PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31614143-0	2019	Neurotensin receptors regulate transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	82-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67	
9383735-8	1997	Temperature-induced oxidation of rhuMAb HER2 occurred by the formation of free radicals, and light-induced oxidation of rhuMAb HER2 occurred via single oxygen pathway.	Oxygen	152-158	erb-b2 receptor tyrosine kinase 2	Homo sapiens	127-131	
9383735-9	1997	Antioxidants, such as methionine, sodium thiosulfate, catalase, or platinum, prevented Met oxidation in rhuMAb HER2, presumably as free radicals or oxygen scavengers.	Oxygen	148-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-115	
33609419-10	2021	The tumor cells from MMTV-ErbB2/Leprdb/db transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.	Oxygen	136-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-31	
32596323-11	2020	Gene Ontology (GO) analysis indicated that these DEGs were significantly related to the positive regulation of epidermal growth factor-activated receptor activity, the positive regulation of the ERBB (erb-b2 receptor tyrosine kinase) signaling pathway, the differentiation of trophoblast giant cells, oxygen transport, immune-related pathways, and inflammation-related pathways.	Oxygen	301-307	erb-b2 receptor tyrosine kinase 2	Homo sapiens	201-207	
31614143-4	2019	Here the effects of reactive oxygen species on the transactivation of the EGFR and HER2 were investigated.	Oxygen	29-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87	
31614143-11	2019	The results indicate that neurotensin receptor 1 regulates the transactivation of the EGFR and HER2 in a reactive oxygen species-dependent manner.	Oxygen	114-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	95-99	
24142693-7	2013	By contrast, ligand stimulation of non-overexpressed ERBB2 transiently removes UCP2 and paradoxically reduces the mitochondrial membrane potential, oxygen consumption, and OXPHOS on a signaling time scale.	Oxygen	148-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-58	
26727049-6	2016	The in vitro analysis showed that LCC6(HER-2) cells become more hypoxic in 1% oxygen and utilise significantly more glucose in normoxia compared to LCC6(Vector)cells (p < 0.005).	Oxygen	78-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-44	
26727049-7	2016	Amalgamation of all the data points suggests a novel metabolic adaptation driven by HER-2 overexpression where higher oxygen and glucose metabolic rates produce rich energy supply but also a more hypoxic tumour mass.	Oxygen	118-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-89	
26254336-6	2015	Interestingly, although mitochondrial ROS emission is reduced in the ErbB2(tg) hearts, oxygen consumption rates and complex I activity are similar to control littermates.	Oxygen	87-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-78	
18365198-8	2009	These results indicate that Her2 blockade can improve tumor oxygenation by decreasing oxygen consumption (reducing tumor cell proliferation and inducing necrosis) and increasing oxygen delivery (vascular density and architecture).	Oxygen	60-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32	
18365198-8	2009	These results indicate that Her2 blockade can improve tumor oxygenation by decreasing oxygen consumption (reducing tumor cell proliferation and inducing necrosis) and increasing oxygen delivery (vascular density and architecture).	Oxygen	86-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-32