PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32053662-2 2020 Sre1, the homolog of SREBP in the fission yeast Schizosaccharomyces pombe (S. pombe), regulates genes involved in the transcriptional responses to low sterol as well as low oxygen. Oxygen 173-179 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 21-26 25619842-0 2015 SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oxygen 82-88 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 0-5 24327658-2 2014 In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis. Oxygen 40-46 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 18-23 24327658-2 2014 In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis. Oxygen 98-104 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 18-23 24327658-2 2014 In fission yeast, SREBP functions in an oxygen-sensing pathway to promote adaptation to decreased oxygen supply that limits oxygen-dependent sterol synthesis. Oxygen 98-104 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 18-23 24327658-3 2014 Low oxygen stimulates proteolytic cleavage of the SREBP homolog Sre1, generating the active transcription factor Sre1N that drives expression of sterol biosynthetic enzymes. Oxygen 4-10 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 50-55 21481773-1 2011 Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Oxygen 182-188 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 57-98 21481773-1 2011 Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Oxygen 182-188 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 100-105 20959444-1 2010 In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply. Oxygen 217-223 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 149-154 19749173-1 2009 The mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adaptation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and nutritional conditions are suboptimal for fungal growth. Oxygen 171-177 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 14-55 19749173-1 2009 The mammalian sterol regulatory element-binding protein (SREBP) homolog, Sre1, is important for adaptation and growth of Cryptococcus neoformans in the mouse brain, where oxygen concentration and nutritional conditions are suboptimal for fungal growth. Oxygen 171-177 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 57-62 19749173-3 2009 We generated mutants susceptible to low oxygen and identified six genes that play a role in the SREBP pathway. Oxygen 40-46 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 96-101 19749173-9 2009 These findings suggest that the SREBP pathway is highly conserved in C. neoformans and it serves as an important link between sterol biosynthesis, oxygen sensing, CoCl(2) sensitivity, and virulence in C. neoformans. Oxygen 147-153 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 32-37 18276645-2 2008 In fission yeast, the ortholog of mammalian sterol regulatory element binding protein (SREBP), called Sre1, activates low-oxygen gene expression and is essential for anaerobic growth. Oxygen 122-128 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 44-85 18276645-2 2008 In fission yeast, the ortholog of mammalian sterol regulatory element binding protein (SREBP), called Sre1, activates low-oxygen gene expression and is essential for anaerobic growth. Oxygen 122-128 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 87-92 18276645-9 2008 Together, these results describe a new mechanism for oxygen-dependent control of gene expression and provide an example of negative regulation of protein expression by an SREBP homolog. Oxygen 53-59 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 171-176 17696611-0 2007 SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast. Oxygen 15-21 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 0-5 17696611-5 2007 Sre1, the yeast ortholog of the mammalian membrane-bound transcription factor sterol regulatory element binding protein (SREBP), directly induces the expression and mobilization of Tf2 retrotransposons under low oxygen. Oxygen 212-218 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 78-119 17696611-5 2007 Sre1, the yeast ortholog of the mammalian membrane-bound transcription factor sterol regulatory element binding protein (SREBP), directly induces the expression and mobilization of Tf2 retrotransposons under low oxygen. Oxygen 212-218 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 121-126 17462012-3 2007 We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway. Oxygen 116-122 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 49-90 17462012-3 2007 We found that SRE1, a homologue of the mammalian sterol regulatory element-binding protein (SREBP), functions in an oxygen-sensing pathway. Oxygen 116-122 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 92-97 17303406-8 2007 In addition, the SREBP pathway has been found to regulate a diverse set of cellular processes, including phagocytosis, cell cycle progression, oxygen sensing and survival in response to bacterial infection. Oxygen 143-149 CCHC-type zinc finger nucleic acid binding protein Homo sapiens 17-22