PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15374470-5 1990 The mechanism of this competition is, however, not a direct reaction, but it is based on the rather quick autoxidation of the dissolved ID-H generating O2(-*) radicals. Oxygen 152-154 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 136-140 20513808-2 2010 The NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) function at a crossroads of cellular metabolism in lipid synthesis, cellular defense against oxidative stress, oxidative respiration, and oxygen-sensing signal transduction. Oxygen 210-216 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 57-61 19359588-3 2009 Forced expression of mutant IDH1 in cultured cells reduces formation of the enzyme product, alpha-ketoglutarate (alpha-KG), and increases the levels of hypoxia-inducible factor subunit HIF-1alpha, a transcription factor that facilitates tumor growth when oxygen is low and whose stability is regulated by alpha-KG. Oxygen 255-261 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 28-32 15374470-7 1990 This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN). Oxygen 51-53 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 101-105 15374470-7 1990 This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN). Oxygen 51-53 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 158-162 15374470-7 1990 This statement has been proven by showing (i) that O2* radicals generated during the autoxidation of ID-H can directly be trapped on DMPO; (ii) the effect of ID-H on the OH* free radicals is abolished if SOD is added to the system; (iii) the O2(-*) radicals generated by ID-H autoxidation reduce directly the OH-spin adducts on various kinds of nitroxide type spin traps (e.g. TEMPO, TMPN). Oxygen 51-53 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 158-162 34115146-1 2022 PURPOSE: This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma. Oxygen 186-192 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 245-248 33918764-9 2021 The dynamic changes of blood perfusion, microvessel density, neovascularization activity, and oxygen metabolism showed a close physiological interplay in the one-year period prior to radiological recurrence of IDH-mutated AG. Oxygen 94-100 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 210-213 31591388-5 2019 Conversely, ectopic expression of mutant IDH1 or treatment of cells with cell-permeable D-2-HG promotes the accumulation of lipid reactive oxygen species (ROS) and subsequently ferroptosis. Oxygen 139-145 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 41-45 31676791-4 2019 However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer). Oxygen 188-194 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 63-87 31676791-4 2019 However, its main role is to consume acetyl-CoA, which unlocks isocitrate dehydrogenase (IDH)-dependent reductive carboxylation, producing the reductive power necessary to quench reactive oxygen species (ROS) originated during the switch from two-dimensional (2D) to three-dimensional (3D) growth (a necessary hallmark of cancer). Oxygen 188-194 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 89-92 31066901-0 2019 Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. Oxygen 96-102 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 36-39 31066901-2 2019 We hypothesized non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could be performed using a new pH- and oxygen-sensitive molecular MRI technique. Oxygen 143-149 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 84-88 30512923-8 2018 IDPC@Zr-PEG nanocomposites can produce oxygen in the tumor microenvironment during the course of tumor treatment, thereby alleviating the hypoxic state and improving the therapeutic effect. Oxygen 39-45 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-4 28467784-6 2017 In vitro, we observed that IDH1MUT cancer cells have a higher basal respiration compared to IDH1WT cancer cells and inhibition of the IDH1MUT shifts the metabolism by decreasing oxygen consumption and increasing glycolysis. Oxygen 178-184 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 27-31 29718366-0 2018 Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma. Oxygen 30-36 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 113-117 27982759-0 2017 MR Imaging-derived Oxygen Metabolism and Neovascularization Characterization for Grading and IDH Gene Mutation Detection of Gliomas. Oxygen 19-25 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 93-96 27982759-11 2017 Conclusion MR imaging-derived oxygen metabolism and neovascularization characterization may be useful for grading and IDH mutation detection of gliomas and requires only 7 minutes of extra imaging time. Oxygen 30-36 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 118-121