PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34502140-2 2021 In this study, we engineered a new light-oxygen-voltage-sensing (LOV) domain-based optogenetic cell line (opto-TLR4 PANC-1) that enables time-resolved activation of the NF-kappaB and extracellular-signal regulated kinases (ERK)1/2 signalling pathway upon blue light-sensitive homodimerisation of the TLR4-LOV fusion protein. Oxygen 41-47 mitogen-activated protein kinase 3 Homo sapiens 183-230 31907582-4 2020 It was found that ERK1/2 phosphorylation induced by CsA was highly reduced in the presence of the reactive oxygen species (ROS) scavenger polyethylene glycol-superoxide dismutase (PEG-SOD). Oxygen 107-113 mitogen-activated protein kinase 3 Homo sapiens 18-24 33682133-6 2021 Glucose starvation also induced the accumulation of reactive oxygen species in renal cells, which was involved in the activation of the ERK1/2 cascade and the induction of autophagy in renal cells. Oxygen 61-67 mitogen-activated protein kinase 3 Homo sapiens 136-142 31860779-6 2020 There is evidence for the involvement of reactive oxygen species (ROS) in Cd-induced ERK1/2 activation. Oxygen 50-56 mitogen-activated protein kinase 3 Homo sapiens 85-91 30962349-3 2019 We show here that HIF-2alpha is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays. Oxygen 65-67 mitogen-activated protein kinase 3 Homo sapiens 128-134 25002363-5 2014 A2B adenosine receptor stimulation decreased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and stress-activated protein kinase/Jun-amino-terminal kinase (SAPK/JNK) at all three O2 concentrations. Oxygen 206-208 mitogen-activated protein kinase 3 Homo sapiens 112-118 26760116-7 2016 IGF-1 stimulated higher phosphorylation of IGF-1Rbeta, ERK1/2, and AKT, which was maintained at steady lower levels by low oxygen tension. Oxygen 123-129 mitogen-activated protein kinase 3 Homo sapiens 55-61 24506070-6 2014 Low-oxygen tension prolonged ERK1/2 and AKT phosphorylation with a slowed phosphorylation decay even in presence of IGF-I. Oxygen 4-10 mitogen-activated protein kinase 3 Homo sapiens 29-35 24835245-5 2014 HIF-1alpha induction was in part dependent on the activation of the ERK1/2 MAPK signalling pathway, which we have previously shown is active at 5% O2. Oxygen 147-149 mitogen-activated protein kinase 3 Homo sapiens 68-74 24835245-5 2014 HIF-1alpha induction was in part dependent on the activation of the ERK1/2 MAPK signalling pathway, which we have previously shown is active at 5% O2. Oxygen 147-149 mitogen-activated protein kinase 3 Homo sapiens 75-79 24835245-8 2014 In view of these data, we conclude that HIF-1alpha can be induced and activated at physiological oxygen tensions in a MAPK-dependent manner and that, although this does not lead to pro-survival responses to stress, it determines the increased cell proliferation rates that are common under these conditions. Oxygen 97-103 mitogen-activated protein kinase 3 Homo sapiens 118-122 23281060-4 2013 OGD induced a retarded and sustained increase in extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation after restoring glucose and O(2) (reperfusion-like conditions). Oxygen 144-148 mitogen-activated protein kinase 3 Homo sapiens 92-98 22886767-0 2013 Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells. Oxygen 11-17 mitogen-activated protein kinase 3 Homo sapiens 39-43 21923556-2 2012 RESULTS: Bone marrow Sca-1(+) cells were exposed to oxygen and glucose deprivation (OGD) for up to 12 h. Erk1/2 was activated in Sca-1(+) cells under OGD which was blocked by MEK inhibitor (PD98059) and resulted in accelerated cell death. Oxygen 52-58 mitogen-activated protein kinase 3 Homo sapiens 105-111 22335456-7 2012 A convergent pathway for the regulation of multiple modalities involved in O2 sensing is the mitogen activated protein kinase (p42/44 MAPK) or (ERK1/2 extracellular signal-regulated kinases) pathway terminating in a variety of transcription factors, for example, hypoxia-inducible factor 1alpha. Oxygen 75-77 mitogen-activated protein kinase 3 Homo sapiens 144-150 20518705-7 2011 Reintroduction of oxygen generates reactive oxygen species that activate protein kinase C to increase sensitivity of adenosine A(2b) receptors allowing adenosine released from ischemic cells to bind leading to activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2. Oxygen 18-24 mitogen-activated protein kinase 3 Homo sapiens 258-299 22056361-11 2012 The combination of hyperglycemia and high oxygen levels (21%) reduces proliferation of human first-trimester trophoblasts in a ROS-independent manner involving MAPK. Oxygen 42-48 mitogen-activated protein kinase 3 Homo sapiens 160-164 15743827-7 2005 TRAF4-p47phox binding was accompanied by a progressive increase in extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38(MAPK) activation, which was inhibited by an O2- scavenger, tiron. Oxygen 175-177 mitogen-activated protein kinase 3 Homo sapiens 115-121 20497028-0 2010 Hyperbaric oxygen-stimulated proliferation and growth of osteoblasts may be mediated through the FGF-2/MEK/ERK 1/2/NF-kappaB and PKC/JNK pathways. Oxygen 11-17 mitogen-activated protein kinase 3 Homo sapiens 107-114 20497028-5 2010 Hyperbaric O2 treatment stimulated significantly increased mRNA expression of fibroblast growth factor (FGF)-2 as well as protein expression levels of Akt, p70(S6K), phosphorylated ERK, nuclear factor (NF)-kappaB, protein kinase C (PKC)alpha, and phosphorylated c-Jun N-terminal kinase (JNK). Oxygen 11-13 mitogen-activated protein kinase 3 Homo sapiens 181-184 20228054-5 2010 At these physiological oxygen levels, we found a constitutive activation of the ERK1/2 MAPK in all the models studied. Oxygen 23-29 mitogen-activated protein kinase 3 Homo sapiens 80-86 16185670-0 2005 Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2. Oxygen 60-66 mitogen-activated protein kinase 3 Homo sapiens 140-146 21510275-0 2011 Different activation of ERK1/2 and p38 with hyperbaric oxygen in dorsal root ganglion. Oxygen 55-61 mitogen-activated protein kinase 3 Homo sapiens 24-30 21510275-4 2011 Using Western blot analysis, we found that the phosphorylation levels of ERK1/2 (phospho-ERK1/2) increased significantly (p < 0.05, n = 3 for each group) in the six-hour treatment of 100% oxygen at a pressure of 2.3 ATA. Oxygen 191-197 mitogen-activated protein kinase 3 Homo sapiens 73-79 21510275-4 2011 Using Western blot analysis, we found that the phosphorylation levels of ERK1/2 (phospho-ERK1/2) increased significantly (p < 0.05, n = 3 for each group) in the six-hour treatment of 100% oxygen at a pressure of 2.3 ATA. Oxygen 191-197 mitogen-activated protein kinase 3 Homo sapiens 89-95 21510275-6 2011 These results demonstrate that the ERK1/2 and p38 have been differently activated in the DRG by prolonged hyperbaric oxygen exposure. Oxygen 117-123 mitogen-activated protein kinase 3 Homo sapiens 35-41 20037603-6 2010 CONCLUSION: Activation of beta-AR receptor transactivates epidermal growth factor receptor (EGFR) and then elicits Akt and ERK1/2 in a PKA-dependent manner, which together up-regulate levels of HIF-1alpha and downstream target genes independently of oxygen level. Oxygen 250-256 mitogen-activated protein kinase 3 Homo sapiens 123-129 19406746-6 2009 We subsequently discovered that SMG-1 kinase activity was activated by hypoxia, and depletion of SMG-1 up-regulated MAPK activity under low oxygen. Oxygen 140-146 mitogen-activated protein kinase 3 Homo sapiens 116-120 17680990-2 2007 In addition, the possible involvement of Ras/extracellular-regulated kinase (ERK) ERK1/2 pathway in preserving cortical neurons exposed to oxygen and glucose deprivation (OGD) followed by reoxygenation was also examined. Oxygen 139-145 mitogen-activated protein kinase 3 Homo sapiens 77-80 16520989-8 2006 In addition, in 20% O2, but not in 2% O2, 4-HPR obviously downregulated the protein expression of procaspase-3, ERK1/2 and XIAP, and increased the cleavage of PARP. Oxygen 20-22 mitogen-activated protein kinase 3 Homo sapiens 112-118 16103078-4 2005 We found that 24-hour hypoxia (<0.1% O2) alone (no serum deprivation) showed sustained activation of extracellular signal-regulated kinase 1/2 (ERK1/2) associated with bcl-2 up-regulation and resistance to etoposide-induced (5 mumol/L) apoptosis. Oxygen 40-42 mitogen-activated protein kinase 3 Homo sapiens 147-153 7923153-4 1994 Furthermore, although conditions of low oxygen can also activate mitogen-activated protein kinases (ERK1 and ERK2), these kinases do not appear to be involved in regulating NF-kappa B by low oxygen conditions, as dominant negative mutants of mitogen-activated protein kinase do not inhibit NF-kappa B activation by hypoxia. Oxygen 40-46 mitogen-activated protein kinase 3 Homo sapiens 100-104 15159288-7 2004 Two oxygen radical scavengers and the epidermal growth factor receptor (EGFR) antagonist AG1478 reduced Ang II-, Ald-, and combination-induced ERK1/2 phosphorylation. Oxygen 4-10 mitogen-activated protein kinase 3 Homo sapiens 143-149 12151519-8 2002 CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1). Oxygen 20-22 mitogen-activated protein kinase 3 Homo sapiens 184-223 12151519-8 2002 CGN incubated at 5% O2 for 9 hr showed increased levels of the vascular endothelial growth factor (VEGF), the VEGF receptor-2 (VEGFR-2), phosphorylated Akt/protein kinase B (PKB), and extracellular signal-regulated kinase 1 (ERK1). Oxygen 20-22 mitogen-activated protein kinase 3 Homo sapiens 225-229 15474364-5 2004 Oxygen caused oxidative stress, decreased expression of neurotrophins, and inactivation of survival signaling proteins Ras, extracellular signal-regulated kinase (ERK 1/2), and protein kinase B (Akt). Oxygen 0-6 mitogen-activated protein kinase 3 Homo sapiens 163-170 12663441-4 2003 The Ang II-dependent O2- production was suppressed by specific inhibitors of AT1 receptors, of the p38MAPK and ERK1/2 pathways, and of flavin oxidases. Oxygen 21-23 mitogen-activated protein kinase 3 Homo sapiens 111-117 10989603-0 2000 Differential activation of ERK 1/2 and JNK in normal human fibroblast-like cells in response to UVC radiation under different oxygen tensions. Oxygen 126-132 mitogen-activated protein kinase 3 Homo sapiens 27-34 10989603-8 2000 Furthermore, the balance between ERK1/2 and JNK activities after UV irradiation under different oxygen tensions possibly modified cellular outcome in response to UV. Oxygen 96-102 mitogen-activated protein kinase 3 Homo sapiens 33-39