to low O(2) and metalloproteinase inhibitor suggests that the effects of HBEGF are mediated by autocrine/paracrine, rather than juxtacrine, signaling.	Oxygen	100-104	heparin binding EGF like growth factor	Homo sapiens	67-72	
16407398-8	2006	Our results provide evidence that a post-transcriptional mechanism induced in trophoblasts by low O(2) rapidly amplifies HBEGF signaling to inhibit apoptosis.	Oxygen	98-102	heparin binding EGF like growth factor	Homo sapiens	121-126	
31878047-9	2019	Reactive oxygen species (ROS) appeared to play a key role in ASC stimulation as the inhibition of ROS generation and NOX4 knockout attenuated ASC stimulation and THPO upregulation by HB-EGF.	Oxygen	9-15	heparin binding EGF like growth factor	Homo sapiens	183-189	
18395045-1	2008	OBJECTIVE: The antiapoptotic action of heparin-binding epidermal growth factor (HBEGF)-like growth factor and its regulation by O(2) constitutes a key factor for trophoblast survival.	Oxygen	128-132	heparin binding EGF like growth factor	Homo sapiens	80-85	
28731464-1	2017	Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling.	Oxygen	41-47	heparin binding EGF like growth factor	Homo sapiens	130-135	
28731464-6	2017	Proximity ligation assays demonstrated interactions between HSP70 and MMP2, and between MMP2 and HBEGF, supporting the concept that MMP2-mediated shedding of HBEGF, initiated by HSP70, contributes to trophoblast survival at the low O2 concentrations encountered during the first trimester, and is essential for successful pregnancy outcomes.	Oxygen	232-234	heparin binding EGF like growth factor	Homo sapiens	158-163