PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34188711-7 2021 Following treatment of the cells with the ERK activator, tert-Butylhydroquinone, the anti-invasive effects of melatonin were reversed by rescuing epithelial-to-mesenchymal transition in GBC cells. 2-tert-butylhydroquinone 57-79 mitogen-activated protein kinase 1 Homo sapiens 42-45 21351160-7 2011 The negative effects were partly reversed by an inhibitor of p38 which restored tBHQ mediated protection against oxidative stress. 2-tert-butylhydroquinone 80-84 mitogen-activated protein kinase 1 Homo sapiens 61-64 35567943-10 2022 The potential pathway was explored by RNA-seq and the ERK inhibitor SCH772984 and the ERK activator tBHQ were applied to verify the effect of MTHFD2 in NPC via the ERK pathway. 2-tert-butylhydroquinone 100-104 mitogen-activated protein kinase 1 Homo sapiens 86-89 35567943-10 2022 The potential pathway was explored by RNA-seq and the ERK inhibitor SCH772984 and the ERK activator tBHQ were applied to verify the effect of MTHFD2 in NPC via the ERK pathway. 2-tert-butylhydroquinone 100-104 mitogen-activated protein kinase 1 Homo sapiens 164-167 29363720-7 2018 Furthermore, TBMS1 combined with TBHQ (an ERK activator) dramatically suppressed TBMS1-induced apoptosis and stimulated TBMS1-reduced migration and invasion in NCI-H1299 cells, suggesting that TBMS1 inhibits the ERK signaling pathway and represses the growth and metastasis of NCI-H1299 cells. 2-tert-butylhydroquinone 33-37 mitogen-activated protein kinase 1 Homo sapiens 42-45 29363720-7 2018 Furthermore, TBMS1 combined with TBHQ (an ERK activator) dramatically suppressed TBMS1-induced apoptosis and stimulated TBMS1-reduced migration and invasion in NCI-H1299 cells, suggesting that TBMS1 inhibits the ERK signaling pathway and represses the growth and metastasis of NCI-H1299 cells. 2-tert-butylhydroquinone 33-37 mitogen-activated protein kinase 1 Homo sapiens 212-215 34202288-6 2021 Furthermore, the use of ERK inhibitor (U0126) and activator (tBHQ) confirmed that the pharmaceutic inhibition of MEK-ERK augmented the LCN2-mediated MET suppression and migration of U2OS and HOS cells. 2-tert-butylhydroquinone 61-65 mitogen-activated protein kinase 1 Homo sapiens 117-120 35567943-17 2022 Furthermore, the application of the selective ERK inhibitor SCH772984 and the ERK activator tBHQ confirmed that MTHFD2-knockdown inhibited the proliferation and migration of NPC cells via the ERK signaling pathway. 2-tert-butylhydroquinone 92-96 mitogen-activated protein kinase 1 Homo sapiens 78-81 35567943-17 2022 Furthermore, the application of the selective ERK inhibitor SCH772984 and the ERK activator tBHQ confirmed that MTHFD2-knockdown inhibited the proliferation and migration of NPC cells via the ERK signaling pathway. 2-tert-butylhydroquinone 92-96 mitogen-activated protein kinase 1 Homo sapiens 192-195 12671299-4 1998 Butylated hydroxyanisol (BHA) and its metabolite, t-butyl-hydroquinone (tBHQ), both are well known phenolic antioxidants used in food preservatives, strongly activated c-Jun N-terminal kinase 1 (JNK1) and/or extracellular signal-regulated protein kinase 2 (ERK2) in a dose- and time-dependent fashion. 2-tert-butylhydroquinone 50-70 mitogen-activated protein kinase 1 Homo sapiens 208-255 11768769-6 2001 BHA and tBHQ are both well-known phenolic antioxidants used as food preservatives, and strongly activate c-Jun N-terminal kinase 1 (JNK1), extracellular signal-regulated protein kinase 2 (ERK2), or p38, in a time- and dose-dependent fashion. 2-tert-butylhydroquinone 8-12 mitogen-activated protein kinase 1 Homo sapiens 139-186 11768769-6 2001 BHA and tBHQ are both well-known phenolic antioxidants used as food preservatives, and strongly activate c-Jun N-terminal kinase 1 (JNK1), extracellular signal-regulated protein kinase 2 (ERK2), or p38, in a time- and dose-dependent fashion. 2-tert-butylhydroquinone 8-12 mitogen-activated protein kinase 1 Homo sapiens 188-192 11768769-6 2001 BHA and tBHQ are both well-known phenolic antioxidants used as food preservatives, and strongly activate c-Jun N-terminal kinase 1 (JNK1), extracellular signal-regulated protein kinase 2 (ERK2), or p38, in a time- and dose-dependent fashion. 2-tert-butylhydroquinone 8-12 mitogen-activated protein kinase 1 Homo sapiens 198-201 11768769-11 2001 A model is proposed where these xenobiotics (BHA, tBHQ, GTP, EGCG, PEITC, sulforaphane) activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival. 2-tert-butylhydroquinone 50-54 mitogen-activated protein kinase 1 Homo sapiens 101-105 10488090-4 1999 tBHQ and SUL also activated MAPK kinase. 2-tert-butylhydroquinone 0-4 mitogen-activated protein kinase 1 Homo sapiens 28-32 10488090-5 1999 Inhibition of MAPK kinase with its inhibitor, PD98059, abolished ERK2 activation and impaired the induction of quinone reductase, a phase II detoxifying enzyme, and antioxidant response element (ARE)-linked reporter gene by tBHQ and SUL. 2-tert-butylhydroquinone 224-228 mitogen-activated protein kinase 1 Homo sapiens 14-18 10488090-6 1999 Overexpression of a dominant-negative mutant of ERK2 also attenuated tBHQ and SUL induction of ARE reporter gene activity. 2-tert-butylhydroquinone 69-73 mitogen-activated protein kinase 1 Homo sapiens 48-52 12671299-4 1998 Butylated hydroxyanisol (BHA) and its metabolite, t-butyl-hydroquinone (tBHQ), both are well known phenolic antioxidants used in food preservatives, strongly activated c-Jun N-terminal kinase 1 (JNK1) and/or extracellular signal-regulated protein kinase 2 (ERK2) in a dose- and time-dependent fashion. 2-tert-butylhydroquinone 50-70 mitogen-activated protein kinase 1 Homo sapiens 257-261 12671299-4 1998 Butylated hydroxyanisol (BHA) and its metabolite, t-butyl-hydroquinone (tBHQ), both are well known phenolic antioxidants used in food preservatives, strongly activated c-Jun N-terminal kinase 1 (JNK1) and/or extracellular signal-regulated protein kinase 2 (ERK2) in a dose- and time-dependent fashion. 2-tert-butylhydroquinone 72-76 mitogen-activated protein kinase 1 Homo sapiens 208-255 12671299-4 1998 Butylated hydroxyanisol (BHA) and its metabolite, t-butyl-hydroquinone (tBHQ), both are well known phenolic antioxidants used in food preservatives, strongly activated c-Jun N-terminal kinase 1 (JNK1) and/or extracellular signal-regulated protein kinase 2 (ERK2) in a dose- and time-dependent fashion. 2-tert-butylhydroquinone 72-76 mitogen-activated protein kinase 1 Homo sapiens 257-261 9360968-10 1997 Modulation of intracellular H2O2 levels by direct addition of catalase or pretreatment with a catalase inhibitor, aminotriazole, also affected BHA- and tBHQ-stimulated ERK2 activity but not JNK1, indicating the involvement of oxidative stress in the ERK2 activation by these two compounds. 2-tert-butylhydroquinone 152-156 mitogen-activated protein kinase 1 Homo sapiens 168-172 9360968-10 1997 Modulation of intracellular H2O2 levels by direct addition of catalase or pretreatment with a catalase inhibitor, aminotriazole, also affected BHA- and tBHQ-stimulated ERK2 activity but not JNK1, indicating the involvement of oxidative stress in the ERK2 activation by these two compounds. 2-tert-butylhydroquinone 152-156 mitogen-activated protein kinase 1 Homo sapiens 250-254 9360968-6 1997 A major metabolite of BHA, tert-butylhydroquinone (tBHQ), also activated ERK2 but weakly stimulated JNK1 activity. 2-tert-butylhydroquinone 27-49 mitogen-activated protein kinase 1 Homo sapiens 73-77 9360968-6 1997 A major metabolite of BHA, tert-butylhydroquinone (tBHQ), also activated ERK2 but weakly stimulated JNK1 activity. 2-tert-butylhydroquinone 51-55 mitogen-activated protein kinase 1 Homo sapiens 73-77 9360968-7 1997 Furthermore, tBHQ activation of ERK2 was late and prolonged, showing a kinetics different from that induced by BHA. 2-tert-butylhydroquinone 13-17 mitogen-activated protein kinase 1 Homo sapiens 32-36 9360968-13 1997 Furthermore, BHA and tBHQ activation of ERK2 was strongly inhibited by ascorbic acid and a peroxidase inhibitor, sodium azide, suggesting the potential role of phenoxyl radicals and/or their derivatives. 2-tert-butylhydroquinone 21-25 mitogen-activated protein kinase 1 Homo sapiens 40-44 9360968-14 1997 Taken together, our results indicate that (i) BHA and its metabolite tBHQ differentially regulate MAPK pathways, and (ii) oxidative stress due to the generation of reactive intermediates, possibly phenoxyl radicals but not H2O2, is responsible for the ERK2 activation by BHA and tBHQ, whereas the JNK1 activation may require a distinct yet unknown mechanism. 2-tert-butylhydroquinone 69-73 mitogen-activated protein kinase 1 Homo sapiens 98-102 9360968-14 1997 Taken together, our results indicate that (i) BHA and its metabolite tBHQ differentially regulate MAPK pathways, and (ii) oxidative stress due to the generation of reactive intermediates, possibly phenoxyl radicals but not H2O2, is responsible for the ERK2 activation by BHA and tBHQ, whereas the JNK1 activation may require a distinct yet unknown mechanism. 2-tert-butylhydroquinone 69-73 mitogen-activated protein kinase 1 Homo sapiens 252-256 34733776-8 2021 Meanwhile ERK activator(tBHQ) significantly reversed the irradiation-induced suppression of proliferation, migration and invasion in T24 and EJ cell lines. 2-tert-butylhydroquinone 24-28 mitogen-activated protein kinase 1 Homo sapiens 10-13